Dergi makalesi Açık Erişim
Yi, Xue; Sarkar, Aloke; Kismali, Gorkem; Aslan, Burcu; Ayres, Mary; Iles, LaKesla R.; Keating, Michael J.; Wierda, William G.; Long, James P.; Bertilaccio, Maria Teresa Sabrina; Gandhi, Varsha
Purpose: Survival of CLL cells due to the presence of Bcl-2 and Mcl-1 has been established. Direct inhibition of Bcl-2 by venetoclax and indirect targeting of Mcl-1 with transcription inhibitors have been successful approaches for CLL. AMG-176 is a selective and direct antagonist of Mcl-1, which has shown efficacy in several hematologic malignancies; however, its effect on CLL is elusive. We evaluated biological and molecular effects of AMG-176 in primary CLL cells.
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