1 Ocak 2019 Dergi makalesi Açık Erişim

Abidin, Ismail; Aydin-Abidin, Selcen; Mittmann, Thomas

DataCite XML

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/71111</identifier>
  <creators>
    <creator>
      <creatorName>Abidin, Ismail</creatorName>
      <givenName>Ismail</givenName>
      <familyName>Abidin</familyName>
      <affiliation>Karadeniz Tech Univ, Dept Biophys, Fac Med, Trabzon, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Aydin-Abidin, Selcen</creatorName>
      <givenName>Selcen</givenName>
      <familyName>Aydin-Abidin</familyName>
      <affiliation>Karadeniz Tech Univ, Dept Biophys, Fac Med, Trabzon, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Mittmann, Thomas</creatorName>
      <givenName>Thomas</givenName>
      <familyName>Mittmann</familyName>
      <affiliation>Johannes Gutenberg Univ Mainz, UMC, Inst Physiol &amp; Pathophysiol, Mainz, Germany</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Neuronal Excitability And Spontaneous Synaptic Transmission In The Entorhinal Cortex Of Bdnf Heterozygous Mice</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/71111</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.neulet.2018.10.019</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Brain Derived Neurotropic Factor (BDNF) is a neutrophic factor that is required for the normal neuronal development and function. BDNF is involved in regulation of synapses as well as neuronal excitability. Entorhinal Cortex (EC) is a key brain area involved in many physiological and pathological processes. In this study we investigated the effects of chronically reduced BDNF levels on layer 3 pyramidal neurons of EC. We aimed to assess the effects of reduced levels of BDNF on firing properties, spontaneous synaptic currents and excitation/inhibition balance from acute brain slices. Patch clamp recordings were obtained from pyramidal neurons of Entorhinal Cortex Layer 3. Findings of BDNF heterozygous (BDNF (+ / -) mice compared to their wild-type littermates at the age of 23-28 days. Action potential threshold was shifted (p = 0,002) to depolarized potentials and spike frequency was smaller in response to somatic current injection steps in BDNF (+ / -) mice. Spontaneous synaptic currents were also affected. sEPSC amplitude (p = 0,009), sIPSC frequency (p = 0,001) and sIPSC amplitudes (p = 0,023) were reduced in BDNF (+ / -). Decay times of sIPSCs were longer in BDNF (+ / -) (p = 0,014). Calculated balance of excitatory/inhibitory balance was shifted in the favor of excitation in BDNF (+ / -) mice (p = 0,01). These findings suggest that reductions in concentrations of BDNF results in altered status of excitability and excitation/inhibition imbalance. However, these differences observed in BDNF (+/ -) seem to have opposing effects on neuronal activity.</description>
  </descriptions>
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