2024-03-29T07:54:39Z
https://aperta.ulakbim.gov.tr/oai2d
oai:zenodo.org:37049
2021-03-15T19:44:03Z
user-tubitak-destekli-proje-yayinlari
Goker, Hakan
Alp, Mehmet
Ates-Alagoz, Zeynep
Yildiz, Sulhiye
2009-01-01
A series of 47 novel N(1)-alkylated-2-aryl-5(6)-substituted-1H-benzimidazoles and their three novel indole analogues were synthesized and evaluated for in vitro antifungal activities against Candida species by the tube dilution method. The results showed that compounds 79 and 80, having pyridine at the position C-2, of benzimidazoles exhibited the greatest activity with MIC values of 6.25-3.12 mu g/mL. Indole analogues 108-110 have no inhibitory activity.
https://aperta.ulakbim.gov.trrecord/37049
oai:zenodo.org:37049
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JOURNAL OF HETEROCYCLIC CHEMISTRY 46(5) 936-948
Synthesis and Potent Antifungal Activity Against Candida Species of Some Novel 1H-Benzimidazoles
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:76397
2021-03-16T04:38:39Z
user-tubitak-destekli-proje-yayinlari
Ezber, Yasemin
Sen, Omer Lutfi
Boybeyi, Zafer
Karaca, Mehmet
2015-01-01
This paper reports the second part of a study that aims to understand the thermally driven local flows and their interaction with each other over the province of Istanbul. The first part of the research evaluates a series of sensitivity simulations involving perturbations to the landscape. The present one includes an analysis of the real case simulations with an evaluation of the model performance. The second part also uses the same meso-scale model (OMEGA) with the same model configuration as in the first part. The model is able to reproduce the large-scale fields. Comparison of model-estimated fields with the radiosonde measurements over Istanbul also yields satisfactory results. The model is also able to capture the diurnal change of surface meteorological parameters such as temperature and wind speed, but there are over-and underestimations. The real case simulations indicate a clear cycle of land and sea breeze circulations in both summer and winter. In agreement with the sensitivity cases, a convergence zone occurs over the province due to the merge of two sea breezes in both seasons. In summer case, the convergence takes place at 1100 LST, and in winter case, it occurs at 1500 LST. Development of a channeled flow along the Bosphorus is also observed in the real case simulations. Return flows are observed above 1 km height during the summer case and above 300m height during the winter case. The northerly flow induced by the urban heat island effect prevents the inland penetration of the southerly sea breeze over the province. Thus, the northerly sea breeze moves faster, surmounts the southerly one over the south of the province, where the urban area is located, and dominates the airflow over Istanbul, especially in the afternoon.
https://aperta.ulakbim.gov.trrecord/76397
oai:zenodo.org:76397
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INTERNATIONAL JOURNAL OF CLIMATOLOGY 35(15) 4802-4828
Investigation of local flow features in Istanbul. Part II: high-resolution real case simulations
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:17855
2021-03-15T10:00:15Z
user-tubitak-destekli-proje-yayinlari
Durust, Yasar
Sagirli, Akin
Fronczek, Frank R.
2011-01-01
In the title molecule, C24H18N2O3S, the 13-atom ring system comprising the quinoxaline and fused five-membered ring exhibits an r.m.s. deviation from coplanarity of 0.039 angstrom, with a maximum deviation of 0.0710 (10) angstrom for the PhCO-bearing C atom of the five-membered ring. The 10-membered C8N2 quinoxaline ring system has an r.m.s. deviation from coplanarity of 0.022 angstrom, with a maximum deviation of 0.0403 (9) angstrom for the C atom involved in the C=C bond in the five-membered ring. The three atoms of the five-membered ring fused to the quinoxaline ring system show deviations of up to 0.118 (2) angstrom for the PhCO-bearing C atom. C-N bond distances in the quinoxaline ring system of the title molecule deviate from those in unsubstituted quinoxaline. In particular, the two C-N distances to the N atom involved in the five-membered ring are essentially equal, with values of 1.3786 (17) and 1.3773 (16) angstrom, unlike the difference of nearly 0.06 angstrom in quinoxaline.
https://aperta.ulakbim.gov.trrecord/17855
oai:zenodo.org:17855
info:eu-repo/semantics/openAccess
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ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS 67 O2859-+
(Phenyl)(3-phenylsulfonyl-1,2-dihydropyrrolo[1,2-a]quinoxalin-1-yl)methanone
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:37019
2021-03-15T19:43:38Z
user-tubitak-destekli-proje-yayinlari
Meidl, Wilfried
Oezbudak, Ferruh
2008-01-01
The joint linear complexity of multisequences is an important security measure for vectorized stream cipher systems. Extensive research has been carried out on the joint linear complexity of N-periodic multisequences using tools from Discrete Fourier transform. Each N-periodic multisequence can be identified with a single N-periodic sequence over an appropriate extension field. It has been demonstrated that the linear complexity of this sequence, the so called generalized joint linear complexity of the multisequence, may be considerably smaller than the joint linear complexity, which is not desirable for vectorized stream ciphers. Recently new methods have been developed and results of greater generality on the joint linear complexity of multisequences consisting of linear recurring sequences have been obtained. In this paper, using these new methods, we investigate the relations between the generalized joint linear complexity and the joint linear complexity of multisequences consisting of linear recurring sequences.
https://aperta.ulakbim.gov.trrecord/37019
oai:zenodo.org:37019
info:eu-repo/semantics/openAccess
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Generalized Joint Linear Complexity of Linear Recurring Multisequences
info:eu-repo/semantics/conferencePaper
publication-conferencepaper
oai:zenodo.org:61253
2021-03-16T01:10:52Z
user-tubitak-destekli-proje-yayinlari
Aydemir, Onder
Kayikcioglu, Temel
2014-01-01
Background: Input signals of an EEG based brain computer interface (BCI) system are naturally non-stationary, have poor signal to noise ratio, depend on physical or mental tasks and are contaminated with various artifacts such as external electromagnetic waves, electromyogram and electrooculogram. All these disadvantages have motivated researchers to substantially improve speed and accuracy of all components of the communication system between brain and a BCI output device.
https://aperta.ulakbim.gov.trrecord/61253
oai:zenodo.org:61253
info:eu-repo/semantics/openAccess
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JOURNAL OF NEUROSCIENCE METHODS 229 68-75
Decision tree structure based classification of EEG signals recorded during two dimensional cursor movement imagery
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:17833
2021-03-15T09:59:58Z
user-tubitak-destekli-proje-yayinlari
Sankir, Nurdan Demirci
Tezel, Tamer
Dogan, Bahadir
2011-01-01
Nanocrystalline CdS thin films have been successfully deposited on mechanically flexible polyethylene terephthalate substrates via electrodeposition technique. Structural and optical properties of as-deposited and CuCl2 treated CdS thin films have been investigated using X-ray diffraction, UV-vis spectrophotometry and X-ray photoelectron spectroscopy. Both as-deposited and CuCl2-treated CdS samples have been integrated into photoelectrochemical solar cell. It has been observed that power conversion efficiency of thin films increased dramatically and reached approximately 2% after CuCl2-treatment. Electrochemical impedance spectroscopy has been used to investigate the charge transfer mechanism. Frequency dependent measurements indicated that it was possible to fit almost all as-deposited samples into one time constant model. On the other hand, mixed kinetic and diffusion model can be used to identify the charge transfer mechanism of CuCl2-treated samples.
https://aperta.ulakbim.gov.trrecord/17833
oai:zenodo.org:17833
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ENERGY EDUCATION SCIENCE AND TECHNOLOGY PART A-ENERGY SCIENCE AND RESEARCH 27(1) 63-78
Flexible CdS photoelectrodes for photoelectrochemical solar cell applications
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:233244
2022-10-07T08:39:13Z
user-tubitak-destekli-proje-yayinlari
Uzal, Hasan
Doner, Ali
Bayrakceken, Huseyin
2022-01-01
Hydrogen production via water splitting is a very attractive way using effective electrocatalysts. One of the effective electrocatalysts that are used in water splitting is NiCo alloys. In this study, highly ordered titanium dioxide nanotubes (TiO2-NTs) are firstly prepared by electrochemical anodization method in terms of being a substrate material for NiCo coatings. Hydrogen evolution behaviors of three types of NiCo coated TiO2-NTs are investigated in 1 M KOH solution at room temperature. Coated surfaces are characterized by scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy, X-ray diffraction (XRD), and cyclic voltammetry (CV). HER activities of NiCo coated TiO2-NTs are investigated by cathodic current-potential curves, electrochemical impedance spectroscopy (EIS), and electrolysis process. The stability of NiCo-coated TiO2-NTs is also investigated. Results show that TiO2-NTs surface leads to large surface area and high porosity for NiCo nano-particles and thus, HER performance of coatings increases. NiCo-coated TiO2-NTs improves the catalytic HER activity in terms of current density, hydrogen volume, polarization resistance (R-p), and conductivity. Enhanced HER activity can be based on the boosted surface area, conductivity, and more active sites for hydrogen ion adsorption as well as synergistic effects.
https://aperta.ulakbim.gov.trrecord/233244
oai:aperta.ulakbim.gov.tr:233244
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ENERGY SOURCES PART A-RECOVERY UTILIZATION AND ENVIRONMENTAL EFFECTS 44(2) 3406-3417
Preparation and fabrication of NiCo coated TiO2-NTs for hydrogen evolution
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:52893
2021-03-15T23:16:23Z
user-tubitak-destekli-proje-yayinlari
Bilge, Gonca
Sezer, Banu
Eseller, Kemal Efe
Berberoglu, Halil
Topcu, Ali
Boyaci, Ismail Hakki
2016-01-01
A rapid and in situ method has been developed to detect and quantify adulterated milk powder through adding whey powder by using laser induced breakdown spectroscopy (LIBS). The methodology is based on elemental composition differences between milk and whey products. Milk powder, sweet and acid whey powders were produced as standard samples, and milk powder was adulterated with whey powders. Based on LIBS spectra of standard samples and commercial products, species was identified using principle component analysis (PCA) method, and discrimination rate of milk and whey powders was found as 80.5%. Calibration curves were obtained with partial least squares regression (PLS). Correlation coefficient (R-2) and limit of detection (LOD) values were 0.981 and 1.55% for adulteration with sweet whey powder, and 0.985 and 0.55% for adulteration with acid whey powder, respectively. The results were found to be consistent with the data from inductively coupled plasma-mass spectrometer (ICP-MS) method. (C) 2016 Elsevier Ltd. All rights reserved.
https://aperta.ulakbim.gov.trrecord/52893
oai:zenodo.org:52893
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FOOD CHEMISTRY 212 183-188
Determination of whey adulteration in milk powder by using laser induced breakdown spectroscopy
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:17843
2021-03-15T10:00:06Z
user-tubitak-destekli-proje-yayinlari
Gumen, A.
Keskin, A.
Yilmazbas-Mecitoglu, G.
Karakaya, E.
Wiltbank, M. C.
2011-01-01
Dry period and early post-partum management are decisive factors for fertility in lactating dairy cows. Previous studies have shown that decreased dry matter intake (DMI) and increased non-esterified fatty acids (NEFA) negatively affect fertility and subsequent milk production. The traditional dry period decreases DMI prior to parturition, resulting in a decrease in energy intake. A negative energy balance increases NEFA concentration, and increased NEFA may impair the immune system, especially by decreasing neutrophil function prior to parturition. Earlier studies have shown that postpartum health disorders, including retained placenta and metritis, were correlated with periparturient neutrophil function. In addition, decreased DMI is also linked to a reduced body condition score (BCS) in dairy cows. These events in the periparturient period negatively affect fertility. Some manipulation, such as shortening the dry period, may be a solution to increased DMI in the periparturient period, preventing postpartum disorders and subsequent fertility issues. This article aims to explain the effects of shortening the dry period on reproduction and early post-partum treatments to improve fertility. In addition, timed artificial insemination protocols will be discussed for use during the post-partum period to improve fertility in dairy cows.
https://aperta.ulakbim.gov.trrecord/17843
oai:zenodo.org:17843
info:eu-repo/semantics/openAccess
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REPRODUCTION IN DOMESTIC ANIMALS 46 11-17
Dry Period Management and Optimization of Post-Partum Reproductive Management in Dairy Cattle
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:261997
2023-07-29T15:39:26Z
user-tubitak-destekli-proje-yayinlari
Cekyay, Bora
Ozekici, Suleyman
2023-01-01
We analyze mean time to failure and availability of systems that perform semi-Markov missions. The mission process is the minimal semi-Markov process associated with a Markov renewal process. Therefore, the successive phases of the mission follow a Markov chain, and the phase durations are generally distributed. The lifetimes of the non-identical components in the system are assumed to be generally distributed and are modeled using intrinsic aging concepts. Moreover, the lifetime parameters of the components and the configuration of the system change depending on the phases of the mission. We characterize the mean time to failure through solving a Poisson equation, and we analyze the system availability assuming that repair duration has a general distribution which is dependent on the phase of the mission during which the failure has occurred and on the deterioration level of the system.
https://aperta.ulakbim.gov.trrecord/261997
oai:aperta.ulakbim.gov.tr:261997
info:eu-repo/semantics/openAccess
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STOCHASTIC MODELS 39(2) 414-447
MTTF and availability of semi-Markov missions with non-identical generally distributed component lifetimes
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:37135
2021-03-15T19:45:12Z
user-tubitak-destekli-proje-yayinlari
Cadirli, E.
Boyuk, U.
Engin, S.
Kaya, H.
Marasli, N.
2009-01-01
Sn-1.2wt.%Cu eutectic alloy was directionally solidified upward with different growth rates (2-78-136.36 mu m s(-1)) at a constant temperature gradient (2.69 K mm(-1)) and with different temperature gradients (2.69-8.88 K mm(-1)) at a constant growth rate (6.80 mu m s(-1)) in the Bridgman-type growth apparatus. The measurements of microhardness of directionally solidified samples were obtained by using a microhardness test device. The dependence of microhardness HV on the growth rate (V) and temperature gradient (G) were analysed. According to these results, it has been found that with the increasing values of V and G, the values of HV increase. Variations of electrical resistivity (p) and electrical conductivity (a) for Sn-1.2wt.%Cu cast alloy with the temperature in the range of 300-500 K were also measured by using a standard d.c. four-point probe technique. The variation of Lorenz coefficient with the temperature for Sn-1.2wt.%Cu eutectic alloy was determined by using the measured values of electrical conductivity and thermal conductivity. The enthalpy of fusion for the same alloy was determined by means of differential scanning calorimeter (DSC) from heating trace during the transformation from eutectic liquid to eutectic solid.
https://aperta.ulakbim.gov.trrecord/37135
oai:zenodo.org:37135
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KOVOVE MATERIALY-METALLIC MATERIALS 47(6) 381-387
Variations of microhardness with the solidification processing parameters and thermo-electrical properties with the temperature in the Sn-Cu alloy
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:61221
2021-03-16T01:10:27Z
user-tubitak-destekli-proje-yayinlari
Yarali, Engin
Yilmaz, Onur
Cemal, Ibrahim
Karaca, Orhan
Taskin, Turgay
2014-01-01
Esme District in Usak Province has a special role in western Anatolia sheep husbandry due to its number of animals and large pastures. A genotype with the characteristics of the Kivircik breed has emerged and became common in the region in the last 20-30 years. This study aimed to determine the meat quality characteristics of Kivricik lambs reared in the locality, which has a large market share. The study determined parameters about water and cooking loss and shear force in M. longissimus dorsi, M. longissimus thoracis, and M. semitendinosus muscles taken from the left half of lamb carcasses. Furthermore, meat quality characteristics such as pH, color, and fatty acid composition characteristics in the M. longissimus dorsi muscle were determined. In conclusion, the low shear force values (mean 2.27) obtained from Kivircik meat showed that it was tender. This result is consistent with the high demand from consumers for the meat of this breed.
https://aperta.ulakbim.gov.trrecord/61221
oai:zenodo.org:61221
info:eu-repo/semantics/openAccess
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TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES 38(4) 452-458
Meat quality characteristics in Kivircik lambs
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:259721
2023-07-29T10:02:20Z
user-tubitak-destekli-proje-yayinlari
Serdaroglu, Goncagul
Uludag, Nesimi
Colak, Naki
Rajkumar, Parthasarathi
2023-01-01
A novel nitro containing thiophene derivatives containing have been synthesized. In pharmaceutical chemistry, thiophene derivatives show a biological effect. Due to the promising antimicrobial, analgesic and anti-inflammatory, and antitumor activity, alternative and different approaches have also been one of the main objectives in the field of chemical sciences. Based on the broad range of biological properties of thiophene derivatives, this study aimed to evaluate the antioxidant activity of novel thiophene derivatives and explore the electrochemical features using CV (cyclic voltammetry). The synthesis and characteriza-tion of novel benzo[b]thiophone derivatives were confirmed using spectroscopic methods with 1H-NMR, 13C-NMR, FT-IR, and UV-vis. The DFT and TD-DFT computations were conducted to compare the spectro-scopic data and then confirm the molecular structures of the compounds 1-3 . The FMO and NBO analy-ses were conducted to estimate the possible reactivity features and key intra-molecular interactions. Last, molecular docking investigations were performed to explore the possible interaction of each compound to human EGFR Kinase.(c) 2022 Elsevier B.V. All rights reserved.
https://aperta.ulakbim.gov.trrecord/259721
oai:aperta.ulakbim.gov.tr:259721
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JOURNAL OF MOLECULAR STRUCTURE 1271
Nitrobenzamido substitution on thiophene-3-carboxylate: Electrochemical investigation, antioxidant activity, molecular docking, DFT calculations
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:76243
2021-03-16T04:36:32Z
user-tubitak-destekli-proje-yayinlari
Parlakkilic, Alaattin
2015-01-01
Generally it is not easy for an instructor to prepare and deliver electronic courses via e-learning. Therefore it is necessary to work and develop an easy system. In this context module technology was used to for provide modularity in conducting educational development of e-learning course. Then, rapid e-learning was used for more quick and easy course development. In order to implement modular rapid e-learning, a desktop virtual environment was set up. Modular rapid e-learning was used by teachers and students in a one semester course and student success and reactions were evaluated. And also the overall hybrid system cost was calculated and reported. In implementation we combined modular course design with rapid e-learning and desktop virtualization in education of 3rd year nursing students for a one semester course. The effectiveness of this hybrid method was evaluated with respect to students' success, students' opinions and over all cost effectiveness. It was seen that the hybrid method was educationally more effective than traditional method comparing with previous year students' success and fit with students' requirements. The cost reduction was %41 comparing with traditional desktop and e-learning system.
