Published January 1, 2018
| Version v1
Journal article
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Cytotoxicity of seputhecarpan D, thonningiol and 12 other phytochemicals from African flora towards human carcinoma cells
Creators
- 1. Univ Yaounde I, Dept Organ Chem, Fac Sci, Yaounde, Cameroon
- 2. Univ Botswana, Dept Chem, Fac Sci, Block 237,Private Bag 0022, Gaborone, Botswana
- 3. Univ Botswana, Dept Biol Sci, Fac Sci, Block 235,Private Bag 0022, Gaborone, Botswana
- 4. Anadolu Univ, Sci Fac, Dept Biol, Eskisehir, Turkey
Description
Background: Despite the remarkable progress in cancer therapy in recent years, this disease still remains a serious public health concern. The use of natural products has been and continues to be one of the most effective ways to fight malignancies. The cytotoxicity of 14 compounds from African medicinal plants was evaluated in four human carcinoma cell lines and normal fibroblasts. The tested samples included: beta-spinasterol (1), friedelanone (2), 16 beta-hydroxylupeol (3), beta-amyrin acetate (4), lupeol acetate (5), sequoyitol (6), rhamnitrin (7), europetin 3-O-rhamnoside (8), thonningiol (9), glyasperin F (10), seputhecarpan B (11), seputhecarpan C (12), seputhecarpan D (13) and rheediaxanthone A (14).
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