The new dispirobino and dispiroansa spermine derivatives of cyclotriphosphazenes

In this study, the crystal structures of the dispiroansa spermine derivatives of cyclotriphosphazene are characterised for the first time. The reaction of spiro-, gem-disubstituted cyclotriphosphazene derivatives, N3P3Cl4R2 [R = NHPh, (HN(CH2)(3)NH)(0.5), (OCH2C(CH3)(2)CH2O)(0.5)], (1-3), with spermine (4), in aprotic solvents such as CH2Cl2 results in a series of dispirobino spermine derivatives of cyclotriphosphazene (5a, 6a, 7), namely spermine bridged compounds. Whereas, in protic solvents such as CHCl3 give, dispiroansa derivatives (8-10) namely tetracyclic cyclotriphosphazene. The new series of dispirobino and dispiroansa spermine derivatives of cyclotriphosphazene (5a, 6a, 7-10) have been characterised by elemental analysis, mass spectrometry, X-ray (for 5a, 8,10) and H-1, P-31 NMR spectroscopies. (C) 2009 Elsevier Ltd. All rights reserved.