Published January 1, 2012
| Version v1
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Potent Antioxidant and Lipoxygenase Inhibitory Flavanone and Chalcone from Erythrina mildbraedii Harms (Fabaceae) of Cameroon
Creators
- 1. Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci ICCBS, Karachi 75270, Pakistan
- 2. Pharmaceut & Res Ctr, Pakistan Council Sci & Ind Res Labs Complex, Karachi, Pakistan
Description
In continuation of our search for new secondary metabolites from African Erythrina species, E. mildbraedii of Cameroon was investigated. As a result of this study, a new flavanone (mildbone, 1) and a new chalcone (mildbenone, 2) have been obtained and characterized by spectroscopic means. Both the compounds exhibited significant antioxidant and moderate lipoxygenase inhibitory activities. Compounds 1 and 2 showed potent antioxidant activity even stronger than the positive control. Among both the compounds, mildbone (1) was found to be potent in both the assays.
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