Published January 1, 2015
| Version v1
Journal article
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Changes to the dynamic nature of hemagglutinin and the emergence of the 2009 pandemic H1N1 influenza virus
Creators
- 1. Tel Aviv Univ, George S Wise Fac Life Sci, Dept Biochem & Mol Biol, IL-69978 Tel Aviv, Israel
- 2. Scripps Res Inst, Dept Chem Physiol, La Jolla, CA 92037 USA
- 3. St Jude Childrens Res Hosp, Dept Infect Dis, Div Virol, Memphis, TN 38105 USA
- 4. Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98109 USA
Description
The virologic factors that limit the transmission of swine influenza viruses between humans are unresolved. While it has been shown that acquisition of the neuraminidase (NA) and matrix (M) gene segments from a Eurasian-lineage swine virus was required for airborne transmission of the 2009 pandemic H1N1 virus (H1N1pdm09), we show here that an arginine to lysine change in the hemagglutinin (HA) was also necessary. This change at position 149 was distal to the receptor binding site but affected virus-receptor affinity and HA dynamics, allowing the virus to replicate more efficiently in nasal turbinate epithelium and subsequently transmit between ferrets. Receptor affinity should be considered as a factor limiting swine virus spread in humans.
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