https://aperta.ulakbim.gov.trrecord/76243
oai:zenodo.org:76243
info:eu-repo/semantics/openAccess
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TURKISH ONLINE JOURNAL OF DISTANCE EDUCATION 16(1) 3-18
MODULAR RAPID E-LEARNING FRAMEWORK (MORELF) IN DESKTOP VIRTUALIZATION ENVIRONMENT: An Effective Hybrid Implementation in Nurse Education
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:230034
2022-10-07T07:47:41Z
user-tubitak-destekli-proje-yayinlari
Seyedi-Viand, Seyed Mohsen
Eseller-Bayat, E. Ece
2022-01-01
The liquefaction or softening of the soils and the potential vulnerability of existing buildings on liquefiable soils continue to be of major concern to the public because it has repeatedly caused severe damages to buildings during strong earthquakes, such as 1967 Niigata (Japan), 1999 Adapazari (Turkey), 2010 Maule (Chile), 2011 Christchurch (New Zealand) and 2011 Great East (Japan) earthquakes. Studies on liquefaction have been devoted to realizing the mechanism of liquefaction of fully saturated sands and developing liquefaction mitigation techniques during the last decades. In recent years, some researchers have discovered liquefaction mitigation procedures that are different from conventional techniques. They investigated techniques that involve a reduction in the degree of saturation and the creation of partially saturated zones in the liquefiable soil deposits. Since these techniques are relatively new and their efficiency and applicability to tackle the liquefaction in real projects is still being studied, the existence of a comprehensive literature review seems to be of interest for researchers to shed light on future studies. This literature review intends to present an abstract of the experimental and numerical studies on the liquefaction resistance of sands partially saturated as a liquefaction countermeasure. Also, noteworthy outcomes of the presented studies are presented here, chronologically ordered, in tables.
https://aperta.ulakbim.gov.trrecord/230034
oai:aperta.ulakbim.gov.tr:230034
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GEOTECHNICAL AND GEOLOGICAL ENGINEERING 40(2) 499-530
Partial Saturation as a Liquefaction Countermeasure: A Review
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:52899
2021-03-15T23:16:28Z
user-tubitak-destekli-proje-yayinlari
Boyaci, Arman
Ekim, Tinaz
Shalom, Mordechai
Zaks, Shmuel
2016-01-01
The families of Edge Intersection Graphs of Paths in a tree (resp. in a grid) EPT (resp. EPG) are well studied graph classes. Recently we introduced the class of graphs of Edge Intersecting and Non-Splitting Paths in a Tree (ENPT) [5]. In this model, two vertices are adjacent if they represent two intersecting paths of a tree whose union is also a path. In this study we generalize this graph class by allowing the host graph to be an arbitrary graph. These are the graphs of Edge-Intersecting and Non-Splitting Paths ENP. Although the Edge Intersection Graphs of Paths in an arbitrary graph includes all graphs, we show that this is not the case for ENP. We also show that the class ENP coincides with the family of graphs of Edge-Intersecting and Non-Splitting Paths in a Grid (ENPG). Following similar studies for EPG graph class, we study the implications of restricting the number of bends of the individual paths in the grid. We show that such a restriction restricts the graph class. Specifically, by restricting the number of bends one gets an infinite sequence of classes such that every class is properly included in the next one. (C) 2015 Elsevier B.V. All rights reserved.
https://aperta.ulakbim.gov.trrecord/52899
oai:zenodo.org:52899
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THEORETICAL COMPUTER SCIENCE 629 40-50
Graphs of edge-intersecting and non-splitting paths
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:83473
2021-03-16T06:15:15Z
user-tubitak-destekli-proje-yayinlari
Akal, Cuneyt
Candan, Osman
Koralay, O. Ersin
Oberhaensli, Roland
Chen, Fukun
Prelevic, Dejan
2012-01-01
Afyon Zone, which was derived from the Anatolide-Tauride platform during closure of the Neo-Tethys, is made up of pre-Mesozoic basement and unconformably overlying Triassic-Early Tertiary cover series. The Afyon Zone contains widespread metavolcanic rocks, which are dominated by rhyolite, dacite, and trachyandesite. They form a distinct volcanic succession, which is separated from the underlying Silurian-Lower Carboniferous metacarbonates and meta-siliciclastics by a regional unconformity. Trachyandesitic metavolcanics are made up of massive lava flows, pyroclastics and epiclastics, less frequently, domes and dikes, which were developed on a deeply eroded subaerial landmass. U/Pb and Pb/Pb zircon geochronology yielded Lower Triassic (similar to 250 Ma) ages, which are interpreted as extrusion age of trachyandesitic volcanics. Based on the stratigraphic, geochronological, and geochemical data, we suggest that these Lower Triassic magmatic rocks represent an extensional tectonic setting on the northern active margin of the Gondwana, which led to the development of the northern branch of the Neo-Tethys.
https://aperta.ulakbim.gov.trrecord/83473
oai:zenodo.org:83473
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INTERNATIONAL JOURNAL OF EARTH SCIENCES 101(1) 177-194
Early Triassic potassic volcanism in the Afyon Zone of the Anatolides/Turkey: implications for the rifting of the Neo-Tethys
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:3793
2021-03-15T05:50:25Z
user-tubitak-destekli-proje-yayinlari
Zheng, X.
Zhang, L.
Kuang, Y.
Venkataramani, V.
Jin, F.
Hein, K.
Zafeiriou, M. P.
Lenz, C.
Moebius, W.
Kilic, E.
Hermann, D. M.
Weber, M. S.
Urlaub, H.
Zimmermann, W. -H.
Baehr, M.
Doeppner, Thorsten R.
2021-01-01
Stem cells such as mesenchymal stem cells (MSCs) enhance neurological recovery in preclinical stroke models by secreting extracellular vesicles (EVs). Since previous reports have focused on the application of MSC-EVs only, the role of the most suitable host cell for EV enrichment and preclinical stroke treatment remains elusive. The present study aimed to evaluate the therapeutic potential of EVs derived from neural progenitor cells (NPCs) following experimental stroke. Using the PEG technique, EVs were enriched and characterized by electron microscopy, proteomics, rt-PCR, nanosight tracking analysis, and Western blotting. Different dosages of NPC-EVs displaying a characteristic profile in size, shape, cargo protein, and non-coding RNA contents were incubated in the presence of cerebral organoids exposed to oxygen-glucose deprivation (OGD), significantly reducing cell injury when compared with control organoids. Systemic administration of NPC-EVs in male C57BL6 mice following experimental ischemia enhanced neurological recovery and neuroregeneration for as long as 3 months. Interestingly, the therapeutic impact of such NPC-EVs was found to be not inferior to MSC-EVs. Flow cytometric analyses of blood and brain samples 7 days post-stroke demonstrated increased blood concentrations of B and T lymphocytes after NPC-EV delivery, without affecting cerebral cell counts. Likewise, a biodistribution analysis after systemic delivery of NPC-EVs revealed the majority of NPC-EVs to be found in extracranial organs such as the liver and the lung. This proof-of-concept study supports the idea of EVs being a general concept of stem cell-induced neuroprotection under stroke conditions, where EVs contribute to reverting the peripheral post-stroke immunosuppression.
https://aperta.ulakbim.gov.trrecord/3793
oai:zenodo.org:3793
info:eu-repo/semantics/openAccess
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TRANSLATIONAL STROKE RESEARCH 12(1) 185-203
Extracellular Vesicles Derived from Neural Progenitor Cells--a Preclinical Evaluation for Stroke Treatment in Mice
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:37023
2021-03-15T19:43:42Z
user-tubitak-destekli-proje-yayinlari
Bahcecioglu, Z.
Berndt, R.
Kabaktepe, S.
2009-01-01
Bahcecioglu Z., Berndt R. & Kabaktepe S. (2009) Puccinia ardahanensis sp. nov., a new rust fungus from Turkey, - Sydowia 61 (2): 209-213.
https://aperta.ulakbim.gov.trrecord/37023
oai:zenodo.org:37023
info:eu-repo/semantics/openAccess
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SYDOWIA 61(2) 209-213
Puccinia ardahanensis sp nov., a new rust fungus from Turkey
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:17863
2021-03-15T10:00:21Z
user-tubitak-destekli-proje-yayinlari
Dikbas, Neslihan
Dadasoglu, Fatih
Kotan, Recep
Cakir, Ahmet
2011-01-01
The essential oil isolated from the aerial parts of wild Turkish Satureja hortensis L. (summer savory) was analyzed by GC-MS, and carvacrol (54.7 %), gamma-terpinene (20.9 %), p-cymene (12.3 %), alpha-terpinene (2.0 %), and thymol (2.0 %) were found to be major components of the oil. Post-harvest decay of fruits caused by some fungi is still a most important problem and causes major crop losses during storage and shipment. High relative humidity during storage and marketing conditions accelerate development of fungal disease and decay of the grapes. The six different concentrations of the oil (0.01, 0.02, 0.04, 0.11, 0.22 and 0.45 mu L/cm(3)) were tested for their effectiveness in reducing decay of strawberry and grape fruits at three storage temperature (5, 10 and 20 degrees C). The oil tested reduced decay of strawberry and grape fruits compared to controls, in particularly at low temperatures (5 and 10 degrees C). Decay reducing effect of the oil on strawberry and grape fruits increased with increase in doses of the oil. However, microbial development in the fruits increased with increase in temperature. Nevertheless, the present results showed that S. hortensis essential oil has a significant reducing effect on the decay of strawberry and grape fruits during storage at low temperatures. Therefore, the essential oil of summer savory may be a potential source of alternative fungicides to protect strawberry and grape fruits as well as other stored products from pathogens and saprophytes.
https://aperta.ulakbim.gov.trrecord/17863
oai:zenodo.org:17863
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JOURNAL OF ESSENTIAL OIL BEARING PLANTS 14(2) 151-160
Influence of Summer Savory Essential Oil (Satureja hortensis) on Decay of Strawberry and Grape
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:83429
2021-03-16T06:14:36Z
user-tubitak-destekli-proje-yayinlari
Bojanowska-Czajka, Anna
Torun, Murat
Kciuk, Gabriel
Wachowicz, Mariusz
Ozbay, Dilek Solpan
Guven, Olgun
Bobrowski, Krzysztof
Trojanowicz, Marek
2012-01-01
The decomposition of the widely used organophosphorus pesticide parathion was carried out in aqueous solutions by the use of gamma-irradiation from a Co-60 source or ozonation by means of an ozone generator, and by combined processes of ozonation and radiolysis. Factors affecting the parathion decomposition as well formation and decomposition of the main by-products, including irradiation dose, length of ozonation time, and presence of common scavengers, were investigated. The most efficient was found to be the gamma-irradiation process combined with a short ozonation period; about 1 kGy irradiation dose was sufficient to decompose the pesticide in 15 mg/L solutions. Chemical studies of the decomposition of parathion were accompanied by monitoring of toxicity changes of irradiated solutions with the Microtox test.
https://aperta.ulakbim.gov.trrecord/83429
oai:zenodo.org:83429
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JOURNAL OF AOAC INTERNATIONAL 95(5) 1378-1385
Analytical and Toxicological Studies of Decomposition of Insecticide Parathion after Gamma-Irradiation and Ozonation
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:52947
2021-03-15T23:17:06Z
user-tubitak-destekli-proje-yayinlari
Aydin, Muhammet
Gorur, Mesut
Yilmaz, Faruk
2016-01-01
A new hexa-armed star polymer bearing 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-pending polymer chains emanating from a phosphazene core (P2) was prepared and used as the cathode material in Li-ion battery assembly. The properties of the assembled battery (BP2) were compared with those of BL2 assembled using its linear counterpart (L2). Their spin concentrations investigated via solution electron spin resonance (ESR) measurements were found to be almost the same. The charge/discharge capacities and energy densities of BP2 were considerably higher than those of BL2. However, they exhibited comparable charge/discharge efficiencies and their discharge capacities dropped to similar percentages of their initial values. (C) 2016 Elsevier B.V. All rights reserved.
https://aperta.ulakbim.gov.trrecord/52947
oai:zenodo.org:52947
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REACTIVE & FUNCTIONAL POLYMERS 102 11-19
Phosphazene-cored star polymer bearing redox-active side groups as a cathode-active material in Li-ion batteries
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:236072
2022-10-07T09:34:26Z
user-tubitak-destekli-proje-yayinlari
Uncu, Oguz
Ozen, Banu
2022-01-01
Minor components of olive oils can be good markers for their authenticity, which is a significant quality issue for this product. It was aimed to determine individual and total fatty acid alkyl esters and waxes as minor constituents of olive oil and to investigate their novel varietal authentication capability separately and in combination for three main olive cultivars grown in three distinct locations of Aegean Region of Turkey. In addition, basic quality and purity parameters as free fatty acid, K values and fatty acid profiles were also determined for the characterization of the samples. Olive oil samples from different cultivars had different fatty acid profiles and two of these varieties had similar quality parameters. Statistical analyses were conducted with orthogonal partial least squares discriminant analysis (OPLS-DA) to differentiate varieties with respect to their individual and combined parameters of fatty acid alkyl esters and waxes. For calibration sets, use of individual fatty acid alkyl esters profile resulted in 80% correct classification rate while waxes alone was 67% successful in classifying the olive oils according to variety. It was found that alkyl esters in combination with waxes were more effective in discrimination of olive oils with respect to cultivar compared to their individual forms and the correct classification rate for the generated model is 92% for calibration set. Since fatty acid alkyl esters along with waxes have effect on cultivar differentiation, they could have a potential as authentication tools for olive oil besides their known quality characteristics.
https://aperta.ulakbim.gov.trrecord/236072
oai:aperta.ulakbim.gov.tr:236072
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JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION 16(1) 561-569
Fatty acid alkyl ester and wax compositions of olive oils as varietal authentication indicators
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:4293
2021-03-15T05:57:07Z
user-tubitak-destekli-proje-yayinlari
Sarigil, Oyku
Anil-Inevi, Muge
Firatligil-Yildirir, Burcu
Unal, Yagmur Ceren
Yalcin-Ozuysal, Ozden
Mese, Gulistan
Tekin, H. Cumhur
Ozcivici, Engin
2021-01-01
Tissue engineering research aims to repair the form and/or function of impaired tissues. Tissue engineering studies mostly rely on scaffold-based techniques. However, these techniques have certain challenges, such as the selection of proper scaffold material, including mechanical properties, sterilization, and fabrication processes. As an alternative, we propose a novel scaffold-free adipose tissue biofabrication technique based on magnetic levitation. In this study, a label-free magnetic levitation technique was used to form three-dimensional (3D) scaffold-free adipocyte structures with various fabrication strategies in a microcapillary-based setup. Adipogenic-differentiated 7F2 cells and growth D1 ORL UVA stem cells were used as model cells. The morphological properties of the 3D structures of single and cocultured cells were analyzed. The developed procedure leads to the formation of different patterns of single and cocultured adipocytes without a scaffold. Our results indicated that adipocytes formed loose structures while growth cells were tightly packed during 3D culture in the magnetic levitation platform. This system has potential for ex vivo modeling of adipose tissue for drug testing and transplantation applications for cell therapy in soft tissue damage. Also, it will be possible to extend this technique to other cell and tissue types.
https://aperta.ulakbim.gov.trrecord/4293
oai:zenodo.org:4293
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BIOTECHNOLOGY AND BIOENGINEERING 118(3) 1127-1140
Scaffold-free biofabrication of adipocyte structures with magnetic levitation
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:2857
2021-03-15T05:38:06Z
user-tubitak-destekli-proje-yayinlari
Yoney, Ferhat
2020-01-01
Open Theist theologians argue that their view of divine foreknowledge and providence is the correct interpretation of the Bible, and suggest some biblical evidence to support this claim. Among these theologians, Gregory A. Boyd's case is the most systematic, and also the most comprehensive and rigorous. Taking into consideration (1) the main philosophical claims of Open Theism and its main rivals, namely Calvinism and Molinism, and (2) Open Theist theologians' interpretative principles for the Bible, the biblical evidence for Open Theism suggested by Boyd can be classified into three groups according to their strength. I will argue that the first group of themes has no evidential value for Open Theism, since these themes can be interpreted just as plausibly from a Calvinist or Molinist perspective. By contrast, the second group of themes has some evidential value and thus constitutes prima facie evidence for Open Theism, since these themes make most sense under an Open Theist interpretation. However, these themes also make some sense on a Molinist reading. The third group of themes, I argue, has most evidential value for Open Theism, since it seems hard to reconcile these themes either with Calvinism or Molinism.
https://aperta.ulakbim.gov.trrecord/2857
oai:zenodo.org:2857
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HEYTHROP JOURNAL 61(2) 253-266
An Examination of the Biblical Evidence for Open Theism
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:17787
2021-03-19T09:19:11Z
user-tubitak-destekli-proje-yayinlari
user-truba-turkiye
Erdogan, Rezan
Fellah, Mehmet Ferdi
Onal, Isik
2011-01-01
Density functional theory (DFT) calculations performed at ONIOM DFT B3LYP/6-31G**-MD/UFF level are employed to study molecular and dissociative water adsorption on rutile TiO2 (110) surface represented by partially relaxed Ti25O37 ONIOM cluster. DFT calculations indicate that dissociative water adsorption is not favorable because of high activation barrier (23.2 kcal/mol). The adsorption energy and vibration frequency of both molecularly and dissociatively adsorbed water molecule on rutile TiO2 (110) surface compare well with the values reported in the literature. (C) 2009 Wiley Periodicals, Inc. Int J Quantum Chem 111: 174-181, 2011
https://aperta.ulakbim.gov.trrecord/17787
oai:zenodo.org:17787
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INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY 111(1) 174-181
An ONIOM and DFT Study of Water Adsorption on Rutile TiO2 (110) Cluster
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:83469
2021-03-16T06:15:12Z
user-tubitak-destekli-proje-yayinlari
Fentoglu, O.
Kirzioglu, F. Y.
Ozdem, M.
Kocak, H.
Sutcu, R.
Sert, T.
