1 Ocak 2020 Dergi makalesi Açık Erişim

Demircan, Muhammed Burak; Tohumeken, Sehmus; Gunduz, Nuray; Khalily, Mohammad Aref; Tekinay, Turgay; Guler, Mustafa O.; Tekinay, Ayse B.

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        "name": "Demircan, Muhammed Burak"
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      {
        "name": "Gunduz, Nuray"
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        "affiliation": "Bilkent Univ, Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey", 
        "name": "Khalily, Mohammad Aref"
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      {
        "affiliation": "Gazi Univ, TR-06100 Ankara, Turkey", 
        "name": "Tekinay, Turgay"
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      {
        "affiliation": "Univ Chicago, Pritzker Sch Mol Engn, Chicago, IL 60637 USA", 
        "name": "Guler, Mustafa O."
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    "description": "Biotinylated peptide amphiphile (Biotin-PA) nanofibers, are designed as a noncovalent binding location for antigens, which are adjuvants to enhance, accelerate, and prolong the immune response triggered by antigens. Presenting antigens on synthetic Biotin-PA nanofibers generated a higher immune response than the free antigens delivered with a cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODN) (TLR9 agonist) adjuvant. Antigen attached Biotin-PA nanofibers trigger splenocytes to produce high levels of cytokines (IFN-gamma, IL-12, TNF-alpha, and IL-6) and to exhibit a superior cross-presentation of the antigen. Both Biotin-PA nanofibers and CpG ODN induce a Th-1-biased IgG subclass response; however, delivering the antigen with Biotin-PA nanofibers induce significantly greater production of total IgG and subclasses of IgG compared to delivering the antigen with CpG ODN. Contrary to CpG ODN, Biotin-PA nanofibers also enhance antigen-specific splenocyte proliferation and increase the proportion of the antigen-specific CD8(+) T cells. Given their biodegradability and biocompatibility, Biotin-PA nanofibers have a significant potential in immunoengineering applications as a biomaterial for the delivery of a diverse set of antigens derived from intracellular pathogens, emerging viral diseases such as COVID-19, or cancer cells to induce humoral and cellular immune responses against the antigens.", 
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      "title": "BIOTECHNOLOGY JOURNAL", 
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    "title": "Biotin Functionalized Self-Assembled Peptide Nanofiber as an Adjuvant for Immunomodulatory Response"
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