Comparison of pulse and super pulse radiation modes' singlet oxygen production effect in antimicrobial photodynamic therapy (AmPDT)

Photodynamic Therapy (PDT) is a treatment method in which a target region is irradiated with a light source of an appropriate wavelength to activate an introduced photosensitizer to ideally ablate the target by creation of highly toxic singlet oxygen. Due to the increment of antibiotic resistant bacteria, PDT has also become a salient method for infection treatments. The amount and the location of singlet oxygen gives information about the effectiveness of PDT. The quantitative evolution of singlet oxygen is a gold standard for the real time monitoring of the treatment efficiency during PDT.