Published January 1, 2015
| Version v1
Journal article
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Trimethine cyanine dyes as fluorescent probes for amyloid fibrils: The effect of N,N '-substituents
Creators
- 1. Natl Acad Sci Ukraine, Inst Mol Biol & Genet, UA-03143 Kiev, Ukraine
- 2. Natl Acad Sci Ukraine, Inst Organ Chem, UA-02094 Kiev, Ukraine
Description
The effect of various N,N'-substituents in the molecule of benzothiazole trimethine cyanine dye on its ability to sense the amyloid aggregates of protein was studied. The dyes are low fluorescent when free and in the presence of monomeric proteins, but their emission intensity sharply increases in complexes with aggregated insulin and lysozyme, with the fluorescence quantum yield reaching up to 0.42.
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