Yayınlanmış 1 Ocak 2010
| Sürüm v1
Dergi makalesi
Açık
The Ability to Generate Senescent Progeny as a Mechanism Underlying Breast Cancer Cell Heterogeneity
Oluşturanlar
- 1. Bilkent Univ, BilGen Genet & Biotechnol Ctr, Dept Mol Biol & Genet, Ankara, Turkey
- 2. Ankara Numune Res & Teaching Hosp, Dept Surg, Ankara, Turkey
Açıklama
Background: Breast cancer is a remarkably heterogeneous disease. Luminal, basal-like, "normal-like", and ERBB2+ subgroups were identified and were shown to have different prognoses. The mechanisms underlying this heterogeneity are poorly understood. In our study, we explored the role of cellular differentiation and senescence as a potential cause of heterogeneity.
Dosyalar
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Dosyalar
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