1 Ocak 2020 Dergi makalesi Açık Erişim

Demircan, Muhammed Burak; Tohumeken, Sehmus; Gunduz, Nuray; Khalily, Mohammad Aref; Tekinay, Turgay; Guler, Mustafa O.; Tekinay, Ayse B.

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/4107</identifier>
  <creators>
    <creator>
      <creatorName>Demircan, Muhammed Burak</creatorName>
      <givenName>Muhammed Burak</givenName>
      <familyName>Demircan</familyName>
    </creator>
    <creator>
      <creatorName>Tohumeken, Sehmus</creatorName>
      <givenName>Sehmus</givenName>
      <familyName>Tohumeken</familyName>
    </creator>
    <creator>
      <creatorName>Gunduz, Nuray</creatorName>
      <givenName>Nuray</givenName>
      <familyName>Gunduz</familyName>
    </creator>
    <creator>
      <creatorName>Khalily, Mohammad Aref</creatorName>
      <givenName>Mohammad Aref</givenName>
      <familyName>Khalily</familyName>
      <affiliation>Bilkent Univ, Inst Mat Sci &amp; Nanotechnol, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tekinay, Turgay</creatorName>
      <givenName>Turgay</givenName>
      <familyName>Tekinay</familyName>
      <affiliation>Gazi Univ, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Guler, Mustafa O.</creatorName>
      <givenName>Mustafa O.</givenName>
      <familyName>Guler</familyName>
      <affiliation>Univ Chicago, Pritzker Sch Mol Engn, Chicago, IL 60637 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Tekinay, Ayse B.</creatorName>
      <givenName>Ayse B.</givenName>
      <familyName>Tekinay</familyName>
    </creator>
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  <titles>
    <title>Biotin Functionalized Self-Assembled Peptide Nanofiber As An Adjuvant For Immunomodulatory Response</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2020</publicationYear>
  <dates>
    <date dateType="Issued">2020-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/4107</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1002/biot.202000100</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Biotinylated peptide amphiphile (Biotin-PA) nanofibers, are designed as a noncovalent binding location for antigens, which are adjuvants to enhance, accelerate, and prolong the immune response triggered by antigens. Presenting antigens on synthetic Biotin-PA nanofibers generated a higher immune response than the free antigens delivered with a cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODN) (TLR9 agonist) adjuvant. Antigen attached Biotin-PA nanofibers trigger splenocytes to produce high levels of cytokines (IFN-gamma, IL-12, TNF-alpha, and IL-6) and to exhibit a superior cross-presentation of the antigen. Both Biotin-PA nanofibers and CpG ODN induce a Th-1-biased IgG subclass response; however, delivering the antigen with Biotin-PA nanofibers induce significantly greater production of total IgG and subclasses of IgG compared to delivering the antigen with CpG ODN. Contrary to CpG ODN, Biotin-PA nanofibers also enhance antigen-specific splenocyte proliferation and increase the proportion of the antigen-specific CD8(+) T cells. Given their biodegradability and biocompatibility, Biotin-PA nanofibers have a significant potential in immunoengineering applications as a biomaterial for the delivery of a diverse set of antigens derived from intracellular pathogens, emerging viral diseases such as COVID-19, or cancer cells to induce humoral and cellular immune responses against the antigens.</description>
  </descriptions>
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