Published January 1, 2017
| Version v1
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Differentially regulated ADAMTS1, 8, 9, and 18 in pancreas adenocarcinoma
Creators
- 1. Ankara Numune Training & Res Hosp, Dept Gen Surg, TR-06100 Ankara, Turkey
- 2. Turgut Ozal Univ, Dept Med Genet, Fac Med, Ankara, Turkey
- 3. Turgut Ozal Univ, Dept Gen Surg, Fac Med, Ankara, Turkey
- 4. Ataturk Univ, Dept Histol & Embryol, Fac Vet Med, Erzurum, Turkey
- 5. Turgut Ozal Univ, Dept Med Pathol, Fac Med, Ankara, Turkey
- 6. Haccettepe Univ, Dept Stat, Ankara, Turkey
- 7. Turgut Ozal Univ, Dept Med Biol, Fac Med, Ankara, Turkey
Description
Introduction: Despite recent diagnostic and therapeutic improvements, pancreas cancer remains one of the highly lethal cancers. The extracellular matrix (ECM) is a physiological barrier that limits the spread of cancer cells into surrounding tissues and distant organs. Disintegrin and metalloprotease with thrombospondin motifs (ADAMTS) is a family of 19 proteases, which is involved in various biological processes such as ECM remodelling and anti-angiogenesis.
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