1 Ocak 2009 Dergi makalesi Açık Erişim

Hacariz, O.; Sayers, G.; Flynn, R. J.; Lejeune, A.; Mulcahy, G.

MARC21 XML

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">IL-10 and TGF-beta 1 are associated with variations in fluke burdens following experimental fasciolosis in sheep</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="4">
    <subfield code="p">PARASITE IMMUNOLOGY</subfield>
    <subfield code="v">31</subfield>
    <subfield code="n">10</subfield>
    <subfield code="c">613-622</subfield>
  </datafield>
  <controlfield tag="001">40959</controlfield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">P&amp;gt;Infection with Fasciola hepatica causes an economically important disease in ruminants. Variability in parasite load may indicate innate differences in the host immune system. This study aimed to investigate the immunological mechanisms that are associated with variability in parasite burden following experimental F. hepatica infection in cross-bred sheep. Of a total of 16 animals, four were randomly chosen as uninfected controls, and the remainder infected with 100 viable metacercariae. Uninfected animals were used as the control group for evaluation of cytokine gene expression levels. For comparative analysis, specific animals were selected on the basis of extremes of fluke burdens, and were categorised into light (n = 4) and heavy burdened (n = 3) cohorts. Serum antibody levels, haematological parameters, and expression of IL-4 and IFN-gamma genes in hepatic lymph nodes were equivalent in both groups. However, significant differences in mitogen-specific lymphocyte proliferation in vitro and in expression of TGF-beta 1 and IL-10 genes in hepatic lymph nodes were observed at acute and chronic phases of infection, respectively. These results provide useful information in developing further understanding of natural resistance to fasciolosis in sheep.</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="2">opendefinition.org</subfield>
    <subfield code="a">cc-by</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Univ Coll Dublin, Vet Sci Ctr, Sch Agr Food Sci &amp; Vet Med, Coll Life Sci, Dublin 4, Ireland</subfield>
    <subfield code="a">Sayers, G.</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">MRC, Mol Biol Lab, Cambridge CB2 2QH, England</subfield>
    <subfield code="a">Flynn, R. J.</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Univ Coll Dublin, Vet Sci Ctr, Sch Agr Food Sci &amp; Vet Med, Coll Life Sci, Dublin 4, Ireland</subfield>
    <subfield code="a">Lejeune, A.</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Univ Coll Dublin, Vet Sci Ctr, Sch Agr Food Sci &amp; Vet Med, Coll Life Sci, Dublin 4, Ireland</subfield>
    <subfield code="a">Mulcahy, G.</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="b">article</subfield>
    <subfield code="a">publication</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="u">Univ Coll Dublin, Vet Sci Ctr, Sch Agr Food Sci &amp; Vet Med, Coll Life Sci, Dublin 4, Ireland</subfield>
    <subfield code="a">Hacariz, O.</subfield>
  </datafield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2009-01-01</subfield>
  </datafield>
  <controlfield tag="005">20210315203522.0</controlfield>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="o">oai:zenodo.org:40959</subfield>
    <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="z">md5:114b02cd6e8e250b57ed8329c013a783</subfield>
    <subfield code="s">221</subfield>
    <subfield code="u">https://aperta.ulakbim.gov.trrecord/40959/files/bib-ab5fa365-f9cd-4cf5-835f-131cf2ec3641.txt</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield>
    <subfield code="a">Creative Commons Attribution</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.1111/j.1365-3024.2009.01135.x</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
</record>