Dergi makalesi Açık Erişim

Gemcitabine hydrochloride microspheres used for intravesical treatment of superficial bladder cancer: a comprehensive in vitro/ex vivo/in vivo evaluation

2018    Karavana, Sinem Yaprak; Senyigit, Zeynep Ay; Caliskan, Cagri; Sevin, Gulnur; Ozdemir, Derya Ilem; Erzurumlu, Yalcin; Sen, Sait; Baloglu, Esra

Introduction: Bladder cancer is responsible for more than 130,000 deaths annually worldwide. Intravesical delivery of chemotherapeutic agents provides effective drug localization to the target area to reduce toxicity and increase efficacy. This study aimed to develop ail intravesical delivery system of gemcitabine HC1 (Gem-HCl) to provide a sustained-release profile, to prolong residence time, and to enhance its efficiency in the treatment of bladder cancer.