Yayınlanmış 1 Ocak 2019
| Sürüm v1
Dergi makalesi
Açık
Zero-field nuclear magnetic resonance of chemically exchanging systems
Oluşturanlar
- 1. Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94158 USA
- 2. Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA
- 3. Univ Kiel, Univ Med Ctr Schleswig Holstein UKSH, Dept Radiol & Neuroradiol, Sect Biomed Imaging,Mol Imaging North Competence, Am Botan Garten 14, D-24118 Kiel, Germany
- 4. Johannes Gutenberg Univ Mainz, Helmholtz Inst Mainz, D-55099 Mainz, Germany
Açıklama
Zero- to ultralow-field (ZULF) nuclear magnetic resonance (NMR) is an emerging tool for precision chemical analysis. In this work, we study dynamic processes and investigate the influence of chemical exchange on ZULF NMR J-spectra. We develop a computational approach that allows quantitative calculation of J-spectra in the presence of chemical exchange and apply it to study aqueous solutions of [N-15]ammonium ((NH4+)-N-15) as a model system. We show that pH-dependent chemical exchange substantially affects the J-spectra and, in some cases, can lead to degradation and complete disappearance of the spectral features. To demonstrate potential applications of ZULF NMR for chemistry and biomedicine, we show a ZULF NMR spectrum of [2-C-13]pyruvic acid hyperpolarized via dissolution dynamic nuclear polarization (dDNP). We foresee applications of affordable and scalable ZULF NMR coupled with hyperpolarization to study chemical exchange phenomena in vivo and in situations where high-field NMR detection is not possible to implement.
Dosyalar
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Dosyalar
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