Dergi makalesi Açık Erişim

Formulation and characterization of tissue scaffolds containing simvastatin loaded nanostructured lipid carriers for treatment of diabetic wounds

2017    Orgul, Dilara; Eroglu, Hakan; Hekimoglu, Sueda

The objective of the present investigation was to develop novel three-dimensional (3D) and biodegradable tissue scaffolds (TSs), consisting of biological polymers and simvastatin. (SV)-loaded nano structured lipid carriers (NLCs) for the treatment of diabetic wounds. NLCs were prepared via high-shear homogenization and freeze-drying was used for NLC-incorporated TSs. The resulting NLC suspension contained spherical nanosized (110-158 nm) homogeneous particles (PDI<0.16) with >99% encapsulation efficiency. The NLCs were characterized via differential scanning calorimetry and Fourier transfcirm infrared spectroscopy analysis. TSs have 3D high porous structure (74.38%) and sufficient large pore size (similar to 100-200 gm), low weight loss (57.7%), high absorption capacity (710.88%) and good mechanical strength. Incorporation of NLCs into TSs delayed the initial SV release and generated a more controlled release profile. Biocompatibility of the TSs was shown using MTT assay. The results suggest that TSs cad be considered as suitable candidates for diabetic wound treatment. (C) 2017 Elsevier B.V. All rights reserved.