2012-01-01
OBJECTIVE: The aim of this study was to evaluate the effects of periodontal treatment on serum and gingival crevicular fluid (GCF) proinflammatory cytokine levels in hyperlipidemic patients with periodontitis. MATERIALS AND METHODS: Fifty-two patients with hyperlipidemia and periodontitis and 28 systemically healthy controls with periodontitis (C) were included in the study. Hyperlipidemic groups were divided into two groups as suggested diet (HD) and prescribed statin (HS). The clinical periodontal parameters, fasting venous blood, and GCF samples were obtained, and serum tumor necrosis factor-alpha (TNF-a), interleukin (IL) 1-beta, and IL-6 levels were evaluated at baseline and at 3 months follow-up (3MFU) after the completion of the non-surgical periodontal treatment that included scaling and root planning. RESULTS: Percentage of bleeding on probing was significantly higher in the HS group than both the HD and C groups. In the HD and HS groups, there were significant decreases in serum IL-6 andGCFTNF-a levels between the 3MFUand baseline. Asignificant decrease was also found in GCF IL-6 at the end of the study period in the HS group. CONCLUSION: The combination of the periodontal therapy and antilipemic treatment may provide beneficial effects on the metabolic and inflammatory control of hyperlipidemia. Oral Diseases (2012) 18, 299-306
https://aperta.ulakbim.gov.trrecord/83469
oai:zenodo.org:83469
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ORAL DISEASES 18(3) 299-306
Proinflammatory cytokine levels in hyperlipidemic patients with periodontitis after periodontal treatment
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:137629
2021-04-27T10:47:17Z
user-tubitak-destekli-proje-yayinlari
Sahin, S.
Sastry, S. K.
Bayindirli, L.
1999-01-01
The effective thermal conductivities of potato were measured at various stages of the frying process. Samples were taken at 30 s intervals during frying, and two different methods (line heat source and modified Fitch method) were used to measure the effective thermal conductivity. An iterative Kopelman model was used for the prediction of thermal properties. The effective thermal conductivity decreased as frying time increased. The variation of experimental measurements by both methods and modeling were within 10% over most of the range studied. The probe method yielded values that were not significantly different than the modified Fitch method. Lower standard deviations were obtained with the modified Fitch method.
https://aperta.ulakbim.gov.trrecord/137629
oai:zenodo.org:137629
info:eu-repo/semantics/openAccess
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INTERNATIONAL JOURNAL OF FOOD PROPERTIES 2(2) 151-161
EFFECTIVE THERMAL CONDUCTIVITY OF POTATO DURING FRYING: MEASUREMENT AND MODELING
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:61177
2021-03-16T01:09:48Z
user-tubitak-destekli-proje-yayinlari
Ozelci, E.
Aas, M.
Jonas, A.
Kiraz, A.
2014-01-01
We demonstrate optofluidic microlasers using highly efficient non-radiative Forster resonance energy transfer (FRET) for pumping of gain medium placed within liquid microdroplets situated on a superhydrophobic surface. Microdroplets generated from a mixture of ethylene glycol, glycerol, and water and stained with the FRET donor-acceptor dye pair Rhodamine 6G-Rhodamine 700 serve as active optical resonant cavities hosting high-quality whispering gallery modes. Upon direct optical pumping of the donor with a pulsed laser, lasing is observed in the emission band of the acceptor as a result of efficient FRET coupling between the acceptor and donor molecules. FRET lasing is characterized for different acceptor and donor concentrations, and threshold pump fluences of acceptor lasing as low as 6.3 mJ cm(-2) are demonstrated. We also verify the dominance of the non-radiative FRET over cavity-assisted radiative energy transfer for the range of parameters studied in the experiments.
https://aperta.ulakbim.gov.trrecord/61177
oai:zenodo.org:61177
info:eu-repo/semantics/openAccess
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LASER PHYSICS LETTERS 11(4)
Optofluidic FRET microlasers based on surface-supported liquid microdroplets
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:37151
2021-03-15T19:45:25Z
user-tubitak-destekli-proje-yayinlari
Coskun, Mahmut
Steinnes, Eiliv
Coskun, Munevver
Cayir, Akin
2009-01-01
In the present work epigeic moss (Hypnum cupressiforme Hedw.) and epigeic lichen (Cladonia rangiformis Hoffm.) samples were collected simultaneously in the Thrace region, Turkey according to a regular sampling grid. Whereas the moss was found at all 68 sampling sites, the lichen could be collected only at 25 of the sites, presumably because lichens are more sensitive than mosses with respect to air pollution and climatic variations. All elements showed higher accumulation in the moss than in the lichen whereas element inter-correlations were generally higher in the lichen. All considered the moss was judged to be a better choice than the lichen for biomonitoring of atmospheric deposition of metals in this case, and it is argued that mosses may be generally more suited than lichens for this purpose.
https://aperta.ulakbim.gov.trrecord/37151
oai:zenodo.org:37151
info:eu-repo/semantics/openAccess
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BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY 82(1) 1-5
Comparison of Epigeic Moss (Hypnum cupressiforme) and Lichen (Cladonia rangiformis) as Biomonitor Species of Atmospheric Metal Deposition
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:76309
2021-03-16T04:37:28Z
user-tubitak-destekli-proje-yayinlari
Lai, Hung-Ming
Ozturk, Celal
Albrecht, Andreas
Steinhoefel, Kathleen
2015-01-01
Gene expression profiles based on high-throughput technologies contribute to molecular classifications of different cell lines and consequently to clinical diagnostic tests for cancer types and other diseases. Statistical techniques and dimension reduction methods have been devised for identifying minimal gene subset with maximal discriminative power. For sets of in silico candidate genes, assuming a unique gene signature or performing a parsimonious signature evaluation seems to be too restrictive in the context of in vitro signature validation. This is mainly due to the high complexity of largely correlated expression measurements and the existence of various oncogenic pathways. Consequently, it might be more advantageous to identify and evaluate multiple gene signatures with a similar good predictive power, which are referred to as near-optimal signatures, to be made available for biological validation. For this purpose we propose the bead-chain-plot approach originating from swarm intelligence techniques, and a small scale computational experiment is conducted in order to convey our vision. We simulate the acquisition of candidate genes by using a small pool of differentially expressed genes derived from microarray-based CNS tumour data. The application of the bead-chain-plot provides experimental evidence for improved classifications by using near-optimal signatures in validation procedures. (C) 2015 Elsevier Ltd. All rights reserved.
https://aperta.ulakbim.gov.trrecord/76309
oai:zenodo.org:76309
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COMPUTATIONAL BIOLOGY AND CHEMISTRY 57 54-60
A new vision of evaluating gene expression signatures
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:23341
2021-03-15T11:14:17Z
user-tubitak-destekli-proje-yayinlari
Tiryaki, Gulgun Yildiz
Akbay, Cuma
2010-01-01
Although consumers' fluid milk consumption behavior related to skim milk, low fat milk and whole milk have attracted a lot of attention in the last decade, relatively a few studies have examined the consumers' unprocessed and processed fluid milk consumption. The objective of this study was to analyze consumers' fluid milk consumption and preference in Turkey by using cross-sectional national survey data. The Chi-square test of independence and multinomial logit procedure were used to investigate the selected socioeconomic and demographic characteristics of consumers that determine households' fluid milk consumption choices between unprocessed fluid milk, processed fluid milk and non-consumption choices. Empirical results indicate that unprocessed fluid milk preference is related positively to household size, number of children in family, household income, and age of housewife; and negatively to education level and employment status of housewife. On the other hand, processed fluid milk preferences are related positively to household income, number of children in households and education level of housewife and negatively to household size and age of housewife.
https://aperta.ulakbim.gov.trrecord/23341
oai:zenodo.org:23341
info:eu-repo/semantics/openAccess
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QUALITY & QUANTITY 44(1) 87-98
Consumers' fluid milk consumption behaviors in TURKEY: an application of multinomial logit model
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:61249
2021-03-16T01:10:49Z
user-tubitak-destekli-proje-yayinlari
Aytimur, Arda
Uslu, Ibrahim
2014-01-01
In this study, PVA/PAA, PVA/PAA/PVP, PVA/PAA/PVP-I and PVA/PAA/PVP/Chitosan fiber mats were prepared via electrospinning. Synthesized nanofibers were characterized by DSC, FT-IR and SEM. DSC results showed that the nanofibers were degraded at 400 degrees C and 450 degrees C. The addition of PVP-K30, PVP-I and chitosan to PVA/PAA structure increased the thermal stability of the nanofibers. SEM micrographs showed that synthesized nanofibers are linear. Fiber diameter measurements showed that average diameters of the fibers are less than 0.5 micron. The average diameters of PVA/PAA, PVA/PAA/PVP, PVA/PAA/PVP-I and PVA/PAA/PVP/Chitosan fibers were calculated as 458nm, 237nm, 139nm, and 270nm, respectively.
https://aperta.ulakbim.gov.trrecord/61249
oai:zenodo.org:61249
info:eu-repo/semantics/openAccess
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POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING 53(7) 655-660
Promising Materials for Wound Dressing: PVA/PAA/PVP Electrospun Nanofibers
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:2895
2021-03-15T05:38:34Z
user-tubitak-destekli-proje-yayinlari
Dogan, Mustafa
Eksi, Kazim Yavuz
2020-01-01
Fast radio bursts (FRBs) are bright, short-duration radio transients with very high brightness temperatures implying highly coherent emission. We suggest that the FRBs are caused by the self-focusing of an electron beam interacting with an ambient plasma right beyond the light cylinder radius of a neutron star. The magnetic field at the light cylinder radius is relatively high that can accommodate both young Crab-like systems and old millisecond pulsars addressing the diverse environments of FRBs. At the first stage, the intense pulsed-beam passing through the background plasma causes instabilities such that the trapped particles in local Buneman-type cavitons saturate the local field. The beam is then radially self-focused due to the circular electric field developed by the two-stream instability that leads to Weibel instability in the transverse direction. Finally, the non-linear saturation of the Weibel instability results in the self-modulational formation of solitons due to plasmoid instability. The resonant solitary waves are the breather-type soli tons hosting relativistic particles with self-excited oscillations. The analytical solutions obtained for non-linear dispersion and solitons suggest that, near the current sheets, the relativistic bunches are accelerated/amplified by klystron-like structures due to self-excited oscillations by the induced local electric field. Boosted coherent radio emission propagates through a narrow cone with strong focusing due to radial electric field and magnetic pinching. The non-linear evolution of solitons and the stimulated emission are associated with the Buneman instability and the possibility of the presence of nanosecond shots in FRBs are investigated.
https://aperta.ulakbim.gov.trrecord/2895
oai:zenodo.org:2895
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MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY 494(1) 876-884
Stimulated emission-based model of fast radio bursts
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:61193
2021-03-16T01:10:01Z
user-tubitak-destekli-proje-yayinlari
Kanmaz, Evrim Ozkaynak
2014-01-01
Subcritical water extraction (SWE) is a technique based on the use of water as an extractant, at temperatures between 100 and 374 degrees C and at a pressure high enough to maintain the liquid state. SWE provides higher selectivities, low cost, and shorter extraction times. In this study, phenolic compounds in flaxseed (Linum usitatissimum L.) meal sticks were extracted with subcritical water using accelerated solvent extractor. For this aim, the interactions between temperature (160, 170, and 180 degrees C) and extraction time (5, 15, 30, and 60 min) for subcritical water extraction of SDG lignan, total phenolics, and total flavonoids from flaxseed meal sticks were investigated. The highest extraction yield of SDG lignan (77.01 %) in subcritical water extracts was determined at 160 degrees C for 60 min. However, high extraction yields were obtained as 70.67 and 72.57 % at 170 and 180 degrees C for 15 min, respectively. Also, the highest extraction yield of total phenolics (70.82 %) and total flavonoids (267.14 %) were determined at 180 degrees C for 15 min. Besides, high correlations between SDG lignan- total phenolics, SDG lignan-total flavonoids, and total phenolics-total flavonoids were obtained from 0.86 to 1 in water extracts.
https://aperta.ulakbim.gov.trrecord/61193
oai:zenodo.org:61193
info:eu-repo/semantics/openAccess
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EUROPEAN FOOD RESEARCH AND TECHNOLOGY 238(1) 85-91
Subcritical water extraction of phenolic compounds from flaxseed meal sticks using accelerated solvent extractor (ASE)
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:83383
2021-03-16T06:13:58Z
user-tubitak-destekli-proje-yayinlari
Kelestimur, Haluk
Ozcan, Mete
Kacar, Emine
Alcin, Ergul
Yilmaz, Bayram
Ayar, Ahmet
2012-01-01
Melatonin is suggested to have effects on hypothalamic-pituitary-gonadal (HPG) axis. The pulsatile pattern of GnRH release, which results in the intermittent release of gonadotropic hormones from the pituitary, has a critical importance for reproductive function but the factors responsible from this release pattern are not known. Calcium is a second messenger involved in hormone release. Therefore, investigation of the effects of melatonin on intracellular free calcium levels ([Ca2+](i)) would provide critical information on hormone release in immortalized GnRH neurons. The pattern of melatonin-induced intracellular calcium signaling was investigated by fluorescence calcium imaging using the immortalized GnRH-secreting GT1-7 hypothalamic neurons. Melatonin caused a significant increase in [Ca2+](i), which was greatly blocked by luzindole, a melatonin antagonist, or attenuated by pre-treatment with protein kinase C inhibitor. This study suggests that melatonin seems to have a direct effect on GnRH neurons. (C) 2011 Elsevier B.V. All rights reserved.
https://aperta.ulakbim.gov.trrecord/83383
oai:zenodo.org:83383
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BRAIN RESEARCH 1435 24-28
Melatonin elicits protein kinase C-mediated calcium response in immortalized GT1-7 GnRH neurons
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:83443
2021-03-16T06:14:50Z
user-tubitak-destekli-proje-yayinlari
Karacaoglu, Elif
Selmanoglu, Guldeniz
Kilic, Aysun
2012-01-01
Aim: To evaluate the toxicity of furan on the thyroid gland, adrenal gland, and pancreas of prepubertal male rats.
https://aperta.ulakbim.gov.trrecord/83443
oai:zenodo.org:83443
info:eu-repo/semantics/openAccess
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TURKISH JOURNAL OF MEDICAL SCIENCES 42 1207-1213
Histopathological effects of the food contaminant furan on some endocrine glands of prepubertal male rats
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:52897
2021-03-15T23:16:26Z
user-tubitak-destekli-proje-yayinlari
Anderson, Ann-Louise
Chen, Shuqun
Romero, Luz
Top, Isil
Binions, Russell
2016-01-01
Functional thin films provide many opportunities for advanced glazing systems. This can be achieved by adding additional functionalities such as self-cleaning or power generation, or alternately by providing energy demand reduction through the management or modulation of solar heat gain or blackbody radiation using spectrally selective films or chromogenic materials. Self-cleaning materials have been generating increasing interest for the past two decades. They may be based on hydrophobic or hydrophilic systems and are often inspired by nature, for example hydrophobic systems based on mimicking the lotus leaf. These materials help to maintain the aesthetic properties of the building, help to maintain a comfortable working environment and in the case of photocatalytic materials, may provide external pollutant remediation. Power generation through window coatings is a relatively new idea and is based around the use of semi-transparent solar cells as windows. In this fashion, energy can be generated whilst also absorbing some solar heat. There is also the possibility, in the case of dye sensitized solar cells, to tune the coloration of the window that provides unheralded external aesthetic possibilities. Materials and coatings for energy demand reduction is highly desirable in an increasingly energy intensive world. We discuss new developments with low emissivity coatings as the need to replace scarce indium becomes more apparent. We go on to discuss thermochromic systems based on vanadium dioxide films. Such systems are dynamic in nature and present a more sophisticated and potentially more beneficial approach to reducing energy demand than static systems such as low emissivity and solar control coatings. The ability to be able to tune some of the material parameters in order to optimize the film performance for a given climate provides exciting opportunities for future technologies. In this article, we review recent progress and challenges in these areas and provide a perspective for future trends and developments.
https://aperta.ulakbim.gov.trrecord/52897
oai:zenodo.org:52897
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BUILDINGS 6(3)
Thin Films for Advanced Glazing Applications
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:52953
2021-03-15T23:17:10Z
user-tubitak-destekli-proje-yayinlari
Yavuz, Murat
Ozer, Zehra Nur
Ulu, Melike
Champion, Christophe
Dogan, Mevlut
2016-01-01
Experimental and theoretical double differential cross sections (DDCSs) for electron-induced ionization of methane (CH4) are here reported for primary energies ranging from 50 eV to 350 eV and ejection angles between 25 degrees and 130 degrees. Experimental DDCSs are compared with theoretical predictions performed within the first Born approximation Coulomb wave. In this model, the initial molecular state is described by using single center wave functions, the incident (scattered) electron being described by a plane wave, while a Coulomb wave function is used for modeling the secondary ejected electron. A fairly good agreement may be observed between theory and experiment with nevertheless an expected systematic overestimation of the theory at low-ejection energies (< 50 eV). Published by AIP Publishing.
https://aperta.ulakbim.gov.trrecord/52953
oai:zenodo.org:52953
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JOURNAL OF CHEMICAL PHYSICS 144(16)
Experimental and theoretical double differential cross sections for electron impact ionization of methane
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:83445
2021-03-16T06:14:52Z
user-tubitak-destekli-proje-yayinlari
Ikhdair, Sameer M.
