A NEW GERMACRANOLIDE FROM TANACETUM-DENSUM SSP SIVASICUM (COMPOSITAE)

Members of the Tanacetum genus are important medicinal plants found throughout the world which have been used in traditional medicines throughout the world.(1) In Turkey, 44 different species of Tanacetum are known, at least 15 of which are endemic.(2) One such endemic species, T. densum, is further classified into four subspecies: subsp. sivasicum, subsp, laxum, subsp, amani, and subsp. eginense. As with other members of the Compositae family, T. densum has been shown to produce a variety of sesquiterpenes, and investigations into subsp. sivasicum have previously yielded eudesmanolides, germacranolides, guaianolides, and farnesol derivatives.(3,4) In this paper we report a new germacranolide 1 from T. densum subsp. sivasicum