The first synthesis of phenylpropanoid derivative bromophenols including natural products: Formation of an indene derivative compound

Synthesis of the natural bromophenols 3,4-dibromo-5-(butoxymethyl)benzene-1,2-diol, (E)-3-(2,3-dibromo-4,5-dihydroxyphenyl)-2-methylacrylaldehyde (7), 3,4-dibromo-5-(3-hydroxy-2-methylpropyl) benzene-1,2-diol and 3-(2,3-dibromo-4,5-dihydroxyphenyl)-2-phenylpropanoic acid is reported for the first time. An indene-derived compound (12) was formed during attempts to synthesize the bromophenol 7. The formation of compound 12 is discussed. (C) 2020 Published by Elsevier Ltd.