Hamzavi, Majid
2012-01-01
Approximate analytical solutions of the Dirac equation with Tietz-Hua (TH) potential are obtained for arbitrary spin-orbit quantum number kappa using the Pekeris approximation scheme to deal with the spin-orbit coupling terms kappa(kappa +/- 1)r (-2). In the presence of exact spin and pseudo-spin symmetric limitation, the bound state energy eigenvalues and associated two-component wave functions of the Dirac particle moving in the field of attractive and repulsive TH potential are obtained using the parametric generalization of the Nikiforov-Uvarov method. The cases of the Morse potential, the generalized Morse potential and non-relativistic limits are studied.
https://aperta.ulakbim.gov.trrecord/83445
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FEW-BODY SYSTEMS 53(3-4) 473-486
Approximate Relativistic Bound State Solutions of the Tietz-Hua Rotating Oscillator for Any kappa-State
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:76373
2021-03-16T04:38:20Z
user-tubitak-destekli-proje-yayinlari
Seyitoglu, Gurol
Ecevitoglu, Berkan
Kaypak, Bulent
Esat, Korhan
Caglayan, Ayse
Gundogdu, Oguz
Guney, Yucel
Isik, Veysel
Pekkan, Emrah
Tun, Muammer
Avdan, Ugur
2015-01-01
The North Anatolian Fault Zone (NAFZ) starts to branch off in the western Bolu plain. The branches of the NAFZ in this location create the AlmacA +/- k block which is surrounded by the latest surface ruptures of significant earthquakes that occurred between 1944 and 1999, but its northeastern part remains unruptured. The most recently formed rupture, that was a result of the 1999 November 12 Duzce earthquake, ended to the northwest of the Bakacak Fault. The connection between the Bakacak Fault and the main branch of the NAFZ via the Bolu plain has until now remained unknown. This paper establishes that the route of the missing link runs through the Dagkent, Kasaplar and Burnuk faults, a finding achieved with the help of seismic reflection studies. The paper also argues that the cross cutting nature of these newly determined faults and a stress analysis based on focal mechanism solutions of recent earthquakes demonstrate the termination of the suggested pull-apart nature of the Bolu plain.
https://aperta.ulakbim.gov.trrecord/76373
oai:zenodo.org:76373
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GEOPHYSICAL JOURNAL INTERNATIONAL 201(3) 1814-1833
A missing-link in the tectonic configuration of the AlmacA +/- k Block along the North Anatolian Fault Zone (NW Turkey): Active faulting in the Bolu plain based on seismic reflection studies
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:37137
2021-03-15T19:45:14Z
user-tubitak-destekli-proje-yayinlari
Hasar, Halil
Ipek, Ubeyde
Kinaci, Cumali
2009-01-01
Young leachate was a high strength wastewater with regard to carbon and nitrogen matter, and up to now many researchers have focused on a number of treatment methods to treat the leachate. By using various treatment processes, joint treatment of leachate with domestic wastewater, resulted from same community, is one of the most significant methods because domestic wastewater has either larger mass or lower strength than leachate. In this study, a submerged membrane bioreactor (sMBR) was used for treatment of blending wastewater, including differential mixture ratios of domestic wastewater and leachate. In raw leachate, BOD(5)/COD was between 0.40 and 0.67 and total phosphorus was between 17 and 24 mg/l. After the leachate was blended with domestic wastewater in the ratios of 1/5-1/20, the influent COD decreased from 8,500-14,200 mg/l to 750-2,400 mg/l as ammonium decreased from 1,100-2,150 mg/l to 30-180 mg/l. The sMBR, which was aerated intermittently, accomplished both COD oxidation and nutrient removal at optimal conditions without adding the external phosphorus source, providing < 15mg COD/l, < 1.3 mg NH(4)(+)-N/l, and < 2.0 mg P/l on average at solid retention times (SRT) higher than 10 days. Consequently, the results showed the mixture of leachate and domestic wastewater could be an acceptable alternative by means of membrane bioreactor technology.
https://aperta.ulakbim.gov.trrecord/37137
oai:zenodo.org:37137
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WATER SCIENCE AND TECHNOLOGY 60(12) 3121-3127
Joint treatment of landfill leachate with municipal wastewater by submerged membrane bioreactor
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:235926
2022-10-07T09:31:12Z
user-tubitak-destekli-proje-yayinlari
Fentoglu, Ozlem
Tuluceoglu, Eda Evgen
Orhan, Hikmet
2022-01-01
Background and objective The plasminogen (PLG) activation system plays an essential role in severe inflammation based diseases such as periodontitis, destructive membranous periodontal disease (ligneous periodontitis), familial Mediterranean fever (FMF), and amyloidosis. We have aimed to evaluate variations in PLG and the associations between PLG and MEFV genotypes in patients with FMF/ FMF-related secondary amyloidosis and periodontitis. Material and methods A total of 247 individuals who were either diagnosed with FMF or systemically healthy were recruited to this human observational study with a cross-sectional design. All individuals were also diagnosed with periodontitis or periodontally healthy. Blood samples were obtained from patients with FMF and systemically healthy controls. Clinical periodontal indicators were recorded. All polymorphisms located in exons 6 and 8 of PLG and mutations located on exons 2 and 10 of the MEFV gene were analyzed by DNA Sanger Sequencing. Genotypes and allele frequencies of PLG and MEFV were detected and tested by the Hardy-Weinberg equilibrium. Serum levels of amyloid A (SAA), high-sensitive C-reactive protein (hs-CRP), PLG, and salivary PLG levels were determined by using enzyme-linked immunosorbent assay (ELISA). Results Two polymorphisms were identified in PLG: G to A polymorphism on the 14th nucleotide of intron 8 and C to T polymorphism on the 924th nucleotide of the coding region (IVS 8+14 G>A and c.924C>T, respectively). In IVS 8+14 G>A polymorphisms, wild-type genotype: GG, heterozygote genotype: GA and homozygote genotype: AA. In c.924C>T polymorphism, wild-type genotype: CC, heterozygote genotype: CT and homozygote genotype: TT. The frequency of the heterozygous polymorphisms of PLG was significantly increased (17.6%) in FMF patients with periodontitis (p = .027). A large proportion of the test group that was heterozygous for MEFV-R202Q also had heterozygous PLG polymorphisms. Remarkable exacerbation in periodontal parameters was observed in patients with FMF and amyloidosis. SAA and hs-CRP levels were significantly correlated with salivary PLG levels in patients with periodontitis and heterozygous PLG. Conclusions The current study describes IVS 8+14 G>A (rs2295368) and c.924C>T (rs1380916375) polymorphisms for the first time in the periodontal literature, which might play an important role in the pathogenesis of periodontitis, FMF, or amyloidosis. The elucidation of PLG polymorphisms is beneficial from a public health perspective by increasing the quality of life in these patients and reducing the mortality and morbidity associated with inflammatory diseases such as periodontal disease, FMF, and FMF-related amyloidosis.
https://aperta.ulakbim.gov.trrecord/235926
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JOURNAL OF PERIODONTAL RESEARCH 57(2) 371-380
Plasminogen gene polymorphisms [c.924C > T and IVS 8+14 G > A] in periodontitis and familial Mediterranean fever: A case-control study
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:76393
2021-03-16T04:38:36Z
user-tubitak-destekli-proje-yayinlari
Dicleli, M.
Milani, A. Salem
2015-01-01
A new hysteretic damper for seismic protection of highway bridges is presented. The Multi-directional Torsional Hysteretic Damper (MTHD) works based on torsional yielding of steel cylindrical cores. The device demonstrates a hyperbolic post-elastic stiffness as a result of its special working mechanism which produces this geometric hardening effect. The post-elastic stiffness was found to be effective in limiting the lateral displacement of the seismic-isolated bridge decks in near-fault. Results of nonlinear time history analyses revealed the adaptive behavior of the device which is a result of this gradual hardening feature, such that at lower displacements in Design-Basis Earthquake (DBE), force levels are close to a regular system while at highest levels of displacements in Maximum Considered Earthquake (MCE), the device hardens to make the substructure yield and limit deck's displacement.
https://aperta.ulakbim.gov.trrecord/76393
oai:zenodo.org:76393
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BRIDGE STRUCTURES 11(4) 131-140
An innovative hysteretic damper with adaptive post-elastic stiffness for seismic protection of bridges
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:28489
2021-03-15T12:36:06Z
user-tubitak-destekli-proje-yayinlari
Yilmaz, F.
Oktel, M. O.
2018-01-01
Recent cold atom experiments have realized models where each hyperfine state at an optical lattice site can be regarded as a separate site in a synthetic dimension. In such synthetic ribbon configurations, manipulation of the transitions between the hyperfine levels provide direct control of the hopping in the synthetic dimension. This effect was used to simulate a magnetic field through the ribbon. Precise control over the hopping matrix elements in the synthetic dimensionmakes it possible to change this artificial magnetic field much faster than the time scales associated with atomic motion in the lattice. In this paper, we consider such a magnetic-flux quench scenario in synthetic dimensions. Sudden changes have not been considered for real magnetic fields as such changes in a conducting system would result in large induced currents. Hence we first study the difference between a time varying real magnetic field and an artificial magnetic field using a minimal six-site model. This minimal model clearly shows the connection between gauge dependence and the lack of on-site induced scalar potential terms. We then investigate the dynamics of a wave packet in an infinite two-or three-leg ladder following a flux quench and find that the gauge choice has a dramatic effect on the packet dynamics. Specifically, a wave packet splits into a number of smaller packets moving with different velocities. Both the weights and the number of packets depend on the implemented gauge. If an initial packet, prepared under zero flux in an n-leg ladder, is quenched to Hamiltonian with a vector potential parallel to the ladder, it splits into at most n smaller wave packets. The same initial wave packet splits into up to n(2) packets if the vector potential is implemented to be along the rungs. Even a trivial difference in the gauge choice such as the addition of a constant to the vector potential produces observable effects. We also calculate the packet weights for arbitrary initial and final fluxes. Finally, we show that edge states in a thick ribbon are robust under the quench only when the same gap supports an edge state for the final Hamiltonian.
https://aperta.ulakbim.gov.trrecord/28489
oai:zenodo.org:28489
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PHYSICAL REVIEW A 97(2)
Artificial magnetic-field quenches in synthetic dimensions
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:76345
2021-03-16T04:37:57Z
user-tubitak-destekli-proje-yayinlari
Ozmetin, A. E.
Ongun, E.
Kuru, M.
Yazici, E.
2015-01-01
This study reports micro-fabricated magnet and superconductor (permalloy/Pb82Bi18) hybrid film structures sequentially grown by magnetron sputtering and thermal deposition techniques. 300 nm thick PbBi film was quench condensed on top of a patterned permalloy film. Permalloy film was sputtered and patterned to form few micrometer-wide stripes. Ferromagnetic and superconducting layers were separated by Al2O3 insulation. Transport superconducting properties, i.e. transition temperature T-c(H) and second critical field H-C2(T) were measured in a range of applied magnetic field between H=0 and H=7 kOe for the hybrid system and a control sample with only a layer of superconducting film deposited. The H-C2(T) data showed that due to the interplay between the superconducting film and the ferromagnet, superconducting (SC) and normal current paths formed on the SC film. (C) 2015 Elsevier B.V. All rights reserved.
https://aperta.ulakbim.gov.trrecord/76345
oai:zenodo.org:76345
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APPLIED SURFACE SCIENCE 350 2-5
Fabrication and characterization of ferromagnetic-superconducting hybrid films grown by combined PVD techniques
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:37081
2021-03-15T19:44:29Z
user-tubitak-destekli-proje-yayinlari
Akar, N.
Sohraby, K.
2009-01-01
Markov renewal processes with matrix-exponential semi-Markov kernels provide a generic tool for modeling auto-correlated interarrival and service times in queueing systems. In this paper, we study the steady-state actual waiting time distribution in an infinite capacity single-server semi-Markov queue with the auto-correlation in interarrival and service times modeled by Markov renewal processes with matrix-exponential kernels. Our approach is based on the equivalence between the waiting time distribution of this semi-Markov queue and the output of a linear feedback interconnection system. The unknown parameters of the latter system need to be determined through the solution of a SDC (Spectral-Divide-and-Conquer) problem for which we propose to use the ordered Schur decomposition. This approach leads us to a completely matrix-analytical algorithm to calculate the steady-state waiting time which has a matrix-exponential distribution. Besides its unifying structure, the proposed algorithm is easy to implement and is computationally efficient and stable. We validate the effectiveness and the generality of the proposed approach through numerical examples. (C) 2009 Elsevier B.V. All rights reserved.
https://aperta.ulakbim.gov.trrecord/37081
oai:zenodo.org:37081
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PERFORMANCE EVALUATION 66(11) 587-606
System-theoretical algorithmic solution to waiting times in semi-Markov queues
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:17807
2021-03-15T09:59:38Z
user-tubitak-destekli-proje-yayinlari
Kars, Meltem Demirel
Iseri, Ozlem Darcansoy
Gunduz, Ufuk
2011-01-01
Resistance to the broad spectrum of chemotherapeutic agents in cancer cell lines and tumors has been called multiple drug resistance (MDR). In this study, the molecular mechanisms of resistance to two anticancer agents (paclitaxel and vincristine) in mammary carcinoma cell line MCF-7 were investigated. Drug resistant sublines to paclitaxel (MCF-7/Pac) and vincristine (MCF-7/Vinc) that were developed from sensitive MCF-7 cells (MCF-7/S) were used. cDNA microarray analysis was performed for the RNA samples of sensitive and resistant cells in duplicate experiments. GeneSpring GX 7.3.1 Software was used in data analysis. The results indicated that the upregulation of MDR] gene is the dominating mechanism of the paclitaxel and vincristine drug resistance. Additionally the upregulation of the genes encoding the detoxifying enzymes (i.e. GSTP1) was observed. Significant downregulation of apoptotic genes (i.e. PDCD2/4/6/8) and upregulation of some cell cycle regulatory genes (CDKN2A, CCNA2 etc.) was seen which may be in close relation to MDR in breast cancer. Drug resistant cancer cells exhibit different gene expression patterns depending on drug treatment, and each drug resistance phenotype is probably genetically different. Further functional studies are needed to demonstrate the complete set of genes contributing to the drug resistance phenotype in breast cancer cells. (C) 2011 Elsevier B.V. All rights reserved.
https://aperta.ulakbim.gov.trrecord/17807
oai:zenodo.org:17807
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EUROPEAN JOURNAL OF PHARMACOLOGY 657(1-3) 4-9
A microarray based expression profiling of paclitaxel and vincristine resistant MCF-7 cells
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:43657
2021-03-15T21:10:56Z
user-tubitak-destekli-proje-yayinlari
Olpak, M. A.
Ozpineci, A.
Tanriverdi, V.
2017-01-01
Leading twist light cone distribution amplitudes (LCDAs) are key ingredients in calculating various hadronic amplitudes using light cone QCD sum rules. This work concentrates on calculating the leading twist LCDAs of p-wave heavy quarkonia. Quark model wave functions for the ground, first, and second excited states of p-wave charmonia and bottomonia have been calculated and are used for calculating the relevant LCDAs and leptonic decay constants.
https://aperta.ulakbim.gov.trrecord/43657
oai:zenodo.org:43657
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PHYSICAL REVIEW D 96(1)
Light cone distribution amplitudes of excited p-wave heavy quarkonia at leading twist
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:17865
2021-03-15T10:00:22Z
user-tubitak-destekli-proje-yayinlari
Toraman, O. Y.
2011-01-01
An experimental study on the improvement of particle size distribution of calcite powder (d(50) = 3.23 mu m) was carried out. Ultrafine grinding of calcite powder was studied under batch wet conditions in a laboratory stirred mill. After grinding, the suspension was allowed to age at 30 degrees C for 12 and 24 h. The results indicated that the fineness narrow particle size distribution is influenced to a small extent by altering some operating parameters, such as suspension temperature and aging time. Further increase in the fineness narrow particle size distribution is likely with additional optimization work on the operating parameters of aging process.
https://aperta.ulakbim.gov.trrecord/17865
oai:zenodo.org:17865
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PARTICULATE SCIENCE AND TECHNOLOGY 29(5) 475-480
Use of Wet Grinding and Aging to Produce Narrow Particle Size Distribution
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:229560
2022-10-07T07:36:39Z
user-tubitak-destekli-proje-yayinlari
user-tubitak-adresli-yayinlar
Dogan, Kubra
Erol, Ebru
Orhan, Muge Didem
Degirmenci, Zehra
Kan, Tugce
Gungor, Aysen
Yasa, Belkis
Avsar, Timucin
Cetin, Yuksel
Durdagi, Serdar
Guzel, Mustafa
2022-01-01
Introduction Numerous efforts in natural product drug development are reported for the treatment of Coronavirus. Based on the literature, among these natural plants Artemisia annua L. shows some promise for the treatment of SARS-CoV-2. Objective The main objective of our study was to determine artemisinin content by liquid chromatography electrospray ionisation tandem mass spectrometry (LC-ESI-MS/MS), to investigate the in vitro biological activity of artemisinin from the A. annua plants grown in Turkey with various extracted methods, to elaborate in silico activity against SARS-CoV-2 using molecular modelling. Methodology Twenty-one different extractions were applied. Direct and sequential extractions studies were compared with ultrasonic assisted maceration, Soxhlet, and ultra-rapid determined artemisinin active molecules by LC-ESI-MS/MS methods. The inhibition of spike protein and main protease (3CL) enzyme activity of SARS-CoV-2 virus was assessed by time resolved fluorescence energy transfer (TR-FRET) assay. Results Artemisinin content in the range 0.062-0.066%. Artemisinin showed significant inhibition of 3CL protease activity but not Spike/ACE-2 binding. The 50% effective concentration (EC50) of artemisinin against SARS-CoV-2 Spike pseudovirus was found greater than 50 mu M (EC45) in HEK293T cell line whereas the cell viability was 94% of the control (P < 0.01). The immunosuppressive effects of artemisinin on TNF-alpha production on both pseudovirus and lipopolysaccharide (LPS)-induced THP-1 cells were found significant in a dose dependent manner. Conclusion Further studies of these extracts for COVID-19 treatment will shed light to seek alternative treatment options. Moreover, these natural extracts can be used as an additional treatment option with medicines, as well as prophylactic use can be very beneficial for patients.
https://aperta.ulakbim.gov.trrecord/229560
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PHYTOCHEMICAL ANALYSIS 33(2) 303-319
Instant determination of the artemisinin from various Artemisia annua L. extracts by LC-ESI-MS/MS and their in-silico modelling and in vitro antiviral activity studies against SARS-CoV-2
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:76385
2021-03-16T04:38:30Z
user-tubitak-destekli-proje-yayinlari
Babaei, Naser
Salamci, Metin U.
