1 Ocak 2024 Dergi makalesi Açık Erişim

Cakmak, Sude Saral; Erdogan, Omer; Basoglu, Faika; Coruh, Ufuk; Cevik, Ozge; Karakus, Sevgi

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  <dc:creator>Cakmak, Sude Saral</dc:creator>
  <dc:creator>Erdogan, Omer</dc:creator>
  <dc:creator>Basoglu, Faika</dc:creator>
  <dc:creator>Coruh, Ufuk</dc:creator>
  <dc:creator>Cevik, Ozge</dc:creator>
  <dc:creator>Karakus, Sevgi</dc:creator>
  <dc:date>2024-01-01</dc:date>
  <dc:description>Hydrazide-hydrazone derivatives have garnered significant interest from researchers globally due to their wide range of biological activities, including antiviral, anticancer, and anti-inflammatory properties. In this study, a novel series of etofenamate hydrazide-hydrazone compounds (2a-2s) and their Cu(II) complexes (3a-3s) were designed and synthesized. The compounds were characterized using various analytical techniques such as FT-IR, 1H NMR, 13C NMR, MS, and elemental analysis. Additionally, the compound 2c and Cu(II) hydrazone complex 3a were further characterized using single X-ray crystallography. The anti-proliferative activity of the compounds was evaluated against Ishikawa human endometrial cancer cell line and non-tumour L929 cells using MTT assay. Additionally, the apoptotic potential of the compounds was investigated through caspase-3 activity, Bax and Bcl2 gene expression analysis, and annexin-V binding. Furthermore, carbonic anhydrase IX activity and in silico studies were conducted to elucidate the mechanism of action. Overall, compound 3s demonstrated significant antiproliferative effects with an IC50 value of 0.27 +/- 0.01 mu M against Ishikawa cells.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/283851</dc:identifier>
  <dc:identifier>oai:aperta.ulakbim.gov.tr:283851</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>JOURNAL OF MOLECULAR STRUCTURE 1312 19</dc:source>
  <dc:title>Exploring etofenamate hydrazide-hydrazone/copper(II) complexes: Synthesis, anticancer activity, carbonic anhydrase IX inhibition and docking studies</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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