Dergi makalesi Açık Erişim

New results on the melting thermodynamics of a circular DNA chain

2010    Kabakcioglu, A.; Orlandini, E.; Mukamel, D.

We investigate the impact of supercoil period and nonzero supercoil formation energy on the thermal denaturation of a circular DNA. Our analysis is based on a recently proposed generalization of the Poland Scheraga model that allows the DNA melting to be studied for plasmids with circular topology, where denaturation is accompanied by formation of supercoils. We find that the previously obtained first-order melting transition persists under the generalization discussed. The dependence of the size of the order-parameter jump at the transition point and the associated melting temperature are obtained analytically. (C) 2010 Elsevier B.V. All rights reserved.