2015-01-01
A new Model Reference Adaptive Control (MRAC) approach is proposed for the nonlinear regulation problem of cancer treatment via chemotherapy. We suggest an approach for determining an optimal anticancer drug delivery scenario for cancer patients without prior knowledge of nonlinear model structure and parameters by compounding State Dependent Riccati Equation (SDRE) and MRAC which will lead to personalized drug administration. Several approaches have been proposed for eradicating cancerous cells in nonlinear tumor growth model. The main difficulty in these approaches is the requirement of nonlinear model parameters, which are unknown to physicians in reality. To cope with this shortage, we first determine the drug delivery scenario for a reference patient with known mathematical model and parameters via SDRE technique, and by using the proposed approach we adapt the drug administration scenario for another cancer patient despite unknown nonlinear model structure and model parameters. We propose an efficient approach to determine drug administration which will help physicians for prescribing a chemotherapy protocol for a cancer patient by regulating the drug delivery scenario of the reference patient. Stabilizing the tumor growth nonlinear model has been achieved via full state feedback techniques and yields a near optimal solution to cancer treatment problem. Numerical simulations show the effectiveness of the proposed algorithm for eradicating tumor lumps with different sizes in different patients. (C) 2015 Elsevier Ltd. All rights reserved.
https://aperta.ulakbim.gov.trrecord/76385
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JOURNAL OF THEORETICAL BIOLOGY 371 24-44
Personalized drug administration for cancer treatment using Model Reference Adaptive Control
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:83447
2021-03-16T06:14:54Z
user-tubitak-destekli-proje-yayinlari
Koca, Mutlu
Sari, Hikmet
2012-01-01
We present a general upper bounding framework for the average bit error probability of spatial modulation over correlated Rayleigh and Rician channels. The proposed approach provides a closed form upper bound for correlated Rayleigh fading conditions whereas for correlated Rician channels it leads to the numerical evaluation of a single integral formula. The framework is applicable to a general class of linear modulation alphabets and any number of transmit/receive antennas. Theoretical derivations are validated via simulation results.
https://aperta.ulakbim.gov.trrecord/83447
oai:zenodo.org:83447
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Performance Analysis of Spatial Modulation over Correlated Fading Channels
info:eu-repo/semantics/conferencePaper
publication-conferencepaper
oai:zenodo.org:76317
2021-03-16T04:37:34Z
user-tubitak-destekli-proje-yayinlari
Konuklu, Yeliz
Ersoy, Orkun
Gokce, Ozgur
2015-01-01
The high porosity, high oil and water absorption capacity and low density of diatomite make it ideal for industrial applications. The porous structure of diatomite protects phase change materials (PCMs) from environmental factors as a supporting matrix and phase changes occur in nanopores of diatomite. Previous research on diatomite/PCMs composites aimed optimal composite preparation but many methods were feasible only in laboratory scale. In large scale industrial fabrication, easy, continuous and steady state methods are need to be performed. The main purpose of this study was to prepare leakagefree, thermally stable nanocomposite PCMs (nanoCPCMs) by an easy, continuous and steady state method for high temperature thermal energy storage applications. A series of nanoCPCMs with different paraffin:diatomite mass ratios were prepared. The properties of nanoCPCMs have been characterized via scanning electron microscopy (SEM), differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (MR). The leak (exudation) test was performed on prepared composites at higher temperatures (95 degrees C) in comparison with literature. As the optimum composite for thermal energy storage applications, thermal reliability of nanoCPCM was evaluated after 400 cycles of melting and freezing. NanoCPCM melted at 36.55 degrees C with latent heat of 53.1 J/g. (C) 2015 Elsevier Ltd. All rights reserved.
https://aperta.ulakbim.gov.trrecord/76317
oai:zenodo.org:76317
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APPLIED THERMAL ENGINEERING 91 759-766
Easy and industrially applicable impregnation process for preparation of diatomite-based phase change material nanocomposites for thermal energy storage
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:17857
2021-03-15T10:00:16Z
user-tubitak-destekli-proje-yayinlari
Turhan, Mahmut
Abut, Nurettin
2011-01-01
In this study, design principles required for fuel cells to be used in systems that need inrush current are disclosed. The most important difference that separates this study from others is the consideration of utilizing Li-ion batteries to provide power where inrush current is needed in order to spread. In previous studies, lead acid batteries were used instead of Li-ion batteries. Noiselessness and effective electric production ability make fuel cells a good alternative for military applications. The Li-ion battery is the state of the art technology and while advantages include their light weight and the facts that they occupy less space, charge quickly, and have high power intensity, one can experience problems charging because of their charge characteristics. The desired voltage and current can be obtained through serial and parallel implementation of Li-ion batteries. Li-ion batteries and fuel cells are the technology of our day and it is desirable to obtain a more effective system by bringing the advantages of both to the same system. A high efficiency and silent energy is obtained through the use of fuel cells, and Li-ion batteries will enable their use in systems requiring inrush current. Noiseless maneuvering capability in the operational area for a battle ship is a very important factor to preserve. In this study, a way in which these two technologies can be used in cooperation and in an efficient way is described. Fuel cells that have output power 1000 W, output voltage 115 V, and output frequency 60 Hz were tested in the radio room of a corvette of the Turkish Navy. [DOI: 10.1115/1.4003979]
https://aperta.ulakbim.gov.trrecord/17857
oai:zenodo.org:17857
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JOURNAL OF FUEL CELL SCIENCE AND TECHNOLOGY 8(6)
Utilization of Li-Ion Battery Assisted Fuel Cell System in Warships
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:255873
2023-07-29T05:17:55Z
user-tubitak-destekli-proje-yayinlari
Kirpikli, Deniz
2023-01-01
As a second-generation immigrant author Caryl Phillips often depicts the distress of black British people of Afro-Caribbean descent in Britain in his works. His novel In the Falling Snow, published in 2009, illustrates the evolution of the notion of black Britishness through the memory of the post-war generation and more recent transcultural connections. A network of transcultural connections involving the black diaspora and the immigrants from Eastern Europe characterize contemporary England described in the novel. This article argues that the novel gestures towards a more inclusive society through transcultural memory that moves across generations and different immigrant communities. The experience of Eastern Europeans as immigrants echoes the memories of the post-war generation and opens up a space to discuss post-racial possibilities. Thus, the novel provides a perspective to observe the transmission of memory over a couple of decades and the role of migration as a site of transcultural memory.
https://aperta.ulakbim.gov.trrecord/255873
oai:aperta.ulakbim.gov.tr:255873
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NEOPHILOLOGUS 107(2) 329-344
New Ways of Identification: Black Diaspora and Memory in Caryl Phillips's In the Falling Snow
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:236872
2022-10-07T09:46:53Z
user-tubitak-destekli-proje-yayinlari
Xian, Hanbiao
Dong, Xuhui
Li, Yan
Zhan, Nuo
Jeppesen, Erik
2022-01-01
Coastal lagoon sediments provide continuous and high-resolution records of the activity of past typhoons. In this study, multiple proxies were analyzed with a core taken from Pinqing Lagoon located on the northeast margin of the South China Sea. Based on Pb-210 dating, grain sizes and other geophysical/geochemical analyses, a total of seven typhoon-induced layers covering the past similar to 170 years were identified and compared with observational and historical records of typhoons. The layers were characterized by a higher sand fraction, lower loss-on-ignition, decreased magnetic susceptibility, and increased element ratios of Sr/Fe, Sr/Ba, Ca/Ti, and Ca/K. We found reduced sensitivity of the sedimentary response to typhoons due to the coastal geomorphological evolution, such as sand spit growth, which emphasizes the value of using a multiple-proxy approach. The typhoon activity revealed by both sedimentary proxies and observational/historical records in Shanwei was closely related to the variations of the El Nino/Southern Oscillation (ENSO), Pacific Decadal Oscillation (PDO), and to sunspot activity, providing useful clues for reconstructing the long-term typhoon history in the lagoon in order to decipher the patterns and mechanisms of typhoons in South China. (C) 2021 Elsevier B.V. All rights reserved.
https://aperta.ulakbim.gov.trrecord/236872
oai:aperta.ulakbim.gov.tr:236872
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SCIENCE OF THE TOTAL ENVIRONMENT 803
High-resolution reconstruction of typhoon events since similar to 1850 CE based on multi-proxy sediment records in a coastal lagoon, South China
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:52901
2021-03-15T23:16:29Z
user-tubitak-destekli-proje-yayinlari
Al-Turjman, Fadi M.
2016-01-01
Recent research endeavors are capitalizing on the real-time facial disorders detection (RFDD) to utilize available public cameras installed at hospitals' entrances and smart-city streets. These cameras can take images of the infected faces and process it over the free WiFi services which are available everywhere in the Internet of Things (IoT) era. Identifying facial disorders is often subjective and currently done by expert dermatologists. However, with the advances in the IoT enabling technologies and image processing techniques, it is now possible to quantify facial skin disorders using digital photographs in real-time applications. In this paper, we propose a novel real-time approach for abnormal facial regions detection and segmentation over the IoT paradigm.
https://aperta.ulakbim.gov.trrecord/52901
oai:zenodo.org:52901
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Towards Smart eHealth in the Ultra Large-scale Internet of Things Era
info:eu-repo/semantics/conferencePaper
publication-conferencepaper
oai:zenodo.org:52857
2021-03-17T16:52:46Z
user-tubitak-destekli-proje-yayinlari
user-scoap3-turkiye
Demir, Durmus Ali
2016-01-01
It is shown that (a Lambda(2) + b vertical bar H vertical bar(2))R in a spacetime of curvature R is a natural ultraviolet (UV) completion of (a Lambda(4) + b Lambda H-2 vertical bar vertical bar(2)) in the flat-spacetime Standard Model (SM) with Higgs field H, UV scale Lambda, and loop factors a and b. This curvature completion rests on the fact that Lambda-mass gauge theory in flat spacetime turns, on the cut view R = 4 Lambda(2), into a massless gauge theory in curved spacetime. It provides a symmetry reason for curved spacetime, wherein gravity and matter are both low -energy effective phenomena. Gravity arises correctly if new physics exists with at least 63 more bosons than fermions, with no need to interact with the SM and with dark matter as a natural harbinger. It can source various cosmological, astrophysical, and collider phenomena depending on its spectrum and couplings to the SM.
https://aperta.ulakbim.gov.trrecord/52857
oai:zenodo.org:52857
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ADVANCES IN HIGH ENERGY PHYSICS 2016
Curvature-Restored Gauge Invariance and Ultraviolet Naturalness
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:52887
2021-03-15T23:16:19Z
user-tubitak-destekli-proje-yayinlari
Erdogan, Meral
Karaguzel, Remzi
2016-01-01
This study covers the hydrogeologically based works taking place in the drinking water reservoir drainage basin in the Ag. lasun Sub-basin to ensure water quality. The geological units in the Ag. lasun Sub-basin are grouped under two units as allochthonous and autochthonous. Autochthonous units are composed of Erenler limestone, Yazir Formation inside reef limestone, the Ag. lasun Formation seen as flysch and alluvium. Allochthonous units are composed of Akdag. limestone and ophiolitic complex. Autochthonous-positioned limestones with their dissolution cavities are classified as karstic aquifers. There is no hydraulic relationship between autochthonous-positioned limestones and drinking water reservoir. Allochthonous-positioned limestones are classified as karstic aquifers having large number of spring discharges. In the studied basin, a groundwater vulnerability map has been prepared which is an effective tool in determining the water resource protection areas. The DRASTIC method was used when preparing the groundwater vulnerability map. The Groundwater Depth, Net Recharge, Aquifer Type, Soil Media, Topography, Vadose Zone Effect and Hydraulic Conductivity parameters were used to form thematic maps and were evaluated with the help of ArcGIS technology. The most sensitive areas to groundwater are distinctively the areas covered with alluvium and allochthonous limestone. Springs discharging from these sensitive areas recharge the stream that connects to the reservoir. It is therefore understood that the traditional protection areas determined after the maximum water level are inadequate in protecting the water quality in a drinking water basin. In addition to existing protection zones, this study suggests "hydrogeologically based new protection areas'' which also include streams flowing into the reservoir.
https://aperta.ulakbim.gov.trrecord/52887
oai:zenodo.org:52887
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ENVIRONMENTAL EARTH SCIENCES 75(2)
A new hydrogeologically based approach to determining protected areas in drinking water supply reservoirs: a case study in the Ag. lasun sub-basin (Burdur, Turkey)
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:234540
2022-10-07T09:03:25Z
user-tubitak-destekli-proje-yayinlari
Perez-Navarro, Jose
Hermosin-Gutierrez, Isidro
Gomez-Alonso, Sergio
Kurt-Celebi, Aynur
Colak, Nesrin
Hayirlioglu-Ayaz, Sema
Ayaz, Faik A.
Akpinar, Erdal
2022-01-01
BACKGROUND 'Karaerik' is a novel table grape (Vitis vinifera L.) native to Turkey and widely cultivated in areas bordering the city of Erzincan. Because of the demonstrated beneficial effects on human health of the grape phenolic composition, the aim of this work was to conduct a detailed profiling of non-anthocyanin phenolic fractions from different grape tissues of the 'Karaerik' table grape. Both qualitative and quantitative characterization of phenolic compounds were achieved using high-performance liquid chromatography-diode array detection-electrospray ionization-tandem mass spectrometry. Total phenolic content and oxygen radical absorbance capacity were also determined to evaluate the antioxidant properties of this table grape. RESULTS A high number of non-anthocyanin phenolic compounds was identified in 'Karaerik' table grape skins and seeds, including 11 flavonols, six hydroxycinnamic acid derivatives, two stilbenes, several monomeric and dimeric flavan-3-ols and proanthocyanidins. Quercetin-type derivatives dominated the flavonol profile of grape skins, followed by myricetin type. Tartaric acid esters of three acids (caffeic, coumaric and ferulic acids) were the main hydroxycinnamic acid derivatives in this cultivar. Qualitative and quantitative differences were observed in flavan-3-ol composition among the grape tissues. Proanthocyanidins were the most abundant class of phenolic compounds in 'Karaerik' grapes, being mainly located in seeds. Higher antioxidant capacity values were determined in grape seeds, in correlation with the total phenolic content. CONCLUSION These results provide useful information for a better understanding of phenolic antioxidants from the 'Karaerik' table grape and will contribute to promoting the varietal identity and health-related properties of this fruit. (c) 2021 Society of Chemical Industry.
https://aperta.ulakbim.gov.trrecord/234540
oai:aperta.ulakbim.gov.tr:234540
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 102(2) 813-822
Vitis vinifera Turkish novel table grape 'Karaerik'. Part II: Non-anthocyanin phenolic composition and antioxidant capacity
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:235170
2022-10-07T09:14:54Z
user-tubitak-destekli-proje-yayinlari
Oral, Cagatay M.
Ussia, Martina
Yavuz, Derya Kapusuz
Pumera, Martin
2022-01-01
Hybrid microrobots have recently attracted attention due to their ability to combine different energy sources and/or external stimuli for propulsion and performing desired tasks. Despite progresses in the past, on-demand speed modulation for hybrid microrobots has not been analyzed in detail. Herein, the influence of surface properties and crystallite size on the propulsion mechanism of Pt/TiO2 chemical/light-driven hybrid microrobots is investigated. The morphology of urchin-like Pt/TiO2 microrobots leads to "on-the-fly" optical brake behavior under UV irradiation. In contrast, smooth Pt/TiO2 microrobots demonstrate accelerated motion in the same conditions. The comparison between two types of microrobots also indicates the significance of a high surface area and a high crystallite size to increase their speed. The results demonstrate the profound impact of surface features for next-generation smart micro/nanorobots with on-demand reaction capability in dynamically changing environments.
https://aperta.ulakbim.gov.trrecord/235170
oai:aperta.ulakbim.gov.tr:235170
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SMALL 18(10)
Shape Engineering of TiO2 Microrobots for "On-the-Fly" Optical Brake
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:233730
2022-10-07T08:50:30Z
user-tubitak-destekli-proje-yayinlari
Dagdelen, F.
Ozay, C.
Ercan, E.
Emir, G.
Qader, I. N.
2022-01-01
The electrical conductivity is an important behavior of shape memory alloys. It is known that such alloys exhibit different electrical characteristics during phase transformation. In this study, Ni((50-x))Mn39Sn(11)Ta(x) (x = 0, 1, 3) was produced by the arc-melting method under atmosphere control. The phase transformation temperature of these samples was determined by DSC (differential scanning calorimetry) and ER (electrical resistivity) methods. It was found that NiMnSn SMA is a high-temperature shape memory alloy, and the addition of Ta significantly decreased phase transformation temperature of NiMnSn-based SMAs. Besides, it was observed that these alloys exhibited higher resistivity in the martensite phase compared to the austenite phase. The XRD and SEM-EDX were utilized to investigate crystal structure and microstructure of the alloys. Orthorhombic martensite (10 M and 4O) phase picks were found in XRD analysis. In the SEM analysis, on the other hand, grain boundaries, martensite plates, and porous were observed in the samples.
https://aperta.ulakbim.gov.trrecord/233730
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JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY 147(10) 5815-5823
Change of electrical resistivity during phase transitions in NiMnSn-based shape memory alloy
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:233364
2022-10-07T08:40:40Z
user-tubitak-destekli-proje-yayinlari
Karakilic, Emel
Alim, Zuhal
Emirik, Mustafa
Baran, Arif
2022-01-01
In this study, two novel metallophthalocyanines (ZnPc and CoPc) were synthesized using the corresponding metal salts 4-(4-(4-[4-chlorophenyl]-5-methylisoxazol-3-yl)phenoxy)-phthalonitrile (11), prepared from the reaction of 4-nitrophthalonitrile and 4-(4-[4-chlorophenyl]-5-methylisoxazol-3-yl)phenol (9). These metallophthalocyanines (MPcs) showed quite solubility in organic solvents such as dichloromethane (DCM), tetrahydrofuran (THF), dimethyl formamide (DMF), and dimethylsulfoxide (DMSO). The novel compounds 11a and 11b have been characterized using their UV-Vis, FT-IR, H-1 NMR, C-13 NMR, X-Ray, and MALDI-TOF mass spectra. Supporting information cocerning with the study has been supplied. Photochemical, photophysical, and cyclic voltagram properties of these novel 4-(4-(4-[4-chlorophenyl]-5-methylisoxazol-3-yl)phenoxy substituted metallophthalocyanines (11a and 11b) were determined in DMF. DNA binding, metal chelating effect assay, and DPPH [2,2-diphenyl-1-picrylhydrazyl hydrate] radical scavenging assay and electrochemical studies of MPcs were investigated. Further, the inhibitory effects of the COX-inhibitor based novel metallophthalocyanines (11a and 11b) and their ligands (10 and 11) were examined on human erythrocyte carbonic anhydrase I (hCA-I) and II (hCA-II) isoenzymes, and the synthesized molecules exhibited very strong inhibitory effects on both isoforms. In addition, the hCA-I and hCA-II inhibition potential of Zn (II) and Co (II) Phthalocyanine complexes was supported by molecular docking studies. The binding interaction of metallophthalocyanines complexes 11a, 11b enzymes were analyzed in detail.
https://aperta.ulakbim.gov.trrecord/233364
oai:aperta.ulakbim.gov.tr:233364
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APPLIED ORGANOMETALLIC CHEMISTRY 36(3)
Some characteristics of new and innovative COX inhibitor derivatives: Potent hCA-I and hCA-II inhibitors supported by molecular docking studies
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:37045
2021-03-15T19:43:59Z
user-tubitak-destekli-proje-yayinlari
Stan, F.
