Published January 1, 2015
| Version v1
Journal article
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Transgelin gene is frequently downregulated by promoter DNA hypermethylation in breast cancer
Creators
- 1. Bilkent Univ, Dept Mol Biol & Genet, Fac Sci, TR-06800 Ankara, Turkey
- 2. Ankara Numune Training & Res Hosp, Dept Gen Surg, TR-06100 Ankara, Turkey
- 3. Ankara Numune Training & Res Hosp, Dept Pathol, TR-06100 Ankara, Turkey
Description
Background: CpG hypermethylation in gene promoters is a frequent mechanism of tumor suppressor gene silencing in various types of cancers. It usually occurs at early steps of cancer progression and can be detected easily, giving rise to development of promising biomarkers for both detection and progression of cancer, including breast cancer. 5-aza-2'-deoxycytidine (AZA) is a DNA demethylating and anti-cancer agent resulting in induction of genes suppressed via DNA hypermethylation.
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