Yayınlanmış 1 Ocak 2020 | Sürüm v1
Dergi makalesi Açık

GDNF/RET signaling in dopamine neurons in vivo

  • 1. Univ Plymouth, Inst Translat & Stratified Med, Peninsula Med Sch, Fac Hlth, Plymouth, Devon, England
  • 2. Univ Plymouth, Fac Arts, Plymouth, Devon, England

Açıklama

The glial cell line-derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal both in tandem and separately to exert many vital functions in the midbrain dopamine system. It is known that Ret has effects on maintenance, physiology, protection and regeneration in the midbrain dopamine system, with the physiological functions of GDNF still somewhat unclear. Notwithstanding, Ret ligands, such as GDNF, are considered as promising candidates for neuroprotection and/or regeneration in Parkinson's disease, although data from clinical trials are so far inconclusive. In this review, we discuss the current knowledge of GDNF/Ret signaling in the dopamine system in vivo as well as crosstalk with pathology-associated proteins and their signaling in mammals.

Dosyalar

bib-3457f2a9-5f59-4a9f-a3f1-110dc1d1fb39.txt

Dosyalar (143 Bytes)

Ad Boyut Hepisini indir
md5:e26aea20a1742840abe3e4aee751d6ad
143 Bytes Ön İzleme İndir