1 Ocak 2020 Dergi makalesi Açık Erişim

Afghah, Ferdows; Ullah, Mohib; Zanjani, Jamal Seyyed Monfared; Sut, Pinar Akkus; Sen, Ozlem; Emanet, Melis; Okan, Burcu Saner; Culha, Mustafa; Menceloglu, Yusuf; Yildiz, Mehmet; Koc, Bahattin

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/6437</identifier>
  <creators>
    <creator>
      <creatorName>Afghah, Ferdows</creatorName>
      <givenName>Ferdows</givenName>
      <familyName>Afghah</familyName>
    </creator>
    <creator>
      <creatorName>Ullah, Mohib</creatorName>
      <givenName>Mohib</givenName>
      <familyName>Ullah</familyName>
      <affiliation>Gomal Univ, Inst Chem Sci, Islamabad 29220, KP, Pakistan</affiliation>
    </creator>
    <creator>
      <creatorName>Zanjani, Jamal Seyyed Monfared</creatorName>
      <givenName>Jamal Seyyed Monfared</givenName>
      <familyName>Zanjani</familyName>
      <affiliation>Univ Twente, Fac Engn Technol, NL-7500 AE Enschede, Netherlands</affiliation>
    </creator>
    <creator>
      <creatorName>Sut, Pinar Akkus</creatorName>
      <givenName>Pinar Akkus</givenName>
      <familyName>Sut</familyName>
      <affiliation>Yeditepe Univ, Fac Engn, Dept Genet &amp; Bioengn, TR-34755 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sen, Ozlem</creatorName>
      <givenName>Ozlem</givenName>
      <familyName>Sen</familyName>
      <affiliation>Yeditepe Univ, Fac Engn, Dept Genet &amp; Bioengn, TR-34755 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Emanet, Melis</creatorName>
      <givenName>Melis</givenName>
      <familyName>Emanet</familyName>
      <affiliation>Yeditepe Univ, Fac Engn, Dept Genet &amp; Bioengn, TR-34755 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Okan, Burcu Saner</creatorName>
      <givenName>Burcu Saner</givenName>
      <familyName>Okan</familyName>
      <affiliation>Sabanci Univ, Integrated Mfg Technol Res &amp; Applicat Ctr, TR-34906 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Culha, Mustafa</creatorName>
      <givenName>Mustafa</givenName>
      <familyName>Culha</familyName>
      <affiliation>Sabanci Univ, Integrated Mfg Technol Res &amp; Applicat Ctr, TR-34906 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Menceloglu, Yusuf</creatorName>
      <givenName>Yusuf</givenName>
      <familyName>Menceloglu</familyName>
    </creator>
    <creator>
      <creatorName>Yildiz, Mehmet</creatorName>
      <givenName>Mehmet</givenName>
      <familyName>Yildiz</familyName>
    </creator>
    <creator>
      <creatorName>Koc, Bahattin</creatorName>
      <givenName>Bahattin</givenName>
      <familyName>Koc</familyName>
    </creator>
  </creators>
  <titles>
    <title>3D Printing Of Silver-Doped Polycaprolactone-Poly(Propylene Succinate) Composite Scaffolds For Skin Tissue Engineering</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2020</publicationYear>
  <dates>
    <date dateType="Issued">2020-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/6437</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1088/1748-605X/ab7417</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Scaffold-based tissue engineering approaches have been commonly used for skin regeneration or wound healings caused by diseases or trauma. For an ideal complete healing process, scaffold structures need to meet the criteria of biocompatibility, biodegradability, and antimicrobial properties, as well as to provide geometrical necessities for the regeneration of damaged tissue. In this study, design, synthesis and characterization of a three dimensional (3D) printable copolymer based on polycaprolactone-block-poly(1,3-propylene succinate) (PCL-PPSu) including anti-microbial silver particles is presented. 3D printing of PCL-PPSu copolymers provided a lower processing temperature compared to neat PCL, hence, inclusion of temperature-sensitive bioactive reagents into the developed copolymer could be realized. In addition, 3D printed block copolymer showed an enhanced hydrolytic and enzymatic degradation behavior. Cell viability and cytotoxicity of the developed copolymer were evaluated by using human dermal fibroblast (HDF) cells. The addition of silver nitrate within the polymer matrix resulted in a significant decrease in the adhesion of different types of microorganisms on the scaffold without inducing any cytotoxicity on HDF cells in vitro. The results suggested that 3D printed PCL-PPSu scaffolds containing anti-microbial silver particles could be considered as a promising biomaterial for emerging skin regenerative therapies, in the light of its adaptability to 3D printing technology, low-processing temperature, enhanced degradation behavior and antimicrobial properties.</description>
  </descriptions>
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