Bu kayıt için daha yeni bir sürüm var.

Dergi makalesi Açık Erişim

New imidazolidindionedioximes and their Pt(II) complexes: Synthesis and investigation of their antitumoral activities on breast cancer cells

Karahan, Emrah; Katmerlikaya, Tugba Gencoglu; Önal, Emel; Dag, Aydan; Gürek, Ayşe Gül; Ahsen, Vefa


MARC21 XML

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">New imidazolidindionedioximes and their Pt(II) complexes: Synthesis and investigation of their antitumoral activities on breast cancer cells</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.48623/aperta.273705</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
  <controlfield tag="001">273705</controlfield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">&lt;p&gt;Breast cancer is one of the most common types of cancer worldwide and has the most lethality ratio for females among all cancers. Although current cancer therapeutics have made considerable advancements, there is still room for improvement in terms of efficacy. Many anticancer drugs have a risk of causing serious adverse effects due to their non-specific cytotoxic effects on both tumor and healthy cells. New therapeutics might have a greater ability to kill cancer cells, reduce the volume of tumors, and improve overall therapy response rates. Herein, we report the efficient synthesis and characterization of three amphi &lt;em&gt;vic&lt;/em&gt;-dioximes and their six novel mono-, which are extremely rare in platinum chemistry, and bis- platinum(II) complexes for breast cancer treatment. Antitumoral activities of Pt(II) complexes have been investigated on CCD-1079Sk healthy fibroblast cell line, MCF-7 and MDA-MB-231 human breast cancer cell lines. Cytotoxicity, cell cycle, and apoptotic assays were performed. All new Pt(II) complexes exhibited selective antiproliferative effects on breast cancer cells by showing less cytotoxicity to healthy cells than known anticancer drugs Cisplatin and Bicalutamide. In vitro studies show that these new Pt complexes have high anticancer and antiproliferative effects and may be new alternatives to existing anticancer drugs.&lt;/p&gt;</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="2">opendefinition.org</subfield>
    <subfield code="a">cc-by</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="0">(orcid)0000-0003-3989-8711</subfield>
    <subfield code="u">Bezmialem Vakıf Üniversitesi</subfield>
    <subfield code="a">Katmerlikaya, Tugba Gencoglu</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="0">(orcid)0000-0001-7210-9126</subfield>
    <subfield code="u">Gebze Teknik Üniversitesi</subfield>
    <subfield code="a">Önal, Emel</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="0">(orcid)0000-0002-1552-8030</subfield>
    <subfield code="u">Bezmialem Vakıf Üniversitesi</subfield>
    <subfield code="a">Dag, Aydan</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="0">(orcid)0000-0002-8565-2424</subfield>
    <subfield code="u">Gebze Teknik Üniversitesi</subfield>
    <subfield code="a">Gürek, Ayşe Gül</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="0">(orcid)0000-0002-5366-8448</subfield>
    <subfield code="u">Gebze Teknik Üniversitesi</subfield>
    <subfield code="a">Ahsen, Vefa</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="b">article</subfield>
    <subfield code="a">publication</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="0">(orcid)0000-0002-5366-8448</subfield>
    <subfield code="u">Gebze Teknik Üniversitesi</subfield>
    <subfield code="a">Karahan, Emrah</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">imidazolidine</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">vic-dioxime</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">platinum complexes</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">breast cancer</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">cisplatin</subfield>
  </datafield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2024-06-13</subfield>
  </datafield>
  <controlfield tag="005">20240801202607.0</controlfield>
  <datafield tag="773" ind1=" " ind2=" ">
    <subfield code="n">doi</subfield>
    <subfield code="a">10.48623/aperta.273704</subfield>
    <subfield code="i">isVersionOf</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="o">oai:aperta.ulakbim.gov.tr:273705</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="z">md5:c7553c7dae15c8963c29d885fbc004e1</subfield>
    <subfield code="s">4123272</subfield>
    <subfield code="u">https://aperta.ulakbim.gov.trrecord/273705/files/TJC_Supplementary Information.pdf</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="u">http://www.opendefinition.org/licenses/cc-by-sa</subfield>
    <subfield code="a">Creative Commons Attribution Share-Alike</subfield>
  </datafield>
  <datafield tag="041" ind1=" " ind2=" ">
    <subfield code="a">eng</subfield>
  </datafield>
</record>
151
105
görüntülenme
indirilme
Tüm sürümler Bu sürüm
Görüntülenme 15183
İndirme 10554
Veri hacmi 432.8 MB222.7 MB
Tekil görüntülenme 11063
Tekil indirme 8950

Alıntı yap