Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Metformin Release
Oluşturanlar
- Sharma, Manoj B.
- Kap, Ozlem1
- Abdelmohsen, Hend A. M.
- Ashton, Mark D.2
- Harper, Garry R.2
- Firlak, Melike
- Aaltonen, Jasmine E.2
- Bolland, Kerry A.2
- Bragg, Ryan2
- Deeley, Sarah2
- Francis, Ella2
- Kazi, Nahin2
- Mapley, Bethany L.2
- Oikonomou, Vasileios2
- Aljohani, Amal D.
- Cheneler, David
- Kilic, Volkan3
- Horzum, Nesrin1
- Hardy, John G.
- 1. Izmir Katip Celebi Univ, Dept Engn Sci, TR-35620 Izmir, Turkiye
- 2. Univ Lancaster, Dept Chem, Lancaster LA1 4YB, England
- 3. Izmir Katip Celebi Univ, Dept Elect & Elect Engn, TR-35620 Izmir, Turkiye
Açıklama
The release of metformin, a drug used in the treatment of cancer and diabetes, from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle patches is demonstrated in vitro. Tuning the composition of the pHEMA hydrogels enables preparation of robust microneedle patches with mechanical properties such that they would penetrate skin (insertion force of a single microneedle to be & AP;40 N). Swelling experiments conducted at 20, 35, and 60 & DEG;C show temperature-dependent degrees of swelling and diffusion kinetics. Drug release from the pHEMA hydrogel-based microneedles is fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application for transdermal delivery of metformin for the treatment of aging, cancer, diabetes, etc.
Dosyalar
bib-999b176d-9d2e-4816-b756-7fcfdbce1137.txt
Dosyalar
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