2008-01-01
In this communication, a class of non-symmetric/symmetric discontinuous Galerkin (dG) methods with interior penalties for interfacial fracture problems is presented. The behaviour of the interface is determined by means of cohesive models depending on the displacement jumps and tractions on the element boundaries. The proposed dG finite element formulation with cohesive models can simplify the computational modeling of failure along well-defined surfaces. Two computational model problems are presented to illustrate the performances of the discontinuous Galerkin method.
https://aperta.ulakbim.gov.trrecord/37045
oai:zenodo.org:37045
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INTERNATIONAL JOURNAL OF MATERIAL FORMING 1 1127-1130
Discontinuous Galerkin Method for Interface Crack Propagation
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:237478
2022-10-07T09:57:06Z
user-tubitak-destekli-proje-yayinlari
Bejan, Adrian
Gunes, Umit
2022-01-01
Here we propose a heat transfer framework for how human-to-human interaction spreads everything on the landscape: disease, goods, knowledge, news, technology, science, language and culture. We show that the phenomenon of "human spreading" shares key features with phenomena that are fundamental in physics (heat, electricity, species, Darcy fluid flow), which spread through continua. As example for discussion and illustration, we construct this theoretical framework by using the early phase of the coronavirus outbreak, from before May 2020. The human spreading phenomenon (S curve) is unveiled systematically by using a minimum of measurable parameters: the number of persons with whom one person comes in contact, the radial size of each step in the growth of the swept territory, the radial scale of the inhabited territory, and the directions in which infrastructure (e.g., air routes) are available for long and fast spreading. The resulting configuration of spreading is a multiscale assembly of clusters of fast channels embedded in interstices with slow diffusion. The configuration is dendritic, where each direction of long and fast spreading is covered by a finger of clusters, and each finger generates its own ramifications. The similarities between this configuration and the dendritic architectures for heat and fluid flow through heterogeneous media are discussed.
https://aperta.ulakbim.gov.trrecord/237478
oai:aperta.ulakbim.gov.tr:237478
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INTERNATIONAL JOURNAL OF THERMAL SCIENCES 174
Virus spreading and heat spreading
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:235714
2022-10-07T09:28:55Z
user-tubitak-destekli-proje-yayinlari
Atila Dincer, Ceren
Getiren, Bengu
Gokalp, Ceren
Ciplak, Zafer
Karakecili, Ayse
Yildiz, Nuray
2022-01-01
Photothermal therapy (PTT) is a new treatment method being developed against traditional cancer therapy methods. In this study, graphene oxide-iron oxide-polypyrrole (GO-Fe3O4-PPy) and iron oxide@polypyrrolenitrogen doped graphene quantum dots (Fe3O4 @PPy-NGQDs) ternary nanocomposites having superior photo thermal and magnetic properties were loaded with doxorubicin (DOX) anticancer drug. The loading and release of the DOX was investigated by UV-visible spectroscopy. At the end of 48 h, the cumulative release of DOX from GO-Fe3O4-PPy/DOX and Fe3O4 @PPy-NGQDs/DOX at pH 5.5 and pH 7.4 was obtained as 99.55% +/- 0.20, 48.87% +/- 0.20% and 97.88% +/- 0.45, 38.82% +/- 0.26, respectively. After a short period of time like 4 h and 8 h, NIR-triggered release of DOX was increased significantly compared to drug release without NIR. The cytotoxic effects on the 4T1 mouse breast cancer cells of GO-Fe3O4-PPy/DOX and Fe3O4 @PPy-NGQDs/DOX drug loaded nanocomposites were determined by MTT test. The increase of DOX release with NIR effect was demonstrated by both in-vitro cytotoxicity studies and confocal laser microscopy images. In summary, multifunctional GO-Fe3O4-PPy/DOX and Fe3O4 @PPy-NGQDs/DOX nanocomposites have great potential for photothermal chemotherapy.
https://aperta.ulakbim.gov.trrecord/235714
oai:aperta.ulakbim.gov.tr:235714
info:eu-repo/semantics/openAccess
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 633
An anticancer drug loading and release study to ternary GO-Fe3O4-PPy and Fe3O4 @PPy-NGQDs nanocomposites for photothermal chemotherapy
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:234478
2022-10-07T09:02:47Z
user-tubitak-destekli-proje-yayinlari
Ucak, Ege
Karagumus, Elif
Sener, Cevat
2022-01-01
Any life event or action can be seen as a potential source of data to analyze. By analyzing such data, we can gain insights into the facts. The situation is no different in public transport. Researchers working in the fields of transport and traffic have stated that such an analysis would be invaluable in designing urban transport and particularly in adapting to current changes. In this study, a scalable public transport analysis platform named Cermoni is developed using the Apache Beam programming model. It can analyze in near-real-time smart card and vehicle location data collected, classified as big data with its high production speed. The performance of the platform was tested on Google Cloud Dataflow service using real-world data gathered from Konya, one of the largest metropolitan cities in Turkey, and the results are discussed in detail.
https://aperta.ulakbim.gov.trrecord/234478
oai:aperta.ulakbim.gov.tr:234478
info:eu-repo/semantics/openAccess
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CONCURRENCY AND COMPUTATION-PRACTICE & EXPERIENCE 34(9)
A scalable platform for big data analysis in public transport
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:233716
2022-10-07T08:50:22Z
user-tubitak-destekli-proje-yayinlari
Mimiroglu, Didem
Yanik, Tulin
Ercan, Batur
2022-01-01
Nerve guidance channels (NGCs) promote cell-extracellular matrix (ECM) interactions occurring within the nanoscale. However, studies focusing on the effects of nanophase topography on neural cell functions are limited, and mostly concentrated on the sub-micron level (>100 nm) surface topography. Therefore, the aim of this study was to fabricate <100 nm sized structures on poly lactic-co-glycolic acid (PLGA) films used in NGC applications to assess the effects of nanophase topography on neural cell functions. For this purpose, nanopit surface arrays were fabricated on PLGA surfaces via replica molding method. The results showed that neural cell proliferation increased up to 65% and c-fos protein expression increased up to 76% on PLGA surfaces having nanophase surface arrays compared to the control samples. It was observed that neural cells spread to a greater extend and formed more neurite extensions on the nanoarrayed surfaces compared to the control samples. These results were correlated with increased hydrophilicity and roughness of the nanophase PLGA surfaces, and point toward the promise of using nanoarrayed surfaces in NGC applications.
https://aperta.ulakbim.gov.trrecord/233716
oai:aperta.ulakbim.gov.tr:233716
info:eu-repo/semantics/openAccess
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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 110(1) 64-75
Nanophase surface arrays on poly (lactic-co-glycolic acid) upregulate neural cell functions
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:230770
2022-10-07T07:57:28Z
user-tubitak-destekli-proje-yayinlari
Asadi, Davood
Ahmadi, Karim
Nabavi, Seyed Yaser
2022-01-01
As a part of emergency landing architecture for multi-rotor, a fault-tolerant trajectory tracking control strategy is proposed in this paper to control a quadcopter in case of a partial motor fault. The introduction of fault-tolerant strategy includes a lightweight fault detection and identification algorithm and a three-loop tracking controller. The lightweight fault detection and identification algorithm identifies the fault based on the controller outputs and the angular rates calculated by a discrete extended Kalman filter. The three-loop controller comprises a cascade structure of a discrete nonlinear adaptive algorithm in the inner-loop and a PID algorithm in the outer-loops of the controller structure. To have more realistic simulations, the gyroscopic effects of rotors and the airframe drag terms are considered in modeling as the model uncertainty. The simulation results demonstrate that the proposed fault-tolerant controller can effectively control the quadcopter in presence of partial motor fault, model uncertainties, and sensor noises. The results also demonstrate the effect of fault detection time delay on the overall control performance.
https://aperta.ulakbim.gov.trrecord/230770
oai:aperta.ulakbim.gov.tr:230770
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INTERNATIONAL JOURNAL OF AERONAUTICAL AND SPACE SCIENCES 23(1) 129-142
Fault-tolerant Trajectory Tracking Control of a Quadcopter in Presence of a Motor Fault
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:234996
2022-10-07T09:12:14Z
user-tubitak-destekli-proje-yayinlari
Yildiz, Ibrahim
Caliskan, Hakan
Mori, Kazutoshi
2022-01-01
In this study, specific biofuel is produced from waste cooking oils and investigated on the basis of "waste-to-fuel/energy" perspective. Then, the fuel properties (viscosity, density, cloud point, flash point, acid number, lower heating values and pour point) of produced biofuel and diesel are obtained. The exhaust emissions resulting from the combustion of the fuels used in the internal combustion diesel engine at 100 Nm load are experimentally investigated. The kinematic viscosity of produced biofuel is found as 6.270 mm(2)/s. However, the kinematic viscosity of diesel fuel is determined as 3.743 mm(2)/s. The use of biofuel is expected to cause more fuel consumption than the use of diesel fuel. The emissions are also affected by this situation. The density of produced biofuel is obtained to be 882 kg/m(3), while the density of diesel fuel is found as 831 kg/m(3). High fuel density affects emissions and engine performance negatively, and biofuel has a higher density value than diesel fuel. It can be concluded that the waste oil derived biofuel affects are different than diesel fuel affects considering same diesel engine for the comparison. So, it is important to generate new types of biofuels to reach the optimum results for the engine and environment.
https://aperta.ulakbim.gov.trrecord/234996
oai:aperta.ulakbim.gov.tr:234996
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SUSTAINABLE ENERGY TECHNOLOGIES AND ASSESSMENTS 50
Assessment of biofuels from waste cooking oils for diesel engines in terms of waste-to-energy perspectives
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:6281
2021-03-15T06:23:29Z
user-tubitak-destekli-proje-yayinlari
Srivastava, Ankur
Saco, Patricia M.
Rodriguez, Jose F.
Kumari, Nikul
Chun, Kwok Pan
Yetemen, Omer
2021-01-01
Previous studies on semi-arid ecosystems have shown high values of soil moisture variability (SMV) primarily induced by the combined effects of non-uniform precipitation, incoming solar radiation, and soil and vegetation properties. However, the relative impact of these various factors on SMV has been difficult to evaluate due to limited availability of field data. In addition, only a limited number of studies have analysed the role of landscape morphology on SMV. Here we use numerical simulations of a simple hydrological model, the Bucket Grassland Model, to systematically analyse the effect of each contributing factor on SMV on two different landscape morphologies. The two different landform morphologies represent landscapes dominated respectively by either diffusive erosion or fluvial erosion processes. We conducted various simulations driven by a stochastically generated 100-year climate time series, which is long enough to capture climatic fluctuations, in order to understand the effect of various soil moisture controlling factors on the spatiotemporal SMV. Our modelling results show that the fluvial dominated landscapes promote higher spatial SMV than the diffusive dominated ones. Further, the role of landform morphology on SMV is more pronounced in regions where the spatial variability of incoming solar radiation and precipitation is high.
https://aperta.ulakbim.gov.trrecord/6281
oai:zenodo.org:6281
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HYDROLOGICAL PROCESSES 35(1)
The role of landscape morphology on soil moisture variability in semi-arid ecosystems
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:232336
2022-10-07T08:23:15Z
user-tubitak-destekli-proje-yayinlari
Bhat, Rouf Ahmad
Singh, Dig Vijay
Qadri, Humaira
Dar, Gowhar Hamid
Dervash, Moonisa Aslam
Bhat, Shakeel Ahmad
Unal, Bengu Turkyilmaz
Ozturk, Munir
Hakeem, Khalid Rehman
Yousaf, Balal
2022-01-01
Dumping waste materials into aquatic ecosystems leads to pollution, which directly and indirectly poses a danger to all life forms. Currently, huge quantities of wastes are generated at a global scale with varying constituents, including organic fractions, emerging contaminants and toxic metals. These wastes release concentrated contaminants (leachates), which are lethal for all ecosystems around the globe because they contain varying concentrations of chemical constituents with BOD5 and COD in the order of 2 x 10(4)-2.7 x 10(4) mg/L, and 3.4 x 10(4)-3.8 x 10(4) mg/L, respectively. Herein, in-depth knowledge of municipal solid waste dumping into the aquatic ecosystems, changes in physicochemical characteristics, availability of in-/organic contaminants, and long-term unhealthy effects are presented. Moreover, an attempt has been made here to summarize the facts related to identifying the deadly impacts of waste on different ecosystem components. The unresolved challenges of municipal waste management are emphasized, which will help employ suitable waste management techniques and technologies to conserve the everlasting freshwater resources on earth.
https://aperta.ulakbim.gov.trrecord/232336
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CHEMOSPHERE 287
Vulnerability of municipal solid waste: An emerging threat to aquatic ecosystems
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:230230
2022-10-07T07:49:50Z
user-tubitak-destekli-proje-yayinlari
Manasoglu, Gizem
Kanik, Mehmet
2022-01-01
In this study, thermal insulation and solar properties of polyester woven fabrics which were coated with micronized perlite having three different particle sizes (10-38, 50-63, and 100-150 mu m) at four different concentrations (20, 40, 60, and 80 g/kg) were investigated. The coating process was performed according to the knife-over-roll method. Thermal measurements were carried out with two different principles to evaluate contact and radiant heat transfer according to JIS R 2618 (testing method for thermal conductivity of insulating fire bricks by hot wire) and EN ISO 6942 (protective clothing-protection against heat and fire-method of test: evaluation of materials and material assemblies when exposed to a source of radiant heat), respectively. Perlite coating enhanced the thermal insulation property of fabrics. The lowest thermal conductivity coefficient and heat transmission factor (0.088 W/mK and 26.83%) values were obtained at the maximum concentration with the biggest size perlite. With the increasing perlite concentration, solar transmittance values decreased for all particle sizes while solar reflectance values increased.
https://aperta.ulakbim.gov.trrecord/230230
oai:aperta.ulakbim.gov.tr:230230
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JOURNAL OF APPLIED POLYMER SCIENCE 139(4)
Investigation of thermal and solar properties of perlite coated woven fabrics
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:28497
2021-03-15T12:36:13Z
user-tubitak-destekli-proje-yayinlari
Erdogan, Ipek
Cosacak, Mehmet Ilyas
Nalbant, Ayten
Akgul, Bunyamin
2018-01-01
MicroRNAs (miRNAs) are small noncoding RNAs of about 19-25 nt that regulate gene expression posttranscriptionally under various cellular conditions, including apoptosis. The miRNAs involved in modulation of apoptotic events in T cells are partially known. However, heterogeneity associated with cell lines makes it difficult to interpret gene expression signatures, especially in cancer-related cell lines. Treatment of the Jurkat T-cell leukemia cell line with the universal apoptotic drug, camptothecin, resulted in identification of two Jurkat subpopulations: one that is sensitive to camptothecin and another that is rather intrinsically resistant. We sorted apoptotic Jurkat cells from nonapoptotic ones prior to profiling miRNAs through deep sequencing. Our data showed that a total of 184 miRNAs were dysregulated. Interestingly, the apoptotic and nonapoptotic subpopulations exhibited distinct miRNA expression profiles. In particular, 6 miRNAs were inversely expressed in these two subpopulations. The pyrosequencing results were validated by real-time qPCR. Altogether, these results suggest that miRNAs modulate apoptotic events in T cells and that cellular heterogeneity requires careful interpretation of miRNA expression profiles obtained from drug-treated cell lines.
https://aperta.ulakbim.gov.trrecord/28497
oai:zenodo.org:28497
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TURKISH JOURNAL OF BIOLOGY 42(2) 113-122
Deep sequencing reveals two jurkat subpopulations with distinct miRNA profiles during camptothecin-induced apoptosis
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:258687
2023-07-29T08:14:39Z
user-tubitak-destekli-proje-yayinlari
Guclu, Harun
Osmanoglu, Serhat
Hayirkus, Aslihan
Tas, Oguzhan
Yazici, Murat
2023-01-01
In this paper, the dynamic compression impact response of an aluminum honeycomb core filled with open-cell foams impregnated with self-healing liquid agents was investigated experimentally. Samples were subjected to a variety of impacts in order to determine healing time and self-healing performance. Three different sandwich specimens were developed to evaluate the effectiveness of self-healing. The sandwich specimens are designated as B (empty honeycomb core cells), S (only open-cell soft polyurethane foam-filled honeycomb core cells), and self-healing agent (SHA) (open-cell soft polyurethane foams impregnated with liquid self-healing agents). The test results were presented by considering the crashworthiness and healing efficiency criteria, and the impact characteristics of the samples were compared related to these criteria. After testing, the results demonstrated that the self-healing agent specimens had much fewer buckling deformation and displacement than their counterparts. Significant improvements were achieved in healing efficiencies and crashworthiness evaluation criteria. The peak load and the energy needed to attain peak load are considered healing efficiency criteria. Self-healing agent specimens reached 29.7% and 12.9% more peak loads, and in the energy absorbed up to peak loads 140% and 34.9% higher values than the B and S sandwiches. In the same samples, crushing strain features were acquired as 50% versus 66%, indicating less displacement in self-healing agent specimens than counterparts. The results indicated that an aluminum honeycomb sandwich structure that can heal itself after damage and recover impact characteristics remarkably could be produced practically.
https://aperta.ulakbim.gov.trrecord/258687
oai:aperta.ulakbim.gov.tr:258687
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PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART L-JOURNAL OF MATERIALS-DESIGN AND APPLICATIONS 237(4) 812-829
An easy-to-implement self-healing smart design for increasing impact strength and crashworthiness resistance of honeycomb sandwich structures
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:28551
2021-03-15T12:37:03Z
user-tubitak-destekli-proje-yayinlari
Sis, Seyit Ahmet
Kavut, Selcuk
2018-01-01
In magnetic resonance-based wireless power transfer systems, the main challenge arises from varying distances between coils during power transfer because distance variations ultimately reduce the power transfer efficiency. Frequency-tuned wireless power transfer systems provide an almost-constant output power to the load up to a critical coupling distance. However, the critical coupling distance and power transfer efficiency are dependent on coil size, source, and load resistances. The purpose of this paper is to discuss this dependency with an equivalent circuit model, determine a suitable coil size for given design specifications, and set up a frequency-tuned system that is based on tracking the resonance frequency at the transmitter side. The coil's lateral size is usually limited by the size of the device to be charged in wireless power transfer applications; therefore, radii of coils are fixed to 25 cm. Coil size is varied by changing the number of turns during simulations. Two identical coils are fabricated based on the simulations using an equivalent circuit model and characterized by S-parameter measurements. A frequency-tuned system is then realized using the fabricated coils, a radiofrequency bidirectional coupler, and a suitable load resistance. Measured power transfer efficiency exhibits good agreement with that predicted by the circuit model. An almost-constant power transfer efficiency of more than 75 % is obtained for up to 24 cm coil separations.
