1 Ocak 2020 Dergi makalesi Açık Erişim

Demircan, Muhammed Burak; Tohumeken, Sehmus; Gunduz, Nuray; Khalily, Mohammad Aref; Tekinay, Turgay; Guler, Mustafa O.; Tekinay, Ayse B.

Citation Style Language JSON

{
  "DOI": "10.1002/biot.202000100", 
  "abstract": "Biotinylated peptide amphiphile (Biotin-PA) nanofibers, are designed as a noncovalent binding location for antigens, which are adjuvants to enhance, accelerate, and prolong the immune response triggered by antigens. Presenting antigens on synthetic Biotin-PA nanofibers generated a higher immune response than the free antigens delivered with a cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODN) (TLR9 agonist) adjuvant. Antigen attached Biotin-PA nanofibers trigger splenocytes to produce high levels of cytokines (IFN-gamma, IL-12, TNF-alpha, and IL-6) and to exhibit a superior cross-presentation of the antigen. Both Biotin-PA nanofibers and CpG ODN induce a Th-1-biased IgG subclass response; however, delivering the antigen with Biotin-PA nanofibers induce significantly greater production of total IgG and subclasses of IgG compared to delivering the antigen with CpG ODN. Contrary to CpG ODN, Biotin-PA nanofibers also enhance antigen-specific splenocyte proliferation and increase the proportion of the antigen-specific CD8(+) T cells. Given their biodegradability and biocompatibility, Biotin-PA nanofibers have a significant potential in immunoengineering applications as a biomaterial for the delivery of a diverse set of antigens derived from intracellular pathogens, emerging viral diseases such as COVID-19, or cancer cells to induce humoral and cellular immune responses against the antigens.", 
  "author": [
    {
      "family": "Demircan", 
      "given": " Muhammed Burak"
    }, 
    {
      "family": "Tohumeken", 
      "given": " Sehmus"
    }, 
    {
      "family": "Gunduz", 
      "given": " Nuray"
    }, 
    {
      "family": "Khalily", 
      "given": " Mohammad Aref"
    }, 
    {
      "family": "Tekinay", 
      "given": " Turgay"
    }, 
    {
      "family": "Guler", 
      "given": " Mustafa O."
    }, 
    {
      "family": "Tekinay", 
      "given": " Ayse B."
    }
  ], 
  "container_title": "BIOTECHNOLOGY JOURNAL", 
  "id": "4107", 
  "issue": "12", 
  "issued": {
    "date-parts": [
      [
        2020, 
        1, 
        1
      ]
    ]
  }, 
  "title": "Biotin Functionalized Self-Assembled Peptide Nanofiber as an Adjuvant for Immunomodulatory Response", 
  "type": "article-journal", 
  "volume": "15"
}