Published January 1, 2012
| Version v1
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Increased Tau Phosphorylation and Impaired Presynaptic Function in Hypertriglyceridemic ApoB-100 Transgenic Mice
Creators
- 1. Hungarian Acad Sci, Biol Res Ctr, Inst Biochem, H-6701 Szeged, Hungary
- 2. Bay Zoltan Fdn Appl Res, Inst Plant Genom Human Biotechnol & Bioenergy, Szeged, Hungary
- 3. Univ Szeged, Inst Med Chem, Fac Med, Szeged, Hungary
Description
Aims: ApoB-100 is the major protein component of cholesterol- and triglyceride-rich LDL and VLDL lipoproteins in the serum. Previously, we generated and partially described transgenic mice overexpressing the human ApoB-100 protein. Here, we further characterize this transgenic strain in order to reveal a possible link between hypeprlipidemia and neurodegeneration.
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