https://aperta.ulakbim.gov.trrecord/28551
oai:zenodo.org:28551
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TURKISH JOURNAL OF ELECTRICAL ENGINEERING AND COMPUTER SCIENCES 26(6) 3168-3180
A frequency-tuned magnetic resonance-based wireless power transfer system with near-constant efficiency up to 24 cm distance
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:232284
2022-10-07T08:22:44Z
user-tubitak-destekli-proje-yayinlari
Erol, Huseyin
Dikmen, Irem
Atasoy, Guzide
Birgonul, M. Talat
2022-01-01
Risk, complexity, and uncertainty are inherent components of megaprojects due to their unique features. However, existing project management practices lack a structured synthesis of these concepts, which leads to unrealistic risk assessments, ineffective management strategies, and poor project performance. In order to fill this gap, this research aims to develop a holistic risk quantification approach incorporating risk-related concepts. For this purpose, a conceptual risk assessment process developed for mega construction projects was operationalized with an Analytic Network Process (ANP) model. The weights of the risk sources in the ANP model were determined by the domain experts through a two-round Delphi study. With the purpose of improving the efficiency and reliability of the knowledge elicitation process, the Delphi study was supported by an interactive data collection tool capable of ANP calculations. The resulting model helped to prioritize the risk sources in mega construction projects. The validity of the findings was tested through the data of 11 mega construction projects. Validation studies revealed the potential of the ANP-based model in quantifying the project risks. Hence, the novel approach proposed in this study is expected to contribute both to the literature by unveiling the interactions between risk-related concepts and to the practitioners by assisting them in assessing the project risks more realistically. Although the risk quantification model has been developed for mega construction projects, it can also be implemented in other project-based industries with minor modifications.
https://aperta.ulakbim.gov.trrecord/232284
oai:aperta.ulakbim.gov.tr:232284
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EXPERT SYSTEMS WITH APPLICATIONS 191
An analytic network process model for risk quantification of mega construction projects
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:231690
2022-10-07T08:13:58Z
user-tubitak-destekli-proje-yayinlari
Boztas, Gullu
Aydogmus, Omur
Guldemir, Hanifi
2022-01-01
This paper presents a motor design which can operate directly with a low-voltage output photovoltaic panels or batteries. A high-efficiency synchronous reluctance motor which can operate directly at low voltage level without a boost converter was designed in this study. The motor was optimized for maximum torque and minimum torque ripple by using the multi-objective genetic algorithm. A robust, durable and low-cost motor structure was obtained due to the obtained rotor structure. The optimized motor can generate less than 5% torque ripple with rated torque of 2 Nm. The prototype motor efficiency was obtained as 81.2% in experimental study, while the motor efficiency designed was obtained as 87.9% in theoretical study. For this reason, the designed motor was suitable for the IE5 efficiency class. However, the experimentally produced prototype motor was obtained in the IE4 efficiency class. In addition, the motor drive and control algorithm were developed for the designed motor. The details were analyzed for different load conditions in both simulation and experimental environments.
https://aperta.ulakbim.gov.trrecord/231690
oai:aperta.ulakbim.gov.tr:231690
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ELECTRICAL ENGINEERING 104(2) 717-725
Design and implementation of a high-efficiency low-voltage synchronous reluctance motor
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:239378
2022-10-07T10:34:38Z
user-tubitak-destekli-proje-yayinlari
Xu, Chao
Wang, Hai-Jun
Li, Yan
Xu, Chi
Yu, Qing
Liu, Miao
Zhang, Miao
Wang, Hong-Zhu
Hamilton, David P.
Jeppesen, Erik
2022-01-01
Loss of submerged macrophytes resulting from high turbidity has become a global environmental problem in shallow lakes, associated with eutrophication. To help macrophyte recovery, application of artificial light-emitting diodes (LEDs) has been proposed to complement nutrient load reductions. We set up a mesocosm experiment to test if LEDs could compensate for shading effects from phytoplankton. We incubated three submerged macrophytes (Vallisneria natans, Myriophyllum spicatum and Ceratophyllum demersum) in 12 tanks of 1000 L under three artificial LED light treatments (red, blue and white) for 94 days in summer. The results showed that 1) growth of V. natans and M. spicatum was stimulated in all the LED light treatments, while C. demersum died in the end of the experiment in all treatments. The growth variables (MLShoot, DMShoot) of V. natans in blue, red and white treatments were 1.8-4.5 times greater than those in the control treatment. For M. spicatum, all plants only survived in the treatments with artificial light supplement. 2) Growing status of V. natans was similar among the treatments of different light colors, while M. spicatum grew best in the red light treatment. The results suggest that artificial light, particularly red light, can promote the recovery of submerged macrophytes in waters where impaired light climate would prevent or delay growth of macrophytes and recovery from eutrophication. Further large-scale field studies are, however, needed to fully elucidate the potential of using artificial light to stimulate growth and recovery of submerged macrophytes in shallow lakes.
https://aperta.ulakbim.gov.trrecord/239378
oai:aperta.ulakbim.gov.tr:239378
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AQUATIC ECOLOGY 56(1) 89-98
Can artificial light promote submerged macrophyte growth in summer?
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:6839
2021-03-15T06:31:05Z
user-tubitak-destekli-proje-yayinlari
Agca, C. A.
2019-01-01
High levels of homocysteine (Hcy) were shown to be a significant independent risk factor for some neurological diseases. Such a condition induces excessive production of reactive oxygen species (ROSs) in human glioma cells. Curcumin, an active component of turmeric (Curcuma longa), provides strong antioxidant effects in in vitro and in vivo experimental models. However, mechanisms of the effect of curcumin against Hcy-induced cell damage have not yet been elucidated in detail. This study investigated whether curcumin can protect cultured U373 glioblastoma cells against Hcy-induced damage, and what are probable cellular mechanisms of this effect, namely, alterations in the expressions of a transcription factor (nuclear E2-related factor-2, Nrf2), hemoxygenase 1 (HO-1), and TP53-induced glycolysis and apoptosis regulator (TIGAR). The results showed that curcumin partially enhanced cell viability of Hcy-treated cells and significantly attenuated intracellular ROS formation. Pretreatment of curcumin also partially moderated Hcy-induced oxidative damage via HO-1 expression through activating Nrf2 expression. Furthermore, TIGAR also contributed to the protective effect of curcumin against cell damage caused by Hcy in the U373 cell line. Taken together, these results indicate that modulation of the Nrf2/HO-1 signal pathway and TIGAR expression can play a pivotal role in the protective effects of curcumin against Hcy-induced oxidative damage in glial cells.
https://aperta.ulakbim.gov.trrecord/6839
oai:zenodo.org:6839
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NEUROPHYSIOLOGY 51(6) 416-423
Homocysteine-Induced Damage of Cultured Glioblastoma Cells: Amelioration by Curcumin
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:236772
2022-10-07T09:45:24Z
user-tubitak-destekli-proje-yayinlari
Beker, Mustafa C.
Caglayan, Ahmet B.
Altunay, Serdar
Ozbay, Elif
Ates, Nilay
Kelestemur, Taha
Caglayan, Berrak
Kilic, Ulkan
Doeppner, Thorsten R.
Hermann, Dirk M.
Kilic, Ertugrul
2022-01-01
Phosphodiesterase 10A (PDE10A) hydrolyzes adenosine 3 ',5 '-cyclic monophosphate (cAMP) and guanosine 3 ',5 '-cyclic monophosphate (cGMP). It is highly expressed in the striatum. Recent evidence implied that PDE10A may be involved in the inflammatory processes following injury, such as ischemic stroke. Its role in ischemic injury was unknown. Herein, we exposed mice to 90 or 30-min middle cerebral artery occlusion, followed by the delivery of the highly selective PDE10A inhibitor TAK-063 (0.3 mg/kg or 3 mg/kg) immediately after reperfusion. Animals were sacrificed after 24 or 72 h, respectively. Both TAK-063 doses enhanced neurological function, reduced infarct volume, increased neuronal survival, reduced brain edema, and increased blood-brain barrier integrity, alongside cerebral microcirculation improvements. Post-ischemic neuroprotection was associated with increased phosphorylation (i.e., activation) of pro-survival Akt, Erk-1/2, GSK-3 alpha/beta and anti-apoptotic Bcl-xL abundance, decreased phosphorylation of pro-survival mTOR, and HIF-1 alpha, MMP-9 and pro-apoptotic Bax abundance. Interestingly, PDE10A inhibition reduced inflammatory cytokines/chemokines, including IFN-gamma and TNF-alpha, analyzed by planar surface immunoassay. In addition, liquid chromatography-tandem mass spectrometry revealed 40 proteins were significantly altered by TAK-063. Our study established PDE10A as a target for ischemic stroke therapy.
https://aperta.ulakbim.gov.trrecord/236772
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MOLECULAR NEUROBIOLOGY 59(1) 574-589
Phosphodiesterase 10A Is a Critical Target for Neuroprotection in a Mouse Model of Ischemic Stroke
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:76335
2021-03-16T04:37:49Z
user-tubitak-destekli-proje-yayinlari
Karpuz, Ceyhun
Gorur, Ali Kursad
Sahin, Engin
2015-01-01
In this letter, a dual-mode dual-band microstrip bandpass filter design with center frequency control methodology is presented by using dual-mode meandered loop resonator. Center frequencies of the passbands can be controlled by changing the connection points of internally located square loop loading elements without changing the total surface area. These loading elements are also useful to obtain a compact configuration. In addition, while the first passband has two reflection zeros, the second passband has one reflection zero, as it is obtained from the harmonic of the first passband. Therefore, degenerate modes of the first passband can be excited by a perturbation element. Using patch or corner cut perturbation elements, elliptical and linear phase filtering characteristics can be obtained in the first passband, respectively. Two dual-mode microstrip bandpass filters having elliptical and linear phase filtering characteristics were designed, fabricated, and measured. Measured results are in a very good agreement with the results. (C) 2015 Wiley Periodicals, Inc.
https://aperta.ulakbim.gov.trrecord/76335
oai:zenodo.org:76335
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MICROWAVE AND OPTICAL TECHNOLOGY LETTERS 57(3) 639-642
DUAL-MODE DUAL-BAND MICROSTRIP BANDPASS FILTER WITH CONTROLLABLE CENTER FREQUENCY
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:261863
2023-07-29T15:36:05Z
user-tubitak-destekli-proje-yayinlari
Sadigova, S. R.
2023-01-01
The concept of mu-strong Cesaro summability at infinity for a locally integrable function is introduced in this work. The concept of mu-statistical convergence at infinity is also considered and the relationship between these two concepts is established. The concept of mu [p]-strong convergence at infinity point, generated by the measure mu (.) is also considered. Similar results are obtained in this case too. This approach is applied to the study of the convergence of the Fourier-Stieltjes transforms.
https://aperta.ulakbim.gov.trrecord/261863
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ARABIAN JOURNAL OF MATHEMATICS 12(1) 233-245
On mu-strong Cesaro summability at infinity and its application to the Fourier-Stieltjes transforms
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:28617
2021-03-15T12:37:59Z
user-tubitak-destekli-proje-yayinlari
Akkar, Sinan
Moghimi, Saed
2018-01-01
Near-fault ground motions exhibiting forward directivity effects are critical for seismic design because they impose very large seismic demands on buildings due to their large-amplitude pulselike waveforms. The current challenge in seismic design codes is to recommend simple (easy-to-apply) yet proper rules to explain the near-fault forward directivity (NFFD) phenomenon for seismic demands. This effort is not new and has been the subject of research for over two decades. This paper contributes to these efforts and proposes an alternative set of rules to modify the elastic design spectrum of 475-year and 2475-year return periods for NFFD effects. The directivity rules discussed here are evolved from a relatively large number of probabilistic earthquake scenarios (probabilistic seismic hazard assessment, PSHA) that employ two recent directivity models. The paper first gives the background of the probabilistic earthquake scenarios and then introduces the proposed NFFD rules for seismic design codes. We conclude the paper by presenting some cases with the proposed rules to see how spectral amplitudes modify due to directivity.
https://aperta.ulakbim.gov.trrecord/28617
oai:zenodo.org:28617
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Implementation of Near-Fault Forward Directivity Effects in Seismic Design Codes
info:eu-repo/semantics/conferencePaper
publication-conferencepaper
oai:aperta.ulakbim.gov.tr:230308
2022-10-07T07:50:42Z
user-tubitak-destekli-proje-yayinlari
Sahin, Koray
Bozdogan, Adnan
Yasar, Kurban
Eker, Tulin
Kabak, Bulent
2022-01-01
Aflatoxins (AFs) are genotoxic carcinogens and are a growing concern in peanuts and peanut products. This study aims to impact of different extraction processes on the transition of AFs from peanuts to oils. Peanuts were collected from nine different factories in Osmaniye, Turkey, during the period of November 2017-May 2018. While no aflatoxin G(1) (AFG(1)) and aflatoxin G(2) (AFG(2)) were detected in peanuts, aflatoxin B-1 (AFB(1)) and aflatoxin B-2 (AFB(2)) were determined in all peanut samples at levels varying from 26.7 to 234.7 mu g kg(-1) and from 4.44 to 44.0 mu g kg(-1), respectively. No AFs were quantified in oils obtained by the industrial application method. The ratios of AFB(1) transitions to oils obtained by solvent extraction, cold pressing of roasted peanuts and cold pressing methods were 9.0-79.8%, 11.3-75.3% and 9.3-77.6%, respectively. The concentrations of AFB(2) in oils obtained by solvent extraction, cold pressing of roasted peanuts and cold pressing methods were 0.46-17.2 mu g kg(-1), 0.84-33.0 mu g kg(-1) and 1.02-36.3 mu g kg(-1), respectively. This is the first demonstration of the impact of different extraction processes on the transition of AFs from peanuts to oils.
https://aperta.ulakbim.gov.trrecord/230308
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JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE 59(7) 2741-2750
Impact of different extraction processes on aflatoxin contamination in peanut oil
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:37115
2021-03-15T19:44:56Z
user-tubitak-destekli-proje-yayinlari
Bohm, Arno
Uncu, Haydar
Komy, S.
2009-01-01
The mathematics of quantum physics started from matrices and from differential operators. It inspired the theory of linear operators in Hilbert space and of unitary representation for symmetry groups and spectrum generating groups. The Dirac bra-ket formalism led first to Schwartz's theory of distributions and then to its generalization, the Rigged Hilbert Space (RHS) or Gelfand triplet. This Schwartz-RHS provided the mathematical justification for Dirac's continuous basis vector expansion and for the algebra of continuous observables of quantum theory. To obtain also a mathematical theory of scattering, resonance and decay phenomena one needed to make a mathematical distinction between prepared in-states and detected observables ("out-states"). This leads to a pair of Hardy RHS's and using the Paley-Wiener theorem, to solutions of the dynamical equations (Schrodinger or Heisenberg) given by time-asymmetric semi-groups, expressing Einstein causality.
https://aperta.ulakbim.gov.trrecord/37115
oai:zenodo.org:37115
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REPORTS ON MATHEMATICAL PHYSICS 64(1-2) 5-32
A BRIEF SURVEY OF THE MATHEMATICS OF QUANTUM PHYSICS
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:257203
2023-07-29T07:23:52Z
user-tubitak-destekli-proje-yayinlari
Kilic, Burcu
Bardakkaya, Merve
Sagkan, Rahsan Ilikci
Aksakal, Fatma
Shakila, Shakila
Dogruer, Deniz S.
2023-01-01
In this study, two series of compounds were designed and synthesized, bearing thiourea and benzamide derivatives at position 2 of 4-subtituted-2-aminothiazole, respectively. Then, the inhibition potency of all final compounds for cholinesterase enzymes were evaluated. Among the thiourea derivatives, 3c (IC50 = 0.33 mu M) was identified as the most potent and selective butyrylcholinesterase inhibitor. Additionally, benzamide derivative 10e (AChE IC50 = 1.47 and BChE IC50 = 11.40 mu M) was found as a dual cholinesterase inhibitor. The type of inhibition for both compounds was determined by kinetic studies and the results showed that the compounds were mixed type inhibitors. Moreover, all title compounds were investigated in terms of their antioxidant (DPHH, ORAC) and metal chelator activities. In addition, the neuroprotective effects of selected compounds (3c, 3e, 6c, 6e and 10e) against H2O2-induced damage in the PC12 cell line were tested. The experimental findings demonstrated that thiourea-derived 6e (40.4 %) and benzamide-derived 10e (37.8 %) have a neuroprotective effect of about half as ferulic acid at 10 mu M. Subsequently, the cytotoxicity of selected compounds was examined by the MTT assay, and the compounds were found not to have cytotoxic effect on the PC12 cell line in 24 h. Additionally, compounds 6e and 10e were also found to be more effective in inhibiting the release of IL-1 beta, IL-6, TNF-alpha and NO compared to other selected compounds in this study.
