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Published January 1, 2019 | Version v1
Journal article Open

Determining the insulin secretion potential for certain specific G-protein coupled receptors in MIN6 pancreatic beta cells

Creators

  • 1. Firat Univ, Fac Sci, Dept Biol, Mol Biol & Genet Program, Elazig, Turkey
  • 2. Firat Univ, Fac Vet Med, Dept Anim Nutr & Nutr Disorders, Elazig, Turkey
  • 3. Kings Coll London, Div Diabet & Nutr Sci, Diabet Res Grp, London, England

Description

Background/aim: The polypeptide hormone insulin is essential for the maintenance of whole-body fuel homeostasis, and defects in insulin secretion and/or action are associated with the development of type 1 and type 2 diabetes. The aim of this study was to assess the role of some G-protein coupled receptors (GPCRs), GPR54, GPR56, and GPR75, and cannabinoid receptors CB1R and CB2R, in the regulation of pancreatic beta-cell function.

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