Published January 1, 2013
| Version v1
Journal article
Open
CYTOGENETIC DAMAGE IN TURKISH COKE OVEN WORKERS EXPOSE l TO POLYCYCLIC AROMATIC HYDROCARBONS: ASSOCIATION WITH CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, AND GSTP1 GENE POLYMORPHISMS
Creators
- 1. Ankara Univ, Fac Pharm, Dept Toxicol, Tandogan, Turkey
- 2. Gazi Univ, Dept Toxicol, Fac Pharm, Etiler, Turkey
- 3. Yuksek Ihtisas Hosp, Gastrointestinal Surg Dept, Sihhiye, Turkey
- 4. Eregli Iron & Steel Works Co, Karadeniz Eregli, Turkey
Description
The aim of this study was to determine the frequencies of chromosomal aberrations (CA) and cytochalasin-blocked micronuclei (CBMN) in peripheral blood lymphocytes from Turkish coke oven workers and the influence of CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 gene polymorphisms on these biomarkers. Cytogenetic analysis showed that occupational exposure significantly increased the CA and CBMN frequencies. Gene polymorphisms, on the other hand, did not affect CA or CBMN in either exposed or control subjects. However, due to the limited sample size, our findings need to be verified in future studies with a larger sample.
Files
bib-bf85fbb6-f457-411d-8ddd-e81ca8936096.txt
Files
(395 Bytes)
| Name | Size | Download all |
|---|---|---|
|
md5:42e72c4ddde1355ac46a86a5e2ee8f15
|
395 Bytes | Preview Download |