Dergi makalesi Açık Erişim

The altered expression of perineuronal net elements during neural differentiation

2018    Eskici, Nazli F.; Erdem-Ozdamar, Sevim; Dayangac-Erden, Didem

Background: Perineuronal nets (PNNs), which are localized around neurons during development, are specialized forms of neural extracellular matrix with neuroprotective and plasticity-regulating roles. Hyaluronan and proteoglycan link protein 1 (HAPLN1), tenascin-R (TNR) and aggrecan (ACAN) are key elements of PNNs. In diseases characterized by neuritogenesis defects, the expression of these proteins is known to be downregulated, suggesting that PNNs may have a role in neural differentiation.