1 Ocak 2020 Dergi makalesi Açık Erişim

Demircan, Muhammed Burak; Tohumeken, Sehmus; Gunduz, Nuray; Khalily, Mohammad Aref; Tekinay, Turgay; Guler, Mustafa O.; Tekinay, Ayse B.

Dublin Core

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  <dc:creator>Demircan, Muhammed Burak</dc:creator>
  <dc:creator>Tohumeken, Sehmus</dc:creator>
  <dc:creator>Gunduz, Nuray</dc:creator>
  <dc:creator>Khalily, Mohammad Aref</dc:creator>
  <dc:creator>Tekinay, Turgay</dc:creator>
  <dc:creator>Guler, Mustafa O.</dc:creator>
  <dc:creator>Tekinay, Ayse B.</dc:creator>
  <dc:date>2020-01-01</dc:date>
  <dc:description>Biotinylated peptide amphiphile (Biotin-PA) nanofibers, are designed as a noncovalent binding location for antigens, which are adjuvants to enhance, accelerate, and prolong the immune response triggered by antigens. Presenting antigens on synthetic Biotin-PA nanofibers generated a higher immune response than the free antigens delivered with a cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODN) (TLR9 agonist) adjuvant. Antigen attached Biotin-PA nanofibers trigger splenocytes to produce high levels of cytokines (IFN-gamma, IL-12, TNF-alpha, and IL-6) and to exhibit a superior cross-presentation of the antigen. Both Biotin-PA nanofibers and CpG ODN induce a Th-1-biased IgG subclass response; however, delivering the antigen with Biotin-PA nanofibers induce significantly greater production of total IgG and subclasses of IgG compared to delivering the antigen with CpG ODN. Contrary to CpG ODN, Biotin-PA nanofibers also enhance antigen-specific splenocyte proliferation and increase the proportion of the antigen-specific CD8(+) T cells. Given their biodegradability and biocompatibility, Biotin-PA nanofibers have a significant potential in immunoengineering applications as a biomaterial for the delivery of a diverse set of antigens derived from intracellular pathogens, emerging viral diseases such as COVID-19, or cancer cells to induce humoral and cellular immune responses against the antigens.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/4107</dc:identifier>
  <dc:identifier>oai:zenodo.org:4107</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>BIOTECHNOLOGY JOURNAL 15(12)</dc:source>
  <dc:title>Biotin Functionalized Self-Assembled Peptide Nanofiber as an Adjuvant for Immunomodulatory Response</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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