TUBITAK Destekli Projelerden Çıkan Yayınlar Topluluğu
Yayınlanmış 1 Ocak 2018 | Sürüm v1
Dergi makalesi Açık

Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

Oluşturanlar

  • 1. Univ Coimbra, Fac Med, Ctr Neurosci, Cell Biol, Polo 1, Coimbra, Portugal
  • 2. Univ Lisbon, Fac Pharm, Dept Biochem & Human Biol, iMed ULisboa,Res Inst Med, Lisbon, Portugal
  • 3. German Res Ctr Environm Hlth, Helmholtz Zentrum Muenchen, Inst Expt Genet, German Mouse Clin, Neuherberg, Germany
  • 4. Galicia Sur Hlth Res Inst SERGAS UVIGO, Rare Dis & Pediat Med Res Grp, Vigo, Spain
  • 5. Univ Cattolica Sacro Cuore, Inst Gen Pathol, Fac Med, Rome, Italy
  • 6. Natl Hellen Res Fdn, Inst Biol Med Chem & Biotechnol, Mol & Cellular Aging Lab, Athens, Greece
  • 7. Natl Hellen Res Fdn, Inst Biol Med Chem & Biotechnol, Athens, Greece
  • 8. Univ Nat Resources & Life Sci, Dept Biotechnol, Vienna, Austria
  • 9. Univ Nat Resources & Life Sci, Dept Biotechnol, Christian Doppler Lab Biotechnol Skin Aging, Vienna, Austria
  • 10. Univ Tartu, Inst Biomed & Translat Med, Tartu, Estonia
  • 11. Yeditepe Univ, Sch Med, Istanbul, Turkey
  • 12. Yeditepe Univ, Sch Med, Dept Med Biol, Istanbul, Turkey
  • 13. Novartis Inst Biomed Res, Musculoskeletal Dis Area, Muscle Res, Basel, Switzerland
  • 14. Univ Groningen, Univ Med Ctr Groningen, Mouse Clin Canc & Aging, Cent Anim Facil, Groningen, Netherlands
  • 15. Novartis Inst Biomed Res, Musculoskeletal Dis Area, Muscle Res, Cambridge, MA 02139 USA

Açıklama

Objective: Use of the frailty index to measure an accumulation of deficits has been proven a valuable method for identifying elderly people at risk for increased vulnerability, disease, injury, and mortality. However, complementary molecular frailty biomarkers or ideally biomarker panels have not yet been identified. We conducted a systematic search to identify biomarker candidates for a frailty biomarker panel.

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