Published January 1, 2020
| Version v1
Journal article
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Therapeutic Potentials of Inhibition of Jumonji C Domain - containing Demethylases in Acute Myeloid Leukemia
Creators
- 1. Izmir Inst Technol, Dept Mol Biol & Genet, Izmir, Turkey
- 2. Anadolu Univ, Dept Pharmacol, Fac Pharm, Eskisehir, Turkey
- 3. Sakarya Univ, Dept Hematol, Fac Med, Sakarya, Turkey
Description
Objective: Acute myeloid leukemia (AML) is a complex disease affected by both genetic and epigenetic factors. Histone methylation and demethylation are types of epigenetic modification in chromatin remodeling and gene expression. Abnormal expression of histone demethylases is indicated in many types of cancer including AML Although many commercial drugs are available to treat AML, an absolute cure has not been discovered yet. However, inhibition of demethylases could be a potential cure for AML Methylstat is a chemical agent that inhibits the Jumonji C domain-containing demethylases.
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