Dergi makalesi Açık Erişim

NF-kappa B-Induced Upregulation of miR-548as-3p Increases Invasion of NSCLC by Targeting PTEN

2019    Akgun, Sakir; Kucuksayan, Hakan; Ozes, Osman N.; Can, Ozge; Alikanoglu, Arsenal S.; Yildiz, Mustafa; Akca, Hakan

Background: Non-Small Cell Lung Cancer (NSCLC) is an aggressive cancer type due to high metastatic capacity. Nuclear Factor Kappa B (NF-kappa B) is a consistently active transcription factor in malignant lung cancer cells and has crucial significance in NSCLC progression. It is also implicated in the transcriptional regulation of many genes including microRNAs (miRNAs) that function as tumor suppressor or oncogene. It has been increasingly reported that several miRNAs defined as gene members are induced by NF-kappa B. The present study aimed to find novel miRNAs that are regulated by NF-kappa B.