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Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

2018    Cardoso, Ana Luisa; Fernandes, Adelaide; Aguilar-Pimentel, Juan Antonio; de Angelis, Martin Hrabe; Guedes, Joana Ribeiro; Brito, Maria Alexandra; Ortolano, Saida; Pani, Giovambattista; Athanasopoulou, Sophia; Gonos, Efstathios S.; Schosserer, Markus; Grillari, Johannes; Peterson, Part; Tuna, Bilge Guvenc; Dogan, Soner; Meyer, Angelika; van Os, Ronald; Trendelenburg, Anne-Ulrike

Objective: Use of the frailty index to measure an accumulation of deficits has been proven a valuable method for identifying elderly people at risk for increased vulnerability, disease, injury, and mortality. However, complementary molecular frailty biomarkers or ideally biomarker panels have not yet been identified. We conducted a systematic search to identify biomarker candidates for a frailty biomarker panel.