1 Ocak 2019 Dergi makalesi Açık Erişim

Altinelataman, Can; Koroleva, Olga; Fedorova, Tatyana; Torkova, Anna; Lisitskaya, Ksenia; Tsentalovich, Mikhail; Kononikhin, Aleksey; Popov, Igor; Vasina, Dania; Kovalyov, Leonid; Celik, Ufuk

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{
  "DOI": "10.1016/j.foodchem.2018.08.004", 
  "abstract": "European seabass (Dicentrarchus labrax, Linnaeus, 1758) (L) and gilthead seabream (Spares aurata, Linnaeus, 1758) (C) muscles were hydrolysated by Alcalase (L-alc, C-alc) and Chymotrypsin (L-ch, C-ch) then hydrolysates were examined and their peptide profiles obtained. A total of 765, 794, 132 and 232 peptides were identified in C-alc, L-alc, C-ch, and L-ch, respectively. Although, L-ch and C-ch, were expected to have more antioxidant capacity because of their peptide profiles, Alcalase hydrolysates observed in vitro, were slightly higher (TEAC assay for C-alc: 848.11 +/- 60.78 cool TE/g protein). Maximum inhibition of oxidative stress was determined for L-alc (12.8% +/- 4.5%) in MDCK1 cell lines. Highest proliferative capacity observed for C-alc (147.0% +/- 3.1%) at MTT assay in MDCK1 cell culture. L-ch showed the highest chemopreventive effect with a 40-60% decrease for human colon adenocarcinoma cell line HT-29. This research points out the importance of aquatic sources as raw materials for peptide researches.", 
  "author": [
    {
      "family": "Altinelataman", 
      "given": " Can"
    }, 
    {
      "family": "Koroleva", 
      "given": " Olga"
    }, 
    {
      "family": "Fedorova", 
      "given": " Tatyana"
    }, 
    {
      "family": "Torkova", 
      "given": " Anna"
    }, 
    {
      "family": "Lisitskaya", 
      "given": " Ksenia"
    }, 
    {
      "family": "Tsentalovich", 
      "given": " Mikhail"
    }, 
    {
      "family": "Kononikhin", 
      "given": " Aleksey"
    }, 
    {
      "family": "Popov", 
      "given": " Igor"
    }, 
    {
      "family": "Vasina", 
      "given": " Dania"
    }, 
    {
      "family": "Kovalyov", 
      "given": " Leonid"
    }, 
    {
      "family": "Celik", 
      "given": " Ufuk"
    }
  ], 
  "container_title": "FOOD CHEMISTRY", 
  "id": "67903", 
  "issued": {
    "date-parts": [
      [
        2019, 
        1, 
        1
      ]
    ]
  }, 
  "page": "724-732", 
  "title": "An in vitro and in silico study on the antioxidant and cell culture-based study on the chemoprotective activities of fish muscle protein hydrolysates obtained from European seabass and gilthead seabream", 
  "type": "article-journal", 
  "volume": "271"
}