https://aperta.ulakbim.gov.trrecord/257203
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BIOORGANIC CHEMISTRY 131
New thiourea and benzamide derivatives of 2-aminothiazole as multi-target agents against Alzheimer?s disease: Design, synthesis, and biological evaluation
info:eu-repo/semantics/article
publication-article
oai:zenodo.org:43653
2021-03-15T21:10:53Z
user-tubitak-destekli-proje-yayinlari
Baylam, Isinsu
Ozharar, Sarper
Kakenov, Nurbek
Kocabas, Coskun
Sennaroglu, Alphan
2017-01-01
We experimentally show that a voltage-controlled graphene-gold supercapacitor saturable absorber (VCG-gold-SA) can be operated as a fast saturable absorber with adjustable linear absorption at wavelengths as low as 795 nm. This was made possible by the use of a novel supercapacitor architecture, consisting of a high-dielectric electrolyte sandwiched between a graphene and a gold electrode. The high-dielectric electrolyte allowed continuous, reversible adjustment of the Fermi level and, hence, the optical loss of the VCG-gold-SA up to the visible wavelengths at low bias voltages of the order of a few volts (0-2 V). The fast saturable absorber action of the VCG-gold-SA and the bias-dependent reduction of its loss were successfully demonstrated inside a femtosecond Ti3+ : sapphire laser operating near 800 nm. Dispersion compensation was employed by using dispersion control mirrors and a prism pair. At a bias voltage of 1.2 V, the laser operated with improved power performance in comparison with that at zero bias, and the VCG-gold-SA initiated the generation of nearly transform-limited pulses as short as 48 fs at a pulse repetition rate of 131.7MHz near 830 nm. To the best of our knowledge, this represents the shortest wavelength where a VCG-gold-SA has been employed as a mode locker with adjustable loss. (C) 2017 Optical Society of America
https://aperta.ulakbim.gov.trrecord/43653
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OPTICS LETTERS 42(7) 1404-1407
Femtosecond pulse generation from a Ti3+: sapphire laser near 800 nm with voltage reconfigurable graphene saturable absorbers
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publication-article
oai:zenodo.org:61225
2021-03-16T01:10:31Z
user-tubitak-destekli-proje-yayinlari
Gunhan, Tuncay
Ekren, Orhan
Demir, Vedat
Hepbasli, Arif
Erek, Aytunc
Sahin, Arzu Sencan
2014-01-01
This study proposes a novel solar assisted absorption cooling (SAAC) system and performs its exergetic analysis and assessment. The system was designed, constructed and tested in Izmir, Turkey. Water was used as refrigerant in the system. The performance of the whole system along with its main components was assessed through exergy analysis method. The results obtained gave the exergy destruction rate, the exergy efficiency in various forms, the relative irreversibility and sustainability index in both charging and discharging processes. A parametric study was also undertaken to investigate the effect of the various dead (reference) state temperatures ranging from 30 degrees C to 42 degrees C with an interval of 4 degrees C on the entire system efficiency. In this context, the exergy efficiency of the whole system varied between 13.1 and 43.2% as the dead state temperatures increase from 30 degrees C to 42 degrees C. The highest relative irreversibility values of 66.1% and 34.6% belonged to the solar collectors and the absorption chiller in charging and discharging processes at a dead state temperature of 34 degrees C, respectively. (C) 2013 Elsevier B.V. All rights reserved.
https://aperta.ulakbim.gov.trrecord/61225
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ENERGY AND BUILDINGS 68 138-146
Experimental exergetic performance evaluation of a novel solar assisted LiCl-H2O absorption cooling system
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publication-article
oai:aperta.ulakbim.gov.tr:261099
2023-07-29T14:37:16Z
user-tubitak-destekli-proje-yayinlari
Yilmaz, Harun
Karyeyen, Serhat
Tepe, Ahmet Umit
Bruggemann, Dieter
2023-01-01
Colorless distributed combustion technique enables less pollutants emissions for a fuel/oxidizer mixture to be combusted. In this study, colorless distributed combustion characteristics (CDC) of hydrogen/air mixtures were numerically investigated in a micro combustor to overcome the difficulties associated with micro combustion and to obtain a more uniform temperature profile on the outer wall. To that end, hydrogen/air combustion was simulated by using ANSYS/Fluent CFD code at a constant equivalence ratio (1.0) and thermal input (100 W) and different mixture inlet temperatures of 300 K, 600 K and 1000 K to seek colorless distributed combustion. CDC conditions were tried to be achieved by decreasing the oxygen concentration from 21 % to 9 % at an interval of 3 %. In conclusion, colorless distributed combustion conditions could be achieved at different O2 concentrations, irrespective of the mixture inlet temperature. At 300 and 600 K, such conditions did not make any positive contribution to the power output of the micro combustor. Nevertheless, at 1000 K and 9 % O2 concentration, all combustion and emission performance metrics were improved in a manner that could increase the power output of the micro power generator.
https://aperta.ulakbim.gov.trrecord/261099
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FUEL 332
Colorless distributed combustion characteristics of hydrogen/air mixtures in a micro combustor
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publication-article
oai:aperta.ulakbim.gov.tr:256965
2023-07-29T07:12:18Z
user-tubitak-destekli-proje-yayinlari
Oz, Yunus Emre
Kalender, Mehmet
2023-01-01
In bacterial cellulose (BC) production, we developed a new static cultivation system named series static culture (SSC) to eliminate air limitation problem encountered in conventional static culture (CSC). In SSC system, the fermentation broth at the bottom of BC pellicle produced in initial culture medium is transferred to the next empty sterile culture medium at the end of a certain fermentation period. This procedure was performed until BC production ceased. Fermentation experiments were carried out using Gluconacetobacter xylinus NRRL B-759 and sugar beet molasses at 30 degrees C and initial pH 5. Also, some quality parameters of produced BC pellicles were determined. Final pH at the stages of SSC system was higher that of the initial pH due to sugar content (sucrose) of molasses and microorganism used. Total BC production increased with increasing sugar concentration in SSC. As a result, an increase of 22.02 % in BC production was achieved using developed SSC. FT-IR spectra of all BC pellicles produced were typical spectra. The absorption bands at the relevant wavenumbers identify the mode of vibrations of the created chemical bonds arising at the BC surface such as O-H, C-H, H-O-H, C-O-C, and C-OH. XRD analyses showed that the crystallinity index values of BC obtained from CCS and SSC were high. The form of produced all BC pellicles is generally Cellulose I. Removal of surface moisture and depolymerisation of carbon skeleton were determined from TGA-DTA thermograms. SEM images showed that the BC samples produced had nano-sized cellulose fibrils which were aggregated in fermentation media containing molasses. Finally, the BC samples, especially in molasses media, having high mechanical strength and WHC were found.
https://aperta.ulakbim.gov.trrecord/256965
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 225 1306-1314
A novel static cultivation of bacterial cellulose production from sugar beet molasses: Series static culture (SSC) system
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publication-article
oai:aperta.ulakbim.gov.tr:260377
2023-07-29T10:51:07Z
user-tubitak-destekli-proje-yayinlari
Mutlu, Erhan
Karaca, Dogukan
Duman, Guler Sila
Sahin, Ahmet
Ozvarol, Yasar
Olguner, Cansu
2023-01-01
Epiphytes on Posidonia oceanica play a crucial role for determination of the ecological status of marine environment in time and space besides the seagrasses alone. The study was aimed to estimate the spatiotemporal ecological status linked to variation in biometry of an epiphytic micro-calcareous red alga, Hydrolithon boreale, found on leaves of the meadow with the exclusive environmental parameters along the entire Turkish coast of the Mediterranean Sea. Collection of Posidonia oceanica samples was conducted at 64 stations in winter (December 2018-January 2019) and 112 stations in summer (June-July 2019) by SCUBA (0.4 x 0.4 m of a quadrate frame) in the infralittoral zone along the entire Turkish Mediterranean coast surrounded by the siliciclastic Taurus Mountain Range which favor growth of epiphytic micro-calcareous red algae. Percent occurrence of the epiphyte changed seasonally-lower in winter (25%) than in summer (44%). The epiphyte which is an indicator and sensitive to undisturbed marine area grew up well to 5 mm in diameter, 0.35 mm in thickness of the crust size, and was populated up to 1006 ind/m(2) in summer owing to the increased utilization of the carbonate by the epiphyte with the increased water temperature. The size was contrasted to the density (abundance and biomass) in space. The biometry was significantly dependent on the siliciclastic-carbonate deposition as inferred from SiO4-Si of the water in relation to the leaf area index (LAI) of P. oceanica. Therefore, this deposition induced specimens to grow in size, followed by the reduced density concerning the N-based nutrient of the water. Further major environmental parameters which negatively affected the biometry were pH and total suspended matter of the water, analogous to turbidity. Of the trace elements, Ni was negatively correlated with the biometry, whereas the LAI was however positively correlated with all the anthropogenic-sourced trace elements (V, Cu, Zn, As, Cd, and Pb) in the leaves. Of the bottom types, the calcite rock had a higher density than the other soft bottoms in contrast to the size of the epiphyte. Future studies could be based on the present study for determination of the ecological status regarding two dominant epiphytes on leaves of two seagrasses (H. boreale on P. oceanica and partly Pneophyllum fragile on Cymodocea nodosa) found in the different environments and substrates in space and time.
https://aperta.ulakbim.gov.trrecord/260377
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 30(7) 17193-17213
Seasonality and phenology of an epiphytic calcareous red alga, Hydrolithon boreale, on the leaves of Posidonia oceanica (L) Delile in the Turkish water
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:254339
2023-07-28T20:53:11Z
user-tubitak-destekli-proje-yayinlari
Talibova, Gunel
Bilmez, Yesim
Ozturk, Saffet
2023-01-01
DNA double-strand breaks (DSBs) are commonly appearing deleterious DNA damages, which progressively increase in male germ cells during biological aging. There are two main pathways for repairing DSBs: homologous recombination (HR) and classical nonhomologous end joining (cNHEJ). Knockout and functional studies revealed that, while RAD51 and RPA70 proteins are indispensable for HR-based repair, KU80 and XRCC4 are the key proteins in cNHEJ repair. As is known, gamma H2AX contributes to these pathways through recruiting repair-related proteins to damaged site. The underlying reasons of increased DSBs in male germ cells during aging are not fully addressed yet. In this study, we aimed to analyze the spatiotemporal expression of the Rad51, Rpa70, Ku80, and Xrcc4 genes in the postnatal mouse testes, classified into young, prepubertal, pubertal, postpubertal, and aged groups according to their reproductive features and histological structures. We found that expression of these genes significantly decreased in the aged group compared with the other groups (P < 0.05). gamma H2AX staining showed that DSB levels in the germ cells from spermatogonia to elongated spermatids as well as in the Sertoli cells remarkably increased in the aged group (P < 0.05). The RAD51, RPA70, KU80, and XRCC4 protein levels exhibited predominant changes in the germ and Sertoli cells among groups (P < 0.05). These findings suggest that altered expression of the Rad51, Rpa70, Ku80, and Xrcc4 genes in the germ and Sertoli cells may be associated with increasing DSBs during biological aging, which might result in fertility loss.
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HISTOCHEMISTRY AND CELL BIOLOGY 159(2) 127-147
Increased double-strand breaks in aged mouse male germ cells may result from changed expression of the genes essential for homologous recombination or nonhomologous end joining repair
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:257745
2023-07-29T07:41:36Z
user-tubitak-destekli-proje-yayinlari
Yilmaz, Erkan
Baghban, Neda
Soylak, Mustafa
2023-01-01
A novel high-efficient sorbent composed of polyaniline (PANI), MoS2 nanoparticles, and multiwalled carbon nanotubes (MWCNTS) was synthesized and used for the extraction and preconcentration of salmon sperm DNA for the first time. For the effective adsorption of the DNA chain, which has many interacting functional groups, the ability of the MoS2 in the sandwich-like structure to adsorb analytes was combined with the hydrogen bonding ability of the PANI polymer and the high adsorption capacity of MWCNTs with high surface area. With the awareness of the importance of DNA extraction and preconcentration studies, salmon sperm DNA was selected to be the analyte in this study. After rapid extraction and preconcentration of salmon sperm DNA, inexpensive and easy analysis was performed by spectrophotometry that is available in almost every laboratory. This method has the potential to be routinely used in DNA extraction and determination from various media. The characterization of synthesized PANI@MoS2@ MWCNTs was carried out using Fourier transform infrared spectroscopy, Raman spectroscopy, X-ray diffraction, field emission scanning electron microscopy, scanning electron microscopy mapping, and energy dispersive X-ray spectroscopy. Spectrophotometry at 260 nm was used to determine the DNA. The optimum extraction conditions of the SPE procedure were pH 6.0, 25 of mg adsorbent, 2 min of vortexing, and 1 mL of 2 M sodium hydroxide as the eluent. Under the optimal conditions, the calibration curve was linear from 33 to 567 mu g L-1, the relative standard deviation was 2.2% for 100 mu g L-1, and the limit of detection limit was 13 mu g L-1. The maximum obtained preconcentration factor was 30 and the sorption capacity of synthesized adsorbent for DNA was 9.16 mg g(-1).
https://aperta.ulakbim.gov.trrecord/257745
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ANALYTICAL LETTERS 56(10) 1632-1645
Solid-Phase Extraction (SPE) of Salmon Sperm DNA Using a Polyaniline@Molybdenum(IV) Sulfide@Multiwalled Carbon Nanotubes (MWCNTs) Nanocomposite with Spectrophotometric Detection
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:253837
2023-07-28T19:51:22Z
user-tubitak-destekli-proje-yayinlari
Doguer, Caglar
Akalan, Hande
Demirok, Nazan Tokatli
Erdal, Berna
Mete, Rafet
Bilgen, Turker
2023-01-01
Purpose The aim of this study was to establish whether Acetobacter ghanensis, the probiotic characteristics of which were evaluated previously, attenuates gliadin-induced toxicity in intestinal epithelial cells with gluten-digestive and immunoregulatory properties.
https://aperta.ulakbim.gov.trrecord/253837
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EUROPEAN JOURNAL OF NUTRITION 62(2) 605-614
Protective effects of Acetobacter ghanensis against gliadin toxicity in intestinal epithelial cells with immunoregulatory and gluten-digestive properties
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:257693
2023-07-29T07:39:57Z
user-tubitak-destekli-proje-yayinlari
Ozaslan, Zeynep Tugba
Ibanoglu, Senol
2023-01-01
Effect of various ozonation durations (i.e., 15, 30, and 60 min) on selected properties of gum arabic with 0.5% concentration (db), corn starch (S) and corn starch-gum arabic dispersion (GAS) were investigated. Ozonation generally caused significant decrease in viscosity of samples (P < 0.05), providing potential ease of use in industry. Peak temperature of GAS was increased after 60 min ozonation (P < 0.05), as measured by differential scanning calorimeter. The pH values decreased after for each ozonation period (15, 30 and 60 min) (pH 5.0 to pH 2.50), due to possible hydroxyl oxidation by ozonation, which was linked to increased formation of carbonyl and carboxyl groups. It was observed that ozonation resulted in increased water solubility index whereas a decrease was observed in water adsorption index. Ozonation increased the quantity of reducing sugars (19.3%), phenolic compound concentrations (24.0%) and radical scavenging activity (48.0%) compared to control samples after 60 min ozonation. This study suggests that ozonation could be used to oxidize GAS dispersions by an environment friendly approach.
https://aperta.ulakbim.gov.trrecord/257693
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JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION 17(2) 1186-1198
Use of ozonation, a green oxidation method, in the modification of corn starch-gum arabic suspensions: thermal, rheological, functional and antioxidant properties
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:256393
2023-07-29T05:50:59Z
user-tubitak-destekli-proje-yayinlari
Unal, A.
Akkus, N.
2023-01-01
In this study, the effects of using coke dust in brake pad mixtures against the problem of friction coefficient reduction occurring at high temperatures in railway vehicle brake pads were investigated. For this purpose, the average friction coefficients and wear rates of the brake pads produced by using different amounts of coke dust were tested with the help of a dynamometer at different temperature values and the brake pad mixture containing coke dust with optimum ratio was determined. Brake pads with optimum coke dust ratio were tested in a train set under real railway conditions and the stopping distances of the train set and the temperatures during braking were measured. Using the stopping distances measured during railway tests and the average friction coefficients of the brake pads were analyzed analytically and compared with the dynamometer results. As a result of these tests, it has been observed that the coke dust material reduces the friction coefficient at low temperatures, but increases the friction coefficient at high temperatures and significantly reduces the amount of wear.
https://aperta.ulakbim.gov.trrecord/256393
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PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART F-JOURNAL OF RAIL AND RAPID TRANSIT 237(2) 218-223
Analytical and experimental investigation of composite pads created by using coke dust against the fading problem in railway vehicles
info:eu-repo/semantics/article
publication-article
oai:aperta.ulakbim.gov.tr:237032
2022-10-07T09:48:32Z
user-tubitak-destekli-proje-yayinlari
Colak, Hakan
Karakose, Ercan
2022-01-01
This study reports the production of Gd(III)-doped ZnO nanorods on the glass substrate via spin coating and hydrothermal routes, respectively, and investigation of CO2 gas sensing properties. It was determined that the response of the ZnO nanorods to CO2 gas under the open-air atmosphere increases with doping concentration (up to 3 mol %) and temperature. The optimum operating temperature of the sensors was determined as 200 degrees C, and the response of the 3 mol % doped sample was about 85% at this temperature. The response and recovery times to 100 ppm concentration of CO2 gas were determined as 30 and 25 s, respectively. The 3 mol % Gd(III)-doped ZnO nanorods sensor has quite high sensitivities for CO2 gas compared to acetone and ethanol. In addition, it was observed that the 3 mol % Gd(III)-doped ZnO nanorod sensor maintained its response stability against CO2, acetone, and ethanol gases for 30 days.
https://aperta.ulakbim.gov.trrecord/237032
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MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING 139
Gadolinium(III)-doped ZnO nanorods and gas sensing properties
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publication-article
oai:aperta.ulakbim.gov.tr:231332
2022-10-07T08:06:14Z
user-tubitak-destekli-proje-yayinlari
Cayan, Fatih
Tel-Cayan, Gulsen
Deveci, Ebru
Duru, Mehmet Emin
Turk, Mustafa
2022-01-01
Mushrooms and truffles are attracting attention as a new generation of biotherapeutics. In the current study, isolation, phenolic and organic acid composition, and antioxidant, cytotoxic, anticholinesterase activities of truffle Reddellomyces parvulosporus were examined. Four known compounds (brassicasterol (1), ergosterol peroxide (2), fumaric acid (3) and mannitol (4)) were isolated with the combination of chromatographic techniques. Fumaric acid (54.74 +/- 0.85 mu g g(-1)) was found as the major compound by HPLC-DAD. All isolated compounds were bioassayed for antioxidant, cytotoxic, anticholinesterase, anti-tyrosinase, anti-urease, anti-alpha-glucosidase and anti-alpha-amylase activities. Compound 1 indicated notable cytotoxic activity on MCF-7 (IC50: 38.08 +/- 0.75 mu g mL(-1)) and compound 3 on H1299 (IC50: 62.37 +/- 0.75 mu g mL(-1)). Also, compounds 1 (84.55 +/- 1.14%) and 2 (84.90 +/- 0.10%) showed higher anti-urease activity than thiourea (78.57 +/- 0.22%), while compound 2 (66.31 +/- 0.08%) displayed near-standard anti-BChE activity. Also, being the first to emphasise the potential of R. parvulosporus as a natural food additive, this study evidenced its medicinal importance by revealing bioactive compounds and properties.
https://aperta.ulakbim.gov.trrecord/231332
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INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY 57(3) 1411-1419
A detailed study on multifaceted bioactivities of the extracts and isolated compounds from truffle Reddellomyces parvulosporus
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publication-article
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