Dergi makalesi Açık Erişim
Tosun, Haci Bayram; Gurger, Murat; Gumustas, Seyit Ali; Uludag, Abuzer; Ucer, Ozlem; Serbest, Sancar; Celik, Suat
Objective: In focal cartilage lesions, multipotent mesenchymal stem cells in bone marrow are aimed to be moved into the defect area using subchondral drilling or microfracture method. However, repaired tissue insufficiently fills the defect area or cannot meet natural hyaline tissue functions, due to fibrous structure. We investigated the effect of a combined solution of sodium hyaluronate + chondroitin sulfate (HA+CS) administered intra-articularly after subchondral drilling on newly formed cartilage in rabbits with focal osteochondral defects.
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