Published January 1, 2013
| Version v1
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Evaluation of serum neopterin levels and its relationship with adipokines in pediatric obesity-related nonalcoholic fatty liver disease and healthy adolescents
Creators
- 1. Dokuz Eylul Univ, Fac Med, Dept Pediat, Div Pediat Gastroenterol Hepatol & Nutr, Izmir, Turkey
- 2. Dokuz Eylul Univ, Fac Med, Div Pediat Gastroenterol Hepatol & Nutr, Izmir, Turkey
- 3. Dokuz Eylul Univ, Fac Med, Dept Med Biochem, Izmir, Turkey
- 4. Dokuz Eylul Univ, Fac Med, Res Lab, Izmir, Turkey
Description
Aim: Nonalcoholic fatty liver disease (NAFLD) is associated with inflammation and increased risk of atherosclerosis. Neopterin is regarded as a biochemical marker of cell-mediated immunity, which is secreted by monocytes and macrophages, mainly in response to interferon-gamma. The aim of the present study was to investigate the serum neopterin levels in obese adolescents and compare the neopterin levels in patients with and without NAFLD and also with healthy controls. The second aim of the study was to research the possible relationship between neopterin levels and adipokines (leptin, adiponectin, resistin, and ghrelin).
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