1 Ocak 2019 Dergi makalesi Açık Erişim

Abidin, Ismail; Aydin-Abidin, Selcen; Mittmann, Thomas

Citation Style Language JSON

{
  "DOI": "10.1016/j.neulet.2018.10.019", 
  "abstract": "Brain Derived Neurotropic Factor (BDNF) is a neutrophic factor that is required for the normal neuronal development and function. BDNF is involved in regulation of synapses as well as neuronal excitability. Entorhinal Cortex (EC) is a key brain area involved in many physiological and pathological processes. In this study we investigated the effects of chronically reduced BDNF levels on layer 3 pyramidal neurons of EC. We aimed to assess the effects of reduced levels of BDNF on firing properties, spontaneous synaptic currents and excitation/inhibition balance from acute brain slices. Patch clamp recordings were obtained from pyramidal neurons of Entorhinal Cortex Layer 3. Findings of BDNF heterozygous (BDNF (+ / -) mice compared to their wild-type littermates at the age of 23-28 days. Action potential threshold was shifted (p = 0,002) to depolarized potentials and spike frequency was smaller in response to somatic current injection steps in BDNF (+ / -) mice. Spontaneous synaptic currents were also affected. sEPSC amplitude (p = 0,009), sIPSC frequency (p = 0,001) and sIPSC amplitudes (p = 0,023) were reduced in BDNF (+ / -). Decay times of sIPSCs were longer in BDNF (+ / -) (p = 0,014). Calculated balance of excitatory/inhibitory balance was shifted in the favor of excitation in BDNF (+ / -) mice (p = 0,01). These findings suggest that reductions in concentrations of BDNF results in altered status of excitability and excitation/inhibition imbalance. However, these differences observed in BDNF (+/ -) seem to have opposing effects on neuronal activity.", 
  "author": [
    {
      "family": "Abidin", 
      "given": " Ismail"
    }, 
    {
      "family": "Aydin-Abidin", 
      "given": " Selcen"
    }, 
    {
      "family": "Mittmann", 
      "given": " Thomas"
    }
  ], 
  "container_title": "NEUROSCIENCE LETTERS", 
  "id": "71111", 
  "issued": {
    "date-parts": [
      [
        2019, 
        1, 
        1
      ]
    ]
  }, 
  "page": "69-75", 
  "title": "Neuronal excitability and spontaneous synaptic transmission in the entorhinal cortex of BDNF heterozygous mice", 
  "type": "article-journal", 
  "volume": "690"
}