Published January 1, 2020 | Version v1
Journal article Open

Antenatal pentoxifylline therapy to prevent endotoxin-induced fetal injury in the preterm goat model

  • 1. Suleyman Demirel Univ, Dept Obstet & Gynecol, Fac Med, Isparta, Turkey
  • 2. Burdur Mehmet Akif Ersoy Univ, Dept Obstet & Gynecol, Fac Vet Med, Burdur, Turkey
  • 3. Burdur Mehmet Akif Ersoy Univ, Dept Pathol, Fac Vet Med, Burdur, Turkey
  • 4. Cukurova Univ, Dept Pathol, Fac Ceyhan Vet Med, Adana, Turkey
  • 5. Isparta Univ Appl Sci, Dept Anim Sci, Fac Agr, Isparta, Turkey
  • 6. Kutahya Hlth Sci Univ, Dept Histol & Embryol, Fac Med, Kutahya, Turkey

Description

Objective: Pentoxifylline (PTX) has immunomodulatory properties and is known to reduce sepsis-associated infant mortality. We aimed to evaluate maternal oral and intra-amniotic administration of PTX for the prevention of fetal inflammation and injury in a caprine model.

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