Dergi makalesi Açık Erişim

Rho-kinase is a negative regulator of red blood cell eNOS under basal conditions

2019    Ulker, Pinar; Ozen, Nur; Abduleyeva, Gunel; Koksoy, Sadi; Yaras, Nazmi; Basrali, Filiz

BACKGROUND: Rho-kinase, an effector of the small GTPase RhoA, is known to be a novel inhibitory regulator of eNOS in endothelial cells under basal conditions and disease states. However, although RBC possesses active RhoA/Rho-kinase pathway, Rho-kinase mediated eNOS regulation has not been investigated in RBC, so far.