Published January 1, 2014
| Version v1
Journal article
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Up-regulation of TGM2 with ITGB1 and SDC4 is important in the development and metastasis of renal cell carcinoma
Creators
- 1. Yeditepe Univ, Dept Genet & Bioengn, Istanbul, Turkey
- 2. Istanbul Univ, Dept Urol, Istanbul, Turkey
- 3. Yeditepe Univ, Dept Syst Engn, Istanbul, Turkey
- 4. Istanbul Univ, Dept Pathol, Istanbul, Turkey
Description
Objective: Tissue transglutaminase (TGM2) up-regulation is involved in the progression and dissemination of carcinomas through 131 integrin (ITGB1) association. Given that TGM2 interaction with syndecan-4 (SDC4) on the cell surface is important in the activation of ITGB1 and integrin-mediated survival signaling, we investigated the roles of TG.M2. ITGB1, and SDC4 in the development and metastasis of renal cell carcinoma (RUC).
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