1 Ocak 2019 Dergi makalesi Açık Erişim

Oran, D. C.; Lokumcu, T.; Inceoglu, Y.; Akolpoglu, M. B.; Albayrak, O.; Bal, T.; Kurtoglu, M.; Erkan, M.; Can, F.; Bagci-Onder, T.; Kizilel, S.

JSON

{
  "conceptrecid": "71560", 
  "created": "2021-03-16T03:30:45.919757+00:00", 
  "doi": "10.1016/j.mtbio.2019.100006", 
  "files": [
    {
      "bucket": "b2c084e1-8adc-4589-a97d-fa2322c15a17", 
      "checksum": "md5:1a05516b46ed135294fa06be826d95c3", 
      "key": "bib-9dbec385-cd87-4e9c-9604-610d5dacc99f.txt", 
      "links": {
        "self": "https://aperta.ulakbim.gov.tr/api/files/b2c084e1-8adc-4589-a97d-fa2322c15a17/bib-9dbec385-cd87-4e9c-9604-610d5dacc99f.txt"
      }, 
      "size": 295, 
      "type": "txt"
    }
  ], 
  "id": 71561, 
  "links": {
    "badge": "https://aperta.ulakbim.gov.tr/badge/doi/10.1016/j.mtbio.2019.100006.svg", 
    "bucket": "https://aperta.ulakbim.gov.tr/api/files/b2c084e1-8adc-4589-a97d-fa2322c15a17", 
    "doi": "https://doi.org/10.1016/j.mtbio.2019.100006", 
    "html": "https://aperta.ulakbim.gov.tr/record/71561", 
    "latest": "https://aperta.ulakbim.gov.tr/api/records/71561", 
    "latest_html": "https://aperta.ulakbim.gov.tr/record/71561"
  }, 
  "metadata": {
    "access_right": "open", 
    "access_right_category": "success", 
    "communities": [
      {
        "id": "tubitak-destekli-proje-yayinlari"
      }
    ], 
    "creators": [
      {
        "affiliation": "Koc Univ, Biomed Sci & Engn, TR-34450 Istanbul, Turkey", 
        "name": "Oran, D. C."
      }, 
      {
        "affiliation": "Koc Univ, Biomed Sci & Engn, TR-34450 Istanbul, Turkey", 
        "name": "Lokumcu, T."
      }, 
      {
        "affiliation": "Koc Univ, Chem & Biol Engn, TR-34450 Istanbul, Turkey", 
        "name": "Inceoglu, Y."
      }, 
      {
        "affiliation": "Koc Univ, Chem & Biol Engn, TR-34450 Istanbul, Turkey", 
        "name": "Akolpoglu, M. B."
      }, 
      {
        "affiliation": "Koc Univ, Sch Med, Med Microbiol, TR-34450 Istanbul, Turkey", 
        "name": "Albayrak, O."
      }, 
      {
        "affiliation": "Koc Univ, Biomed Sci & Engn, TR-34450 Istanbul, Turkey", 
        "name": "Bal, T."
      }, 
      {
        "name": "Kurtoglu, M."
      }, 
      {
        "name": "Erkan, M."
      }, 
      {
        "name": "Can, F."
      }, 
      {
        "name": "Bagci-Onder, T."
      }, 
      {
        "name": "Kizilel, S."
      }
    ], 
    "description": "Type 1 diabetes (T1D) is an autoimmune disease characterized by destruction of pancreatic beta cells. One of the promising therapeutic approaches in T1D is the transplantation of islets; however, it has serious limitations. To address these limitations, immunotherapeutic strategies have focused on restoring immunologic tolerance, preventing transplanted cell destruction by patients' own immune system. Macrophage-derived chemokines such as chemokine-ligand-22 (CCL22) can be utilized for regulatory T cell (Treg) recruitment and graft tolerance. Stellate cells (SCs) have various immunomodulatory functions: recruitment of Tregs and induction of T-cell apoptosis. Here, we designed a unique immune-privileged microenvironment around implantable islets through overexpression of CCL22 proteins by SCs. We prepared pseudoislets with insulin-secreting mouse insulinoma-6 (MIN6) cells and human SCs as a model to mimic naive islet morphology. Our results demonstrated that transduced SCs can secrete CCL22 and recruit Tregs toward the implantation site in vivo. This study is promising to provide a fundamental understanding of SC-islet interaction and ligand synthesis and transport from SCs at the graft site for ensuring local immune tolerance. Our results also establish a new paradigm for creating tolerable grafts for other chronic diseases such as diabetes, anemia, and central nervous system (CNS) diseases, and advance the science of graft tolerance.", 
    "doi": "10.1016/j.mtbio.2019.100006", 
    "has_grant": false, 
    "journal": {
      "title": "MATERIALS TODAY BIO", 
      "volume": "2"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2019-01-01", 
    "relations": {
      "version": [
        {
          "count": 1, 
          "index": 0, 
          "is_last": true, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "71561"
          }, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "71560"
          }
        }
      ]
    }, 
    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
    }, 
    "title": "Engineering human stellate cells for beta cell replacement therapy promotes in vivo recruitment of regulatory T cells"
  }, 
  "owners": [
    1
  ], 
  "revision": 1, 
  "stats": {
    "downloads": 6.0, 
    "unique_downloads": 6.0, 
    "unique_views": 35.0, 
    "version_downloads": 6.0, 
    "version_unique_downloads": 6.0, 
    "version_unique_views": 35.0, 
    "version_views": 37.0, 
    "version_volume": 1770.0, 
    "views": 37.0, 
    "volume": 1770.0
  }, 
  "updated": "2021-03-16T03:30:45.963532+00:00"
}