Yayınlanmış 1 Ocak 2018 | Sürüm v1
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A New Protocol for Collagen-Induced Local Arthritis Model in Balb/c Mice

  • 1. Uludag Univ, Dept Physiol, Fac Vet Med, Bursa, Turkey
  • 2. Uludag Univ, Dept Immunol, Fac Med, Bursa, Turkey
  • 3. Uludag Univ, Dept Pathol, Fac Vet Med, Bursa, Turkey

Açıklama

Introduction: Numerous models have been described to study the pathogenesis of rheumatoid arthritis, and to develop new therapies; but each of these models has their own limitations. Nowadays, the collagen-induced arthritis (CIA) mouse model is the most commonly used model for rheumatoid arthritis studies in certain mouse strain like DBA/1 mouse. This study aimed to describe a new protocol for local induction of arthritis in Balb/c mice, including the monitoring of clinical arthritis and the protocols for histological examination of paws of mice.

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