Published January 1, 2020
| Version v1
Journal article
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Optimization of 5-aminolevulinic acid-based photodynamic therapy protocol for breast cancer cells
Creators
- 1. Sakarya Univ, Fac Med, Dept Med Biol, Sakarya, Turkey
- 2. Sakarya Univ, Inst Hlth Sci, Dept Med Biochem, Sakarya, Turkey
- 3. Sakarya Univ Appl Sci, Technol Fac, Dept Elect & Elect Engn, Sakarya, Turkey
- 4. Sakarya Univ, Inst Nat Sci, Dept Biomed Engn, Sakarya, Turkey
Description
Background: Photodynamic therapy (PDT) is a therapeutic strategy for the treatment of cancer. 5-aminolevulinic acid (5-ALA) as a precursor of the protoporphyrin IX (PpIX) has a great potential for PDT application. Although 5-ALA-based PDT has been studied in many pre-clinical and clinical studies for breast cancer, there are different PDT application protocols in the literature. Therefore, the aim of this study was to determine the optimal in vitro protocol for 5-ALA-based PDT in breast cancer treatment.
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