Yayınlanmış 1 Ocak 2019 | Sürüm v1
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Natural diterpenoid alysine A isolated from Teucrium alyssifolium exerts antidiabetic effect via enhanced glucose uptake and suppressed glucose absorption

  • 1. Pamukkale Univ, Fac Arts & Sci, Dept Biol, Denizli, Turkey
  • 2. Bezmialem Vakif Univ, Fac Pharm, Dept Pharmacognosy & Phytochem, Istanbul, Turkey

Açıklama

Teucrium species have been used in folk medicine as antidiabetic, antiinflammatory, antiulcer, and antibacterial agents. We have explored in vitro antidiabetic impacts of 2 natural diterpenoids, alysine A and alysine B, isolated from Teucrium alyssifolium. The lactate dehydrogenase (LDH) cytotoxicity assay, glucose uptake test, glucose utilization (glycogen content) test, glucose transport test, glucose absorption (a-glucosidase activity) test, insulin secretion test, RNA isolation and cDNA synthesis assay, qPCR quantification assays, and statistical analyses were carried out in the present study. Alysine A exerted the following effects at non-cytotoxic doses:

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