1 Ocak 2017 Dergi makalesi Açık Erişim

Uygun, Murat; Jurado-Sanchez, Beatriz; Uygun, Deniz Aktas; Singh, Virendra Vikram; Zhang, Liangfang; Wang, Joseph

DataCite XML

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/45319</identifier>
  <creators>
    <creator>
      <creatorName>Uygun, Murat</creatorName>
      <givenName>Murat</givenName>
      <familyName>Uygun</familyName>
    </creator>
    <creator>
      <creatorName>Jurado-Sanchez, Beatriz</creatorName>
      <givenName>Beatriz</givenName>
      <familyName>Jurado-Sanchez</familyName>
    </creator>
    <creator>
      <creatorName>Uygun, Deniz Aktas</creatorName>
      <givenName>Deniz Aktas</givenName>
      <familyName>Uygun</familyName>
    </creator>
    <creator>
      <creatorName>Singh, Virendra Vikram</creatorName>
      <givenName>Virendra Vikram</givenName>
      <familyName>Singh</familyName>
      <affiliation>Univ Calif San Diego, Dept Nanoengn, La Jolla, CA 92093 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Zhang, Liangfang</creatorName>
      <givenName>Liangfang</givenName>
      <familyName>Zhang</familyName>
      <affiliation>Univ Calif San Diego, Dept Nanoengn, La Jolla, CA 92093 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Wang, Joseph</creatorName>
      <givenName>Joseph</givenName>
      <familyName>Wang</familyName>
      <affiliation>Univ Calif San Diego, Dept Nanoengn, La Jolla, CA 92093 USA</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Ultrasound-Propelled Nanowire Motors Enhance Asparaginase Enzymatic Activity Against Cancer Cells</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2017</publicationYear>
  <dates>
    <date dateType="Issued">2017-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/45319</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1039/c7nr07396h</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Ultrasound-(US) propelled nanowires consisting of Au/Ni/Au/PEDOT-PPy-COOH segments are modified with asparaginase enzyme and applied as an effective anti-cancer agent. After immobilization of asparaginase onto the surface of the nanowire motors, the enzyme displays enhanced thermal and pH stabilities, improved resistance towards protease, and higher affinity for the substrate. The fast motion of the motorcarrying asparaginase leads to greatly accelerated biocatalytic depletion of asparagine and hence to a significantly enhanced inhibition efficacy against El4 lymphoma cancer cells (92%) as compared to free enzyme counterpart (17%) and other control groups. Such enhanced enzymatic activity against cancer cells is attributed to the fast motion of the motors which facilitates the interaction between the enzyme and the cancer cells. While asparaginase and EL4 tumor cells are used as a model system in the present study for cancer cell inhibition, the same mechanism can be expanded to other types of enzymes and biomolecules for the corresponding biofunctions.</description>
  </descriptions>
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