Published January 1, 2020
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Synthesis, characterization and antitumor properties of novel silver(I) and gold(I) N-heterocyclic carbene complexes
Creators
- 1. Inonu Univ, Fac Sci & Arts, Dept Chem, TR-44280 Malatya, Turkey
- 2. Inonu Univ, Fac Med, Dept Pharmaceut Microbiol, TR-44280 Malatya, Turkey
- 3. Inonu Univ, Catalysis Res & Applicat Ctr, TR-44280 Malatya, Turkey
- 4. Inonu Univ, Fac Pharm, Dept Pharmaceut Chem, TR-44280 Malatya, Turkey
- 5. Inonu Univ, Fac Med, Dept Biostat & Med Informat, TR-44280 Malatya, Turkey
- 6. Ordu Univ, Fac Sci & Arts, Dept Chem, TR-52200 Ordu, Turkey
- 7. Univ Carthage, Higher Inst Environm Sci & Technol, Res Lab Environm Sci & Technol LR16ES09, Hammam Lif, Tunisia
- 8. King Saud Univ, Coll Sci, Zool Dept, POB 2455, Riyadh 11451, Saudi Arabia
Description
In this study, two novel benzimidazolium salts consisting propane sulfonate order were integrated in high yields as N-heterocyclic carbene (NHC) precursors. The silver-NHC buildings were set up by responding 1-(2,2-dimethoxyahyl)-3-(propyl-3-sulfonate)benzimidazolium and 1-(2,2-diethoxyahyl)-3-(propyl-3-sulfonate)benzimidazolium with silver oxide on average state. Gold-NHC edifices were acquired by means of transmetallation of their silver precursors with [AuCl{S(CH3)(2)}]. The structures of all mixes were completely portrayed by spectroscopic techniques H-1 NMR, C-13{1H} NMR, IR and elemental and further analyzed by DFT/TDDFT strategies. IC50 values and cytotoxic impacts of these four complexes were controlled by the MTS put together examine with respect to three human cancer cell lines neuroblastoma (SHSY5Y), adenocarcinoma (HEP3B), and human fibroblasts (HF).
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