Dergi makalesi Açık Erişim
Demircan, Muhammed Burak; Tohumeken, Sehmus; Gunduz, Nuray; Khalily, Mohammad Aref; Tekinay, Turgay; Guler, Mustafa O.; Tekinay, Ayse B.
{ "@context": "https://schema.org/", "@id": 4107, "@type": "ScholarlyArticle", "creator": [ { "@type": "Person", "name": "Demircan, Muhammed Burak" }, { "@type": "Person", "name": "Tohumeken, Sehmus" }, { "@type": "Person", "name": "Gunduz, Nuray" }, { "@type": "Person", "affiliation": "Bilkent Univ, Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey", "name": "Khalily, Mohammad Aref" }, { "@type": "Person", "affiliation": "Gazi Univ, TR-06100 Ankara, Turkey", "name": "Tekinay, Turgay" }, { "@type": "Person", "affiliation": "Univ Chicago, Pritzker Sch Mol Engn, Chicago, IL 60637 USA", "name": "Guler, Mustafa O." }, { "@type": "Person", "name": "Tekinay, Ayse B." } ], "datePublished": "2020-01-01", "description": "Biotinylated peptide amphiphile (Biotin-PA) nanofibers, are designed as a noncovalent binding location for antigens, which are adjuvants to enhance, accelerate, and prolong the immune response triggered by antigens. Presenting antigens on synthetic Biotin-PA nanofibers generated a higher immune response than the free antigens delivered with a cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODN) (TLR9 agonist) adjuvant. Antigen attached Biotin-PA nanofibers trigger splenocytes to produce high levels of cytokines (IFN-gamma, IL-12, TNF-alpha, and IL-6) and to exhibit a superior cross-presentation of the antigen. Both Biotin-PA nanofibers and CpG ODN induce a Th-1-biased IgG subclass response; however, delivering the antigen with Biotin-PA nanofibers induce significantly greater production of total IgG and subclasses of IgG compared to delivering the antigen with CpG ODN. Contrary to CpG ODN, Biotin-PA nanofibers also enhance antigen-specific splenocyte proliferation and increase the proportion of the antigen-specific CD8(+) T cells. Given their biodegradability and biocompatibility, Biotin-PA nanofibers have a significant potential in immunoengineering applications as a biomaterial for the delivery of a diverse set of antigens derived from intracellular pathogens, emerging viral diseases such as COVID-19, or cancer cells to induce humoral and cellular immune responses against the antigens.", "headline": "Biotin Functionalized Self-Assembled Peptide Nanofiber as an Adjuvant for Immunomodulatory Response", "identifier": 4107, "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", "license": "http://www.opendefinition.org/licenses/cc-by", "name": "Biotin Functionalized Self-Assembled Peptide Nanofiber as an Adjuvant for Immunomodulatory Response", "url": "https://aperta.ulakbim.gov.tr/record